{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:39:35Z","timestamp":1777876775625,"version":"3.51.4"},"reference-count":64,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Med Oncol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Medulloblastoma (MB) relapse is typically resistant to available treatments. An emerging alternative strategy focuses on disrupting tumor angiogenesis at various stages, using a combined metronomic anti-angiogenic approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The study aims to assess the efficacy and safety of this modified treatment approach in managing recurrent MB in the pediatric population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Designs:<\/jats:title>\n                    <jats:p>This study is a retrospective observational analysis involving 14 pediatric patients diagnosed with first or multiple recurrences of MB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We analyzed clinical, molecular, radiological, and outcome data of our cohort treated using a modified Medulloblastoma European Multitarget Metronomic Anti-Angiogenic Trial (MEMMAT) strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Median age of patients was 11.6\u2009years (range: 6.4\u201326\u2009years). All 14 patients presented with a metastatic relapse after conventional treatments. The median time from primary diagnosis\/prior relapse to the start of \u201cmodified MEMMAT\u201d was 22\u2009months (range: 2\u201360\u2009months). Fifty-seven percent received the \u201cmodified MEMMAT\u201d schema as second-line treatment, while 43% received it as third-line or beyond after recurrence. At a median follow-up of 17.9\u2009months, the median overall survival (OS) from the MEMMAT start date was 18.2\u2009months, and the median progression-free survival (PFS) was 12.8\u2009months. OS at 12 and 24\u2009months was 78.6% and 28.6%, respectively. PFS at 6 and 12\u2009months was 100% and 55.0%, respectively. Treatment was globally well tolerated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The modified MEMMAT strategy shows promise in treating recurrent MB, achieving a 12-month OS rate from date of starting treatment of 78.6%, with manageable toxicity. These findings suggest its potential as a viable option for heavily pre-treated pediatric patients, warranting further validation in larger prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17588359251344002","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:09:42Z","timestamp":1758359382000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Real-life experience with a \u201cmodified-MEMMAT\u201d regimen for relapsed medulloblastoma"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4901-9952","authenticated-orcid":false,"given":"Antonella","family":"Cacchione","sequence":"first","affiliation":[{"name":"Department of Pediatric Haematology and Oncology, and Cell and Gene Therapy, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3540-4331","authenticated-orcid":false,"given":"Giada","family":"Del Baldo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Haematology and Oncology, and Cell and Gene Therapy, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"},{"name":"Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"D\u2019Antonio","sequence":"additional","affiliation":[{"name":"Department of Pediatric Haematology and Oncology, and Cell and Gene Therapy, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"},{"name":"Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Di Ruscio","sequence":"additional","affiliation":[{"name":"Department of Pediatric Haematology and Oncology, and Cell and Gene Therapy, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomina","family":"Megaro","sequence":"additional","affiliation":[{"name":"Department of Pediatric Haematology and Oncology, and Cell and Gene Therapy, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Pilotto","sequence":"additional","affiliation":[{"name":"Pediatric Clinic, ASUFC Santa Maria Della Misericordia, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assunta","family":"Tornesello","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Unit, Ospedale Vito Fazzi, Lecce, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Cocciolo","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Unit, Ospedale Vito Fazzi, Lecce, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Vennarini","sequence":"additional","affiliation":[{"name":"Pediatric Radiotherapy Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Chiesa","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Fondazione Policlinico Universitario \u201cA. Gemelli,\u201d Catholic University of Sacred Heart, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5203-7855","authenticated-orcid":false,"given":"Andrea","family":"Carai","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, Department of Neurosciences, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"De Salvo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Haematology and Oncology, and Cell and Gene Therapy, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6266-0966","authenticated-orcid":false,"given":"Giulia","family":"Albino","sequence":"additional","affiliation":[{"name":"Department of Pediatric Haematology and Oncology, and Cell and Gene Therapy, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna Stefania","family":"Colafati","sequence":"additional","affiliation":[{"name":"Imaging Department, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Slavc","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Mastronuzzi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Haematology and Oncology, and Cell and Gene Therapy, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, Piazza Sant\u2019Onofrio, Rome 00165, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,20]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nou327"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noac161"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2018.04.009"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.4324"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.5148"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.4974"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003088"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0922-z"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30243-7"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-019-02020-0"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/now076.104"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.9984"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14020374"},{"issue":"1","key":"e_1_3_4_16_2","article-title":"Effective re-induction regimen for children with recurrent medulloblastoma","volume":"6","author":"O\u2019Halloran K","year":"2024","unstructured":"O\u2019Halloran K, Phadnis S, Friedman GK, et al. 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