{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:36:10Z","timestamp":1791866170007,"version":"4.3.4"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Dual-energy computed tomography (DECT) is being considered as a non-invasive diagnostic and characterization tool in calcium crystal-associated arthropathies. Our objective was to assess the potential of DECT in distinguishing between basic calcium phosphate (BCP) and calcium pyrophosphate (CPP) crystal deposition in and around joints in vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 13 patients with calcific periarthritis and 11 patients with crystal-proven CPPD were recruited prospectively to undergo DECT scans. Samples harvested from BCP and CPP calcification types were analyzed using Raman spectroscopy and validated against synthetic crystals. Regions of interest were placed in BCP and CPP calcifications, and the following DECT attenuation parameters were obtained: CT numbers (HU) at 80 and 140\u2009kV, dual-energy index (DEI), electron density (Rho), and effective atomic number ( Z\n                      <jats:sub>eff<\/jats:sub>\n                      ). These DECT attenuation parameters were compared and validated against crystal calibration phantoms at two known equal concentrations. Receiver operating characteristic (ROC) curves were plotted to determine the highest accuracy thresholds for DEI and Z\n                      <jats:sub>eff<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Raman spectroscopy enabled chemical fingerprinting of BCP and CPP crystals both in vitro and in vivo. DECT was able to distinguish between HA and CPP in crystal calibration phantoms at two known equal concentrations, most notably by DEI (200\u2009mg\/cm\n                      <jats:sup>3<\/jats:sup>\n                      : 0.037\u2009\u00b1\u20090 versus 0.034\u2009\u00b1\u20090, p\u2009=\u20090.008) and Z\n                      <jats:sub>eff<\/jats:sub>\n                      (200\u2009mg \/cm\n                      <jats:sup>3<\/jats:sup>\n                      : 9.4\u2009\u00b1\u20090 versus 9.3\u2009\u00b1\u20090, p\u2009=\u20090.01) analysis. Likewise, BCP calcifications had significantly higher DEI (0.041\u2009\u00b1\u20090.005 versus 0.034\u2009\u00b1\u20090.005, p\u2009=\u20090.008) and Z\n                      <jats:sub>eff<\/jats:sub>\n                      (9.5\u2009\u00b1\u20090.2 versus 9.3\u2009\u00b1\u20090.2, p\u2009=\u20090.03) than CPP crystal deposits with comparable CT numbers in patients. With an area under the ROC curve of 0.83 [best threshold value\u2009=\u20090.0 39, sensitivity\u2009=\u200990. 9% (81.8, 97. 7%), specificity\u2009=\u200964.6% (50.0, 64. 6%)], DEI was the best parameter in distinguishing between BCP and CPP crystal depositions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>DECT can help distinguish between crystal-proven BCP and CPP calcification types in vivo and, thus, aid in the diagnosis of challenging clinical cases, and in the characterization of CPP and BCP crystal deposition occurring in osteoarthritis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x20936060","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T10:50:40Z","timestamp":1592995840000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":49,"title":["Dual-energy computed-tomography-based discrimination between basic calcium phosphate and calcium pyrophosphate crystal deposition\n                    <i>in vivo<\/i>"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8395-826X","authenticated-orcid":false,"given":"Tristan","family":"Pascart","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Lille Catholic Hospitals, Saint-Philibert Hospital, University of Lille, Rue du Grand But, Lomme, F-59160, France"},{"name":"EA 4490, PMOI, Physiopathologie des Maladies Osseuses Inflammatoires, University of Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Falgayrac","sequence":"additional","affiliation":[{"name":"EA 4490, PMOI, Physiopathologie des Maladies Osseuses Inflammatoires, University of Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laur\u00e8ne","family":"Norberciak","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Biostatistics, Lille Catholic Hospitals, University of Lille, Lomme, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Lalanne","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Lille Catholic Hospitals, University of Lille, Lomme, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Legrand","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Lille Catholic Hospitals, University of Lille, Lomme, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Houvenagel","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Lille Catholic Hospitals, University of Lille, Lomme, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang-Korng","family":"Ea","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, H\u00f4pital Lariboisi\u00e8re, AP-HP, Paris, France"},{"name":"INSERM U1132, Universit\u00e9 Paris Diderot, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8444-8504","authenticated-orcid":false,"given":"Fabio","family":"Becce","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Budzik","sequence":"additional","affiliation":[{"name":"EA 4490, PMOI, Physiopathologie des Maladies Osseuses Inflammatoires, University of Lille, Lille, France"},{"name":"Department of Diagnostic and Interventional Radiology, Lille Catholic Hospitals, University of Lille, Lomme, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,24]]},"reference":[{"key":"bibr1-1759720X20936060","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0078-5"},{"key":"bibr2-1759720X20936060","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1511117"},{"key":"bibr3-1759720X20936060","first-page":"326","volume":"33","author":"Hamada J","year":"2006","journal-title":"J 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