{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T07:42:00Z","timestamp":1786261320496,"version":"build-2736575974"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","award":["2023-I2M-3-012"],"award-info":[{"award-number":["2023-I2M-3-012"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2025-PUMCH-D-001"],"award-info":[{"award-number":["2025-PUMCH-D-001"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Med Oncol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinicians often screen for autoantibodies before initiating immune checkpoint inhibitors (ICIs) in advanced gastric cancer (GC), yet the utility of organ-specific panels remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the association of baseline antinuclear antibody (ANA) titers and organ-specific autoantibodies with severe immune-related adverse events (irAEs) and clinical outcomes in patients with advanced GC receiving ICIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Single-center retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 244 patients with advanced GC treated with ICIs. Baseline ANA titers and organ-specific antibodies, including Ro52, thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb), were systematically evaluated. Associations with grade 3\u20134 irAEs were assessed using Firth\u2019s penalized logistic regression. Progression-free survival (PFS) was analyzed using Kaplan\u2013Meier methods, Cox proportional hazards regression, subgroup analyses, and propensity score matching.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of organ-specific antibodies was low (&lt;7%) and failed to predict toxicity. In contrast, high-titer ANA (\u22651:160, 17.6% of patients) predicted grade 3\u20134 irAEs (OR = 7.98, 95% CI: 3.35\u201319.5; p &lt; 0.001). Although the high-titer ANA group included a numerically higher proportion of PD-L1-negative tumors, exploratory survival analyses showed longer PFS in patients with high-titer ANA in univariable analysis (p = 0.038), whereas the association was attenuated after multivariable adjustment (adjusted HR = 0.60, 95% CI: 0.35\u20131.01, p = 0.056) and remained borderline after propensity score matching (p = 0.049).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High-titer ANA was associated with an increased risk of severe irAEs in patients with advanced GC receiving ICIs. Its association with longer PFS was exploratory and requires prospective validation. These findings suggest that ANA titers may help baseline toxicity risk stratification, whereas routine screening for low-yield organ-specific autoantibodies may offer limited clinical utility in unselected patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17588359261476860","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T19:51:17Z","timestamp":1786045877000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["High-titer antinuclear antibodies are associated with severe immune-related toxicity and exploratory survival outcomes in advanced gastric cancer immunotherapy"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3026-4009","authenticated-orcid":false,"given":"Wanrong","family":"Liu","sequence":"first","affiliation":[{"name":"Peking Union Medical College Hospital"},{"name":"Chinese Academy of Medical Sciences & 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