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Important discoveries over the past 10\u201315 years have led to more targeted treatments for children with JIA. The International League of Associations for Rheumatology (ILAR) classification system for childhood arthritides, better assessment tools for clinical response, improved definitions of remission, new imaging techniques and evidence in gene expression profiling have all contributed to the development of more targeted treatments. Nonsteroidal anti-inflammatory agents still have a role in mild disease and intra-articular steroid injections continue to be used most commonly in patients with oligoarticular JIA. Disease-modifying agents such as methotrexate have demonstrated efficacy and safety; however, in many patients, the disease remains active despite this treatment. These children now receive more targeted treatment including the tumor necrosis factor alpha (TNF\u03b1) inhibitors, interleukin-1 blockade, interleukin-6 blockade, selective costimulation modulators and selective B-cell blockade. The biologic targeted therapies have changed the strategy in which we treat our children with JIA; however, there remains much to be learned about the long-term effects and safety of these medicines.<\/jats:p>","DOI":"10.1177\/1759720x11413630","type":"journal-article","created":{"date-parts":[[2011,8,22]],"date-time":"2011-08-22T23:32:54Z","timestamp":1314055974000},"page":"99-110","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Juvenile idiopathic arthritis: management and therapeutic options"],"prefix":"10.1177","volume":"4","author":[{"given":"Natasha M.","family":"Ruth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray H.","family":"Passo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,8,22]]},"reference":[{"key":"bibr1-1759720X11413630","doi-asserted-by":"publisher","DOI":"10.1002\/art.24087"},{"key":"bibr2-1759720X11413630","doi-asserted-by":"publisher","DOI":"10.1002\/art.24601"},{"key":"bibr3-1759720X11413630","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.1.6.9884"},{"key":"bibr4-1759720X11413630","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100711"},{"key":"bibr5-1759720X11413630","doi-asserted-by":"publisher","DOI":"10.1002\/art.24190"},{"key":"bibr6-1759720X11413630","first-page":"1918","volume":"34","author":"Beukelman T.","year":"2007","journal-title":"J Rheumatol"},{"key":"bibr7-1759720X11413630","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20460"},{"key":"bibr8-1759720X11413630","first-page":"724","volume":"70","author":"Bhettay E.","year":"1986","journal-title":"Suid-Afrikaanse tydskrif vir geneeskunde"},{"key":"bibr9-1759720X11413630","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-010-1238-z"},{"key":"bibr10-1759720X11413630","first-page":"2696","volume":"27","author":"Breit W.","year":"2000","journal-title":"J Rheumatol"},{"key":"bibr11-1759720X11413630","unstructured":"Center for Drug Evaluation and Research (1999) Guidance for Industry: clinical development programs for drugs, devices, and biological products for the treatment of rheumatoid arthritis. 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