{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:42:19Z","timestamp":1777876939100,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"AbbVie Pharmaceuticals S.A.","award":["AbbVie Pharmaceuticals S.A."],"award-info":[{"award-number":["AbbVie Pharmaceuticals S.A."]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Our aim was to evaluate the effect of adalimumab on work productivity measures, overall activity impairment, and sleep quality in patients with active moderate to severe rheumatoid arthritis (RA), psoriatic arthritis (PsA), or ankylosing spondylitis (AS) treated in routine care settings in Greece and determine factors associated with work impairment and sleep disturbance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients with active moderate to severe RA ( n\u2009=\u2009184), PsA ( n\u2009=\u2009166), and AS ( n\u2009=\u2009150) were enrolled in this 24-month, prospective, observational study at 80 hospital outpatient clinics and private practices throughout Greece. Patients received adalimumab alone or in combination with standard antirheumatic therapies according to routine care. Work productivity and sleep were assessed through two patient-reported outcome measures: the Work Productivity and Activity Impairment\u2013General Health questionnaire and the Medical Outcomes Study Sleep Scale (MOS-SS). Pearson correlation coefficients were estimated to assess the association of work impairment and sleep disturbances with disease activity scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the overall population, adalimumab significantly lowered absenteeism [mean (95% confidence interval) reduction, 18.9% (13.3\u201324.5%); n\u2009=\u2009100]; presenteeism [40.0% (33.8\u201346.3%); n\u2009=\u200998], overall work productivity impairment [46.8% (40.4\u201353.2%); n\u2009=\u200994], activity impairment [47.0% (44.3\u201349.6); n\u2009=\u2009421], and the MOS-SS sleep problems index [31.6 (29.5\u201334.1); n\u2009=\u2009421] after 24-month treatment ( p\u2009&lt;\u20090.001). Significant improvements were also noted across the RA, PsA, and AS subpopulations ( p\u2009&lt;\u20090.05). Improvements in overall work impairment and sleep disturbance positively correlated with improvements in disease activity measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Adalimumab improves work productivity and sleep problems while lowering disease activity in patients with moderate to severe RA, PsA, and AS managed in real-world settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x20949088","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T03:33:11Z","timestamp":1601263991000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Real-world evidence of the impact of adalimumab on work productivity and sleep measures in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2238-0975","authenticated-orcid":false,"given":"Maria G.","family":"Tektonidou","sequence":"first","affiliation":[{"name":"1st Department of Propaedeutic and Internal Medicine, Joint Rheumatology Program, Laiko Hospital, Medical School, National and Kapodistrian University of Athens, 17 Agiou Thoma Str., Athens, 11 527, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gkikas","family":"Katsifis","sequence":"additional","affiliation":[{"name":"Rheumatology Clinic Naval Hospital of Athens, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios","family":"Georgountzos","sequence":"additional","affiliation":[{"name":"Rheumatology Department, G.Gennimatas General Hospital, Athens, Attica, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athina","family":"Theodoridou","sequence":"additional","affiliation":[{"name":"Academic Research Fellow Hippokration Hospital Thessaloniki, Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eftychia-Maria","family":"Koukli","sequence":"additional","affiliation":[{"name":"Rheumatologist, Private practice, Kifissia, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kandili","sequence":"additional","affiliation":[{"name":"Rheumatologist, Metropolitan general Hospital Athens, Cholargos, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giasna","family":"Giokic-Kakavouli","sequence":"additional","affiliation":[{"name":"Rheumatologist, Private practice, Karterini, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4928-8853","authenticated-orcid":false,"given":"Theofilos-Diamantis","family":"Karatsourakis","sequence":"additional","affiliation":[{"name":"employee of AbbVie Pharmaceuticals S.A., Neo Iraklio, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,9,28]]},"reference":[{"key":"bibr1-1759720X20949088","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh650"},{"key":"bibr2-1759720X20949088","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-11-98"},{"key":"bibr3-1759720X20949088","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel140"},{"key":"bibr4-1759720X20949088","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker385"},{"key":"bibr5-1759720X20949088","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.05.010"},{"key":"bibr6-1759720X20949088","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2015.06.001"},{"key":"bibr7-1759720X20949088","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-0977-2"},{"key":"bibr8-1759720X20949088","doi-asserted-by":"publisher","DOI":"10.1186\/ar4054"},{"key":"bibr9-1759720X20949088","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-012-2513-2"},{"key":"bibr10-1759720X20949088","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12505"},{"key":"bibr11-1759720X20949088","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.161330"},{"key":"bibr12-1759720X20949088","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-016-3589-x"},{"key":"bibr13-1759720X20949088","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-2875-4"},{"key":"bibr14-1759720X20949088","first-page":"603","volume":"56","author":"Tillett 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