{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T02:37:52Z","timestamp":1793587072963,"version":"4.5.0"},"reference-count":47,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Med Oncol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Metastatic urothelial carcinoma (mUC) remains a challenging malignancy with limited treatment options. The combination of RC48 (Disitamab Vedotin) plus programmed cell death protein 1 (PD-1) inhibitor represents a promising therapeutic strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of RC48 plus PD-1 inhibitors as first-line therapy for mUC in real-world practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A multicenter, retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively collected data from mUC patients who received RC48 plus PD-1 inhibitors as first-line therapy between July 2021 and February 2024 from three medical centers. Overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and disease control rate (DCR) were calculated to evaluate the clinical efficacy. Treatment-related adverse events (TRAEs) were analyzed to assess the safety profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 63 patients with mUC were included, with a mean age of 67\u2009years, and 71.4% were male. The most frequent metastatic sites were lymph nodes (77.8%), followed by the lung (31.7%), bone (23.8%), liver (19.0%), and others. The treatment response rates were as follows: 12 patients (19.0%) achieved a complete response, 33 patients (52.4%) had a partial response, and 10 patients (15.9%) experienced stable disease. The ORR was 71.4%, and the DCR was 87.3%. The median PFS was 10.5\u2009months (95% confidence interval: 8.8\u201314.6\u2009months), and the median OS was not reached. The most common TRAEs included fatigue (36.5%), anemia (34.9%), pruritus (33.3%), peripheral sensory neuropathy (28.6%), and nausea (28.6%). Grade III TRAEs occurred in seven patients (11.1%), and no Grade IV or V TRAEs were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The combination of RC48 and PD-1 inhibitors administered in 3-week cycles demonstrates efficacy and manageable safety as first-line therapy for mUC patients in a real-world setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17588359251395928","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T04:28:24Z","timestamp":1764476904000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and safety of a novel treatment scheme of RC48-ADC plus PD-1 inhibitors in metastatic urothelial carcinoma: a multicenter real-world study"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1666-7530","authenticated-orcid":false,"given":"Jun","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Urology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China"},{"name":"Graduate of School, Fujian Medical University, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7970-6257","authenticated-orcid":false,"given":"Junjie","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Urology, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoan","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Urology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Urology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China"},{"name":"Graduate of School, Fujian Medical University, Fuzhou, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second Affiliated Hospital of Fujian University of Traditional Chinese 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