{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:34:22Z","timestamp":1788975262821,"version":"build-2803163510"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Science and Technology Development Fund of Shanghai Pudong New Area","award":["PKJ2021-Y45"],"award-info":[{"award-number":["PKJ2021-Y45"]}]},{"DOI":"10.13039\/501100001809","name":"national natural science foundation of china","doi-asserted-by":"publisher","award":["82103059"],"award-info":[{"award-number":["82103059"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the National Natural Science Foundation of Yunnan Province","award":["202305AS350028"],"award-info":[{"award-number":["202305AS350028"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Med Oncol"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The optimal treatment approach for lacrimal gland adenoid cystic carcinoma (LGACC) remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We aim to demonstrate the value of radiotherapy (RT) in the multidisciplinary treatment of LGACC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This was a retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study was conducted on 90 patients with LGACC treated from 2002 to 2023. We compared the overall survival (OS), progression-free survival (PFS), recurrence-free survival (RFS), and distant metastasis-free survival (DMFS) between those treated with surgery alone versus surgery plus postoperative radiotherapy (PORT). In addition, the ipsilateral visual outcome and ocular complications were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The addition of radiotherapy significantly improved the 5-year RFS (63.4% vs 31.1%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.014) and PFS (56.8% vs 31.1%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.036) while showing no improvement in OS (79.7% vs 85.6%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.98) and DMFS (67.3% vs 70.1%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.70) compared to surgery alone. Further analysis indicated that, compared to the photon-RT group, the proton\/carbon-ion group showed no significant differences in 5-year OS (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.7), RFS (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.37), PFS (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.45), and DMFS (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.57). Univariate (odds ratio (OR)\u2009=\u20090.14, 95% confidence interval (CI): 0.04\u20130.49,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.002) and multivariate (OR\u2009=\u20090.16, 95% CI: 0.04\u20130.62,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.008) logistic regression indicated that radiotherapy was a protective factor for local recurrence. Furthermore, among the long follow-up of 35 patients accepting eye-sparing surgery plus PORT, 13 patients (37.1%) had best-corrected visual acuity (\u2a7e20\/40) and 14 (40.0%) had severe vision loss (&lt;20\/200); furthermore, dry eye disease (100%, 35\/35) and cataract progression (45.7%,16\/35) are the most common ocular complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Surgery plus radiotherapy is a safe and effective multidisciplinary treatment in improving local control with tolerable long-term ocular toxicity, but of limited impact on OS for LGACC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17588359251413440","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:51:44Z","timestamp":1769165504000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of radiotherapy in the multidisciplinary treatment of lacrimal gland adenoid cystic carcinoma"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6358-597X","authenticated-orcid":false,"given":"Li","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Eye &amp; ENT Hospital of Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuqian","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye &amp; ENT Hospital of Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology, 920th Hospital of Joint Logistics Support Force, Kunming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye &amp; ENT Hospital of Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1861-6252","authenticated-orcid":false,"given":"Tian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Eye &amp; ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmao","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Eye &amp; ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000000531"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-021-00857-1"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.IOP.0000105518.72611.4F"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-023-04426-5"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000301"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24433"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000000877"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2024.01.22"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24044"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2021.04.11"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.07.024"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24390"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e318295f99b"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27223"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.01.027"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2022.03.027"},{"key":"e_1_3_4_19_2","article-title":"Current trends in the management of epithelial lacrimal gland tumors: a retrospective national cancer database analysis","volume":"14","author":"Ashok Kumar P","year":"2022","unstructured":"Ashok Kumar P, Wang D, Huang D, et al. 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