{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T08:26:08Z","timestamp":1787214368648,"version":"build-2736575974"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"NCCS Cancer fund"},{"DOI":"10.13039\/100018059","name":"Tanoto Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100018059","id-type":"DOI","asserted-by":"crossref"}]},{"name":"SingHealth Duke-NUS AM\/ACP-Designated Philanthropic Fund Grant Award","award":["08\/FY2023\/EX\/27-A65"],"award-info":[{"award-number":["08\/FY2023\/EX\/27-A65"]}]},{"name":"Khoo Bridge Funding Award provided by Duke-NUS Medical School and the \u201cEstate of Tan Sri Khoo Teck Puat\u201d","award":["Duke-NUS-KBrFA\/2025\/0090"],"award-info":[{"award-number":["Duke-NUS-KBrFA\/2025\/0090"]}]},{"name":"Singapore Ministry of Health\u2019s National Medical Research Council","award":["Research Transition Award (TA21jun-0005), Clinician Scientist Individual Research Grant (CIRG25jan-0007), Large Collaborative Grant (OFLCG23May-0039), TETRAD II Collaborative Centre Grant (CG21APR2002)"],"award-info":[{"award-number":["Research Transition Award (TA21jun-0005), Clinician Scientist Individual Research Grant (CIRG25jan-0007), Large Collaborative Grant (OFLCG23May-0039), TETRAD II Collaborative Centre Grant (CG21APR2002)"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Med Oncol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Solitary fibrous tumors (SFTs) are rare fibroblastic neoplasms for which prognostication is challenging. Peripheral hematological indices such as lymphocyte-monocyte ratio (LMR) and neutrophil-lymphocyte ratio (NLR) have demonstrated prognostic value in various malignancies but remain incompletely characterized in localized SFTs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to investigate clinicopathological factors and peripheral blood counts as predictors of survival outcomes in patients with SFT; and to explore their relationship with intratumoral gene expression profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed patients with localized SFT managed at the National Cancer Centre Singapore (n = 77). Cut-offs for indices were derived from prior studies, and survival outcomes were analyzed using the Kaplan-Meier method and Cox proportional-hazards regression. Subgroup analysis with the NanoString PanCancer IO360 panel (n = 9) was done to explore associations between peripheral LMR and intratumoral immune-oncologic signals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median age at diagnosis was 55.7 years (range: 12.7 to 86.5 years) with a median follow-up time of 10.1 years. Low LMR (\u2264 2.4) was observed in 14 patients (18.2%) and was significantly associated with poorer overall survival (OS) (HR 6.73, 95% CI 1.65 \u2013 27.4,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0078) alongside older age (&gt; 65 years) and absence of curative surgery. Low LMR was also associated with poorer metastatic-free survival (MFS) (HR 5.11, 95% CI 1.48 \u2013 17.70,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0101) and trended toward worse event-free survival (EFS) (HR 2.76, 95% CI 0.92 \u2013 8.31,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.071). LMR-low was significantly correlated with lower lymphocyte counts (median: 1.23 vs 1.94\u00d710\n                      <jats:sup>9<\/jats:sup>\n                      \/L;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001) and higher monocyte counts (median: 0.66 vs 0.51\u00d710\n                      <jats:sup>9<\/jats:sup>\n                      \/L;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0041). Using NanoString analysis, LMR was negatively correlated with intratumoral cytokine and chemokine signaling pathway scores (rho = -0.733,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0246), mast cell scores (rho = -0.700,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0358) and CD8 T cells (rho = -0.667,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0499).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LMR may hold prognostic value for SFTs, though further validation in larger, multi-institutional cohorts is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17588359261480333","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:37:48Z","timestamp":1787045868000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and hematological indices as prognosticators in localized solitary fibrous tumors: A retrospective study"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6429-3919","authenticated-orcid":false,"given":"Ariel Yoong Yi","family":"KOH","sequence":"first","affiliation":[{"name":"Duke-NUS Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan Mao Heng","family":"LIM","sequence":"additional","affiliation":[{"name":"National Cancer Centre Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4801-3703","authenticated-orcid":false,"given":"Jason Yongsheng","family":"CHAN","sequence":"additional","affiliation":[{"name":"Duke-NUS Medical School"},{"name":"National Cancer Centre Singapore"},{"name":"National Cancer Centre Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001552"},{"key":"e_1_3_7_3_2","author":"WHO. 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