{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:29:59Z","timestamp":1790972999041,"version":"4.1.0"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>\n                    Periodontitis is an inflammatory disease of dental supporting tissues (gingiva, periodontal ligament, and bone) and it has been suggested as a possible etiology for rheumatoid arthritis (RA). In this systematic review, we aim to verify if periodontitis represents a risk factor for RA. Electronic databases were consulted until March 2018 considering eligibility criteria focusing on: (P, participants) adults; (E, exposure) with periodontitis; (C, comparison) without periodontitis; and (O, outcome) development of RA. Quality assessment of studies and risk-of-bias evaluation were also performed. To undertake a quantitative analysis, the number of persons with RA and a total number of participants for the case group (with periodontitis) and control group (without periodontitis) were used to calculate the odds ratio (OR) with a 95% confidence interval (CI). A total of 3888 articles were identified, and nine studies were considered eligible. Seven of 9 articles suggested an association among diseases by the common pro-inflammatory profiles. The pooled analysis of 3 articles showed a higher RA prevalence for persons with periodontitis ( n\u2009=\u20091177) than controls ( n\u2009=\u2009254) (OR 1.97; CI 1.68\u20132.31; p\u2009&lt;\u20090.00001). However, considerable heterogeneity among studies was verified (I\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200996%, p\u2009&lt;\u20090.00001). Periodontitis may represent a risk factor for RA by heredity, bacterial infection, and the pro-inflammatory profile shared between both diseases. Although most of the elective studies report an association between periodontitis and RA, the quantitative analysis showed a high heterogeneity, leading to the need for further studies.\n                  <\/jats:p>","DOI":"10.1177\/1759720x19858514","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T02:45:06Z","timestamp":1562726706000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":47,"title":["Does periodontitis represent a risk factor for rheumatoid arthritis? A systematic review and meta-analysis"],"prefix":"10.1177","volume":"11","author":[{"given":"Railson","family":"de Oliveira Ferreira","sequence":"first","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Universidade Federal do Par\u00e1, Bel\u00e9m, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00edra","family":"de Brito Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Universidade Federal do Par\u00e1, Bel\u00e9m, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela Bara\u00fana","family":"Magno","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry and Orthodontics, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Paula Costa Ponte Sousa","family":"Carvalho Almeida","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Universidade Federal do Par\u00e1, Bel\u00e9m, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nath\u00e1lia Carolina Fernandes","family":"Fagundes","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Universidade Federal do Par\u00e1, Bel\u00e9m, Brazil"},{"name":"Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucianne Cople","family":"Maia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry and Orthodontics, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1486-4013","authenticated-orcid":false,"given":"Rafael Rodrigues","family":"Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Par\u00e1, Rua Augusto Corr\u00eaa 1, Guam\u00e1, Bel\u00e9m, PA 66075-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,7,9]]},"reference":[{"key":"bibr1-1759720X19858514","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.8.1406"},{"key":"bibr2-1759720X19858514","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186346"},{"key":"bibr3-1759720X19858514","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906-6713.2002.003421.x"},{"key":"bibr4-1759720X19858514","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.157001"},{"key":"bibr5-1759720X19858514","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12222"},{"key":"bibr6-1759720X19858514","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2016.866"},{"key":"bibr7-1759720X19858514","doi-asserted-by":"publisher","DOI":"10.1186\/ar2669"},{"key":"bibr8-1759720X19858514","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaj1921"},{"key":"bibr9-1759720X19858514","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513483142"},{"key":"bibr10-1759720X19858514","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"bibr11-1759720X19858514","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbr.2015.12.002"},{"key":"bibr12-1759720X19858514","doi-asserted-by":"crossref","unstructured":"Almeida AP, Fagundes NCF, Maia LC, et al. 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