{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T20:47:17Z","timestamp":1778791637511,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Hospital Clinic of Barcelona, Research, Innovation and Education Department","award":["37933"],"award-info":[{"award-number":["37933"]}]},{"name":"European Regional Development Fund\/Spanish Ministry of Economy, Industry and Competitiveness","award":["RTI2018-094120-B-I00"],"award-info":[{"award-number":["RTI2018-094120-B-I00"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>A restricted response against citrullinated peptides\/proteins, with less isotype usage, has been found in palindromic rheumatism (PR) in comparison with rheumatoid arthritis (RA). We hypothesized that this different antibody response may be observed for other post-translational modified proteins. We compared the prevalence and isotype usage of two specificities of anti-carbamylated peptide\/protein antibodies (Anti-CarP) in patients with PR and RA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Cross-sectional study including 54 patients with pure PR and 53 patients with RA, matched by sex, age, disease duration and ACPA. Anti-CarP specificities were determined by home-made enzyme-linked immunosorbent assay tests using a synthetic chimeric fibrin\/filaggrin homocitrullinated peptide (CFFHP) and fetal calf serum (FCS) homocitrullinated protein as antigens. IgG, IgA and IgM isotypes were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Anti-CarP were positive (CFFHP or FCS) in 24% and 64% of patients with PR and RA, respectively ( p\u2009&lt;\u20090.005). All Anti-CarP isotype proportions were significantly lower in PR than in RA: Anti-CarP-IgG (24% versus 51%), Anti-CarP-IgA (7% versus 34%) and Anti-CarP-IgM (7% versus 36%). Mean titers of Anti-CarP isotypes were also lower in PR. In Anti-CarP positive patients, the isotype distribution differed between PR and RA: IgG Anti-CarP was used in all PR patients and in 79% of RA patients. By contrast, a significantly lower isotype usage of both IgA (31% versus 53%) and IgM (31% versus 56%) was observed in PR patients. No significant differences in clinical or demographic characteristics were observed according to Anti-CarP status in PR patients, except for a higher prevalence of ACPA and higher mean titers of ACPA and rheumatoid factor in Anti-CarP positive patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Anti-CarP are found in patients with PR but in a lower proportion and with a different isotype usage from in RA, suggesting a distinct B cell response to homocitrullinated antigens in PR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x20978139","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T02:11:20Z","timestamp":1607652680000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Anti-carbamylated protein antibody isotype pattern differs between palindromic rheumatism and rheumatoid arthritis"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4104-4101","authenticated-orcid":false,"given":"Raul","family":"Castellanos-Moreira","sequence":"first","affiliation":[{"name":"Arthritis Unit, Rheumatology Department, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian C.","family":"Rodriguez-Garcia","sequence":"additional","affiliation":[{"name":"Arthritis Unit, Rheumatology Department, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Cabrera-Villalba","sequence":"additional","affiliation":[{"name":"Arthritis Unit, Rheumatology Department, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Gomara","sequence":"additional","affiliation":[{"name":"Unit of Synthesis and Biomedical Applications of Peptides, Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Cient\u00edficas (IQAC-CSIC), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina","family":"Salvador","sequence":"additional","affiliation":[{"name":"Rheumatology Department, University Hospital Mutua Tarrasa, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Ruiz-Esquide","sequence":"additional","affiliation":[{"name":"Arthritis Unit, Rheumatology Department, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7047-8056","authenticated-orcid":false,"given":"Julio","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Arthritis Unit, Rheumatology Department, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Inciarte-Mundo","sequence":"additional","affiliation":[{"name":"Arthritis Unit, Rheumatology Department, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Morla","sequence":"additional","affiliation":[{"name":"Arthritis Unit, Rheumatology Department, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Garcia-Moreno","sequence":"additional","affiliation":[{"name":"Unit of Synthesis and Biomedical Applications of Peptides, Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Cient\u00edficas (IQAC-CSIC), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Cuervo","sequence":"additional","affiliation":[{"name":"Arthritis Unit, Rheumatology Department, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose A.","family":"G\u00f3mez-Puerta","sequence":"additional","affiliation":[{"name":"Arthritis Unit, Rheumatology Department, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan D.","family":"Ca\u00f1ete","sequence":"additional","affiliation":[{"name":"Arthritis Unit, Rheumatology Department, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Haro","sequence":"additional","affiliation":[{"name":"Unit of Synthesis and Biomedical Applications of Peptides, Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Cient\u00edficas (IQAC-CSIC), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8864-3806","authenticated-orcid":false,"given":"Raimon","family":"Sanmarti","sequence":"additional","affiliation":[{"name":"Arthritis Unit, Rheumatology Department, Hospital Clinic of Barcelona, Villarroel 170, Barcelona, 08036, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,12,10]]},"reference":[{"key":"bibr1-1759720X20978139","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2004.05.005"},{"key":"bibr2-1759720X20978139","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0308-5"},{"key":"bibr3-1759720X20978139","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg268"},{"key":"bibr4-1759720X20978139","first-page":"1240","volume":"33","author":"Russell AS","year":"2006","journal-title":"J 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