{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T13:00:30Z","timestamp":1780750830412,"version":"3.54.1"},"reference-count":47,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Med Oncol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Reintroduction of oxaliplatin after first-line treatment might preserve treatment lines and could improve overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We investigate whether oxaliplatin reintroduction (OXR) or paclitaxel-ramucirumab (PR) is preferred in terms of overall survival for patients with gastroesophageal adenocarcinoma who have disease progression on first-line treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>We performed a target trial emulation with a propensity-scored inverse probability weighting approach to resemble a randomized controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Observational data was retrieved from the Netherlands Cancer Registry between 2015 and 2018, with a maximum follow-up until 2022. Patients were included if they received a fluoropyrimidine with oxaliplatin in first-line and as subsequent treatment OXR or PR. There was at least 6\u2009months between planned discontinuation of oxaliplatin and disease progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We included 129 patients in our model and the weighted cohort was well balanced between the two groups. No statistically significant difference in overall survival was observed between treatment groups (HR: 0.76, 95% CI: 0.3\u20131.5;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.36). Median overall survival was 9.2\u2009months (95% CI: 3.7\u201325.1) for OXR and 7.9\u2009months (95% CI: 2.8\u201311.5) for PR (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.38). Exploratory subgroup analysis did not reach statistical significance. Patients in the OXR-group more often received one or more additional treatment lines, including second-line PR, than patients in the PR group, 47.7% versus 23.3%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>OXR following prolonged response to first-line treatment was associated with similar overall survival compared with PR. In the absence of a demonstrated survival benefit for either treatment, these results propose oxaliplatin reintroduction as a potential option in selected patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17588359261442616","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:03:43Z","timestamp":1780484623000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Second-line oxaliplatin reintroduction or paclitaxel-ramucirumab in metastatic gastroesophageal cancer: a population-based study"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3692-844X","authenticated-orcid":false,"given":"Sebastiaan N.","family":"Siegerink","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Amsterdam UMC, Office 8D-XXX, PO Box 22660, Amsterdam 1100DD, The Netherlands"},{"name":"Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Kuijper","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands"},{"name":"Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2830-2310","authenticated-orcid":false,"given":"Tom","family":"van den Ende","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands"},{"name":"Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9678-1611","authenticated-orcid":false,"given":"Rob H. A.","family":"Verhoeven","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands"},{"name":"Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, The Netherlands"},{"name":"Department of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd G.","family":"Elias","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia Haj","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4181-8656","authenticated-orcid":false,"given":"Marije","family":"Slingerland","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Derks","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands"},{"name":"Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, The Netherlands"},{"name":"Oncode Institute, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1274-5643","authenticated-orcid":false,"given":"Hanneke W. 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