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The most common complaints are pain, limited mobility, crepitus, difficulty climbing and descending stairs, and joint instability, usually showing unsatisfactory results with anti-inflammatory, physiotherapy, rehabilitation, and many other conservative treatment methods. The presumed hyaluronic acid (HA) disease-modifying activity may include effects on cartilage degradation, endogenous HA synthesis, synoviocyte and chondrocyte function, and other cellular inflammatory processes. Currently, HA is widely used as a safe and effective conservative treatment for osteoarthritis in the knee and other joints. HA improves the physiological environment in an osteoarthritic joint and the shock absorption and lubrication properties of the osteoarthritic synovial fluid, thus restoring the protective viscoelasticity of the synovial HA, reducing the pain, and improving the mobility. The complete mechanism of HA in the joint is not fully understood, but a wide range of actions in the joint is recognized. Its anti-inflammatory, analgesic, and chondroprotective action is related to the modulation of the intra- and extracellular inflammation cascade. HA has been shown to be safe and effective in the treatment of pain related to patellar chondropathy.<\/jats:p>","DOI":"10.1177\/1759720x211015005","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T02:16:12Z","timestamp":1620958572000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["The role of viscosupplementation in patellar chondropathy"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7224-0319","authenticated-orcid":false,"given":"Sergio Ricardo","family":"da Costa","sequence":"first","affiliation":[{"name":"PhD Program for Musculoskeletal System Sciences, Instituto de Ortopedia e Traumatologia, Hospital das cl\u00ednicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, 333 Ov\u00eddio Pires de Campos St., Cerqueira C\u00e9sar, S\u00e3o Paulo, SP 05403-010, 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