{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:27:56Z","timestamp":1785529676384,"version":"3.56.0"},"reference-count":35,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["ASN Neuro"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1177\/1759091420918557","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:58:27Z","timestamp":1586912307000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":9,"title":["Alzheimer Drug Trials: Combination of Safe and Efficacious Biologicals to Break the Amyloidosis-Neuroinflammation Vicious Cycle"],"prefix":"10.1080","volume":"12","author":[{"given":"Tamas","family":"Bartfai","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden"},{"name":"Department of Pharmacology (adjunct), University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1856-8732","authenticated-orcid":false,"given":"Graham V.","family":"Lees","sequence":"additional","affiliation":[{"name":"Corpus Alienum Oy, Kirkkonummi, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,4,14]]},"reference":[{"key":"e_1_3_4_2_1","volume-title":"Drug discovery: From bedside to Wall Street","author":"Bartfai T.","year":"2006","unstructured":"Bartfai, T., Lees, G. V. (2006). Drug discovery: From bedside to Wall Street.Elsevier Academic Press."},{"key":"e_1_3_4_3_1","volume-title":"The future of drug discovery: Who decides which diseases to treat","author":"Bartfai T.","year":"2013","unstructured":"Bartfai, T., Lees, G. V. (2013). The future of drug discovery: Who decides which diseases to treat.Academic Press."},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0057-5"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2013.833510"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706314"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12317"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20030558"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1312889"},{"key":"e_1_3_4_10_1","unstructured":"Fagan T. (2019). Biogen\/Eisai halt Phase 3 aducanumab trials. Alzforum. https:\/\/www.alzforum.org\/news\/research-news\/biogeneisai-halt-phase-3-aducanumab-trials"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.11140.1"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1636"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0079-7"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201709069"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0055-7"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.1.JNS172938"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000266"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24806"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710311114"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14945"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(01)00287-1"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006338"},{"key":"e_1_3_4_24_1","unstructured":"Netzer W. J. (2015). Experimental Alzheimer\u2019s drug aducanumab slows cognitive decline in early trials. Alzinfo. https:\/\/www.alzinfo.org\/articles\/diagnosis\/experimental-alzheimers-drug-aducanumab-slows-cognitive-decline-in-early-trials\/"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0602-2"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S53401"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2017.03.011"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2772-2"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70043-0"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30480-6"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1228541"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0205-1"},{"key":"e_1_3_4_33_1","unstructured":"Selkoe D. J. (2019b October). Biogen\u2019s good news on aducanumab could \u2018open the floodgates\u2019 for Alzheimer\u2019s drugs. STAT."},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19323"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(96)00104-2"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25158"}],"container-title":["ASN Neuro"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1759091420918557","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1759091420918557","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1177\/1759091420918557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T15:30:53Z","timestamp":1736523053000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1177\/1759091420918557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1177\/1759091420918557"],"URL":"https:\/\/doi.org\/10.1177\/1759091420918557","relation":{},"ISSN":["1759-0914"],"issn-type":[{"value":"1759-0914","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tasn20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=tasn20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-19","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1759091420918557"}}