{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:46:16Z","timestamp":1789670776312,"version":"4.0.1"},"reference-count":52,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2019\/35\/O\/NZ2\/03761"],"award-info":[{"award-number":["2019\/35\/O\/NZ2\/03761"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Med Oncol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    Soft tissue sarcomas (STS) are rare mesenchymal tumors in which gene fusions occur in approximately one-third of cases, serving as key diagnostic and therapeutic targets. This study investigates the presence and implications of gene fusions in STS, focusing on a novel\n                    <jats:italic toggle=\"yes\">PRUNE2::NTRK2<\/jats:italic>\n                    gene fusion identified in two adult patients. The\n                    <jats:italic toggle=\"yes\">PRUNE2<\/jats:italic>\n                    gene plays a role in cellular processes and is a potential tumor biomarker. PRUNE2 plays a role in various tumors as a tumor suppressor, including prostate cancer, colorectal cancer, and neuroblastoma. The\n                    <jats:italic toggle=\"yes\">NTRK2<\/jats:italic>\n                    oncogene is, however, associated with tumor progression. In this report, we describe a possible molecular characterization of a novel\n                    <jats:italic toggle=\"yes\">PRUNE2::NTRK2<\/jats:italic>\n                    gene fusion. Although\n                    <jats:italic toggle=\"yes\">NTRK<\/jats:italic>\n                    -associated fusions are significant in various cancers and have led to the development of targeted therapies, such as larotrectinib and entrectinib, the specific molecular impact of atypical\n                    <jats:italic toggle=\"yes\">PRUNE2::NTRK2<\/jats:italic>\n                    fusion remains unclear. The\n                    <jats:italic toggle=\"yes\">PRUNE2::NTRK2<\/jats:italic>\n                    gene fusions described here express a non-functional TrkB protein, and it is unclear whether the PRUNE2 function is intact or affected.\n                  <\/jats:p>","DOI":"10.1177\/17588359251395379","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T06:16:32Z","timestamp":1764310592000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Identification of a novel\n                    <i>PRUNE2::NTRK2<\/i>\n                    gene fusion in soft tissue sarcoma patients\u2014friend or foe? Case series"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7786-9132","authenticated-orcid":false,"given":"Klaudia","family":"Bobak","sequence":"first","affiliation":[{"name":"Department of Soft Tissue\/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, W. K. Roentgena 5, Warsaw 02-781, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Tysarowski","sequence":"additional","affiliation":[{"name":"Cancer Molecular and Genetic Diagnostics Laboratory, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna A.","family":"Seliga","sequence":"additional","affiliation":[{"name":"Cancer Molecular and Genetic Diagnostics Laboratory, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Pia\u0327tkowski","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Institute of Genetics and Biotechnology, University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7814-482X","authenticated-orcid":false,"given":"Pawe\u0142","family":"Golik","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Institute of Genetics and Biotechnology, University of Warsaw, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz J.","family":"Spa\u0142ek","sequence":"additional","affiliation":[{"name":"Department of Soft Tissue\/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland"},{"name":"Department of Radiotherapy I, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Szumera-Cie\u0107kiewicz","sequence":"additional","affiliation":[{"name":"Department of Cancer Pathomorphology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland"},{"name":"Diagnostic Hematology Department, Institute of Hematology and Transfusion Medicine, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Rutkowski","sequence":"additional","affiliation":[{"name":"Department of Soft Tissue\/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Czarnecka","sequence":"additional","affiliation":[{"name":"Department of Soft Tissue\/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland"},{"name":"Department of Experimental Pharmacology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/ortho.IJOrtho_220_17"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22335"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-022-02106-2"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-29511-1"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001447"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom14101297"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05211-w"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1214262"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15317"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-00719-0"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2021.03.012"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2020.11.010"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-022-02533-1"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.014328"},{"key":"e_1_3_4_16_2","article-title":"NTRK fusions in sarcomas: diagnostic challenges and clinical aspects","volume":"11","author":"Siozopoulou V","year":"2021","unstructured":"Siozopoulou V, Smits E, De Winne K, et al. 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