{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:41:43Z","timestamp":1777876903082,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2016,7,31]],"date-time":"2016-07-31T00:00:00Z","timestamp":1469923200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>We evaluated agreement among several definitions of accelerated knee osteoarthritis (AKOA) and construct validity by comparing their individual associations with injury, age, obesity, and knee pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We selected knees from the Osteoarthritis Initiative that had no radiographic knee osteoarthritis [Kellgren\u2013Lawrence (KL) 0 or 1] at baseline and had high-quality quantitative medial joint space width (JSW) measures on two or more consecutive visits ( n = 1655 knees, 1143 participants). Quantitative medial JSW was based on a semi-automated method and was location specific ( x = 0.25). We compared six definitions of AKOA: stringent JSW (averaged): average JSW loss greater than 1.05 mm\/year over 4 years; stringent JSW (consistent): JSW loss greater than 1.05 mm\/year for at least 2 years; lenient JSW (averaged): average JSW loss greater than 0.25 mm\/year over 4 years; lenient JSW (consistent): JSW loss greater than 0.25 mm\/year for at least 2 years; comprehensive KL based: progression from no radiographic osteoarthritis to advance-stage osteoarthritis (KL 3 or 4; development of definite osteophyte and joint space narrowing) within 4 years; and lenient KL based: an increase of at least two KL grades within 4 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Over 4 years the incidence rate of AKOA was 0.4%, 0.8%, 15.5%, 22.1%, 12.4%, and 7.2% based on the stringent JSW (averaged and consistent), lenient JSW (averaged and consistent), lenient KL-based definition, and comprehensive KL-based definition. All but one knee that met the stringent JSW definition also met the comprehensive KL-based definition. There was fair substantial agreement between the lenient JSW (averaged), lenient KL-based, and comprehensive KL-based definitions. A comprehensive KL-based definition led to larger effect sizes for injury, age, body mass index, and average pain over 4 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>A comprehensive KL-based definition of AKOA may be ideal because it represents a broader definition of joint deterioration compared with those focused on just joint space or osteophytes alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x16658032","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T20:39:19Z","timestamp":1467923959000},"page":"165-171","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Best performing definition of accelerated knee osteoarthritis: data from the Osteoarthritis Initiative"],"prefix":"10.1177","volume":"8","author":[{"given":"Jeffrey B.","family":"Driban","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Tufts Medical Center, 800 Washington Street, Box 406, Boston, MA 02111, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina C.","family":"Stout","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Tufts Medical Center, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace H.","family":"Lo","sequence":"additional","affiliation":[{"name":"Medical Care Line and Research Care Line, Houston Health Services Research and Development (HSR&D) Center of Excellence Michael E. DeBakey VAMC, Houston, TX, USA"},{"name":"Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles B.","family":"Eaton","sequence":"additional","affiliation":[{"name":"Center for Primary Care and Prevention, Alpert Medical School of Brown University, Pawtucket, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori Lyn","family":"Price","sequence":"additional","affiliation":[{"name":"The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA"},{"name":"Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Lu","sequence":"additional","affiliation":[{"name":"Brigham & Women\u2019s Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary F.","family":"Barbe","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy E.","family":"McAlindon","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Tufts Medical Center, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,31]]},"reference":[{"key":"bibr1-1759720X16658032","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20614"},{"key":"bibr2-1759720X16658032","doi-asserted-by":"publisher","DOI":"10.1186\/ar2774"},{"key":"bibr3-1759720X16658032","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-3152-2"},{"key":"bibr4-1759720X16658032","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22359"},{"key":"bibr5-1759720X16658032","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-3128-2"},{"key":"bibr6-1759720X16658032","doi-asserted-by":"publisher","DOI":"10.1002\/ca.22590"},{"key":"bibr7-1759720X16658032","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2002.0866"},{"key":"bibr8-1759720X16658032","doi-asserted-by":"publisher","DOI":"10.1002\/art.24791"},{"key":"bibr9-1759720X16658032","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.10.005"},{"key":"bibr10-1759720X16658032","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"bibr11-1759720X16658032","doi-asserted-by":"publisher","DOI":"10.1136\/ard.57.10.595"},{"key":"bibr12-1759720X16658032","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2003.09.004"},{"key":"bibr13-1759720X16658032","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.02.281"},{"key":"bibr14-1759720X16658032","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.11.001"},{"key":"bibr15-1759720X16658032","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.09.015"},{"key":"bibr16-1759720X16658032","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.11.790"},{"key":"bibr17-1759720X16658032","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203829"}],"container-title":["Therapeutic Advances in Musculoskeletal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1759720X16658032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1759720X16658032","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1759720X16658032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:35:51Z","timestamp":1777588551000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1759720X16658032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,31]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1177\/1759720X16658032"],"URL":"https:\/\/doi.org\/10.1177\/1759720x16658032","relation":{},"ISSN":["1759-720X","1759-7218"],"issn-type":[{"value":"1759-720X","type":"print"},{"value":"1759-7218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,31]]}}}