{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T19:43:17Z","timestamp":1784835797030,"version":"3.55.0"},"reference-count":54,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"instituto de salud carlos iii","doi-asserted-by":"publisher","award":["CPII17\/00014"],"award-info":[{"award-number":["CPII17\/00014"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"instituto de salud carlos iii","doi-asserted-by":"publisher","award":["RD16\/0012\/0014"],"award-info":[{"award-number":["RD16\/0012\/0014"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Rheumatic and musculoskeletal diseases (RMDs) have a significant impact on patients\u2019 health-related quality of life (HRQoL) exacerbating disability, reducing independence and work capacity, among others. Predictors\u2019 identification affecting HRQoL could help to place efforts that minimize the deleterious impact of these conditions on patients\u2019 wellbeing. This study evaluates the influence of demographic and clinical predictors on the HRQoL of a cohort of RMD patients, measured using the Rosser classification index (RCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We included patients attending the Hospital Cl\u00ednico San Carlos (HCSC) rheumatology outpatient clinic from 1 April 2007 to 30 November 2017. The primary outcome was the HRQoL assessed in each of the patient\u2019s visits using the RCI. Demographic and clinical variables extracted from a departmental electronic health record (EHR) were used as predictors: RMD diagnoses, treatments, comorbidities, and averaged HRQoL values from previous periods (for this last variable, values were imputed if no information was available). Association between predictors and HRQoL was analyzed using penalized generalized estimating equations (PGEEs). To account for imputation bias, the PGEE model was repeated excluding averaged HRQoL predictors, and common predictors were considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>A total of 18,187 outpatients with 95,960 visits were included. From 410 initial predictors, 19 were independently associated with patients\u2019 HRQoL in both PGEE models. Chronic kidney disease (CKD), an episode of prescription of third level analgesics, monoarthritis, and fibromyalgia diagnoses were associated with worse HRQoL. Conversely, the prescription in the previous visit of acid-lowering medication, colchicine, and third level analgesics was associated with better HRQoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We have identified several diagnoses, treatments, and comorbidities independently associated with HRQoL in a cohort of outpatients attending a rheumatology clinic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x211034063","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:55:22Z","timestamp":1627260922000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictors of health-related quality of life in musculoskeletal disease patients: a longitudinal analysis"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1591-0467","authenticated-orcid":false,"given":"Alfredo","family":"Madrid-Garc\u00eda","sequence":"first","affiliation":[{"name":"Grupo de Patolog\u00eda Musculoesquel\u00e9tica, Hospital Cl\u00ednico San Carlos, IdISSC, Madrid, Spain"},{"name":"Escuela T\u00e9cnica Superior de Ingenieros de Telecomunicaci\u00f3n (ETSIT), Universidad Polit\u00e9cnica de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Le\u00f3n-Mateos","sequence":"additional","affiliation":[{"name":"Grupo de Patolog\u00eda Musculoesquel\u00e9tica, Hospital Cl\u00ednico San Carlos, IdISSC, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza","family":"Pato","sequence":"additional","affiliation":[{"name":"Rheumatology Service, Hospital Cl\u00ednico San Carlos, IdISSC, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A","family":"Jover","sequence":"additional","affiliation":[{"name":"Rheumatology Service, Hospital Cl\u00ednico San Carlos, IdISSC, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6126-8786","authenticated-orcid":false,"given":"Benjam\u00edn","family":"Fern\u00e1ndez-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Rheumatology Service, Hospital Cl\u00ednico San Carlos, IdISSC, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Abasolo","sequence":"additional","affiliation":[{"name":"Grupo de Patolog\u00eda Musculoesquel\u00e9tica, Hospital Cl\u00ednico San Carlos, IdISSC, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernestina","family":"Menasalvas","sequence":"additional","affiliation":[{"name":"Centro de Tecnolog\u00eda Biom\u00e9dica, Universidad Polit\u00e9cnica de Madrid, Parque Cient\u00edfico y Tecnol\u00f3gico de la UPM, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2869-7861","authenticated-orcid":false,"given":"Luis","family":"Rodr\u00edguez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Grupo de Patolog\u00eda Musculoesquel\u00e9tica, Hospital Cl\u00ednico San Carlos, c\\ Prof. Martin Lagos s\/n, Madrid 28040, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,25]]},"reference":[{"key":"bibr1-1759720X211034063","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603283341306"},{"key":"bibr2-1759720X211034063","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-8-199304150-00009"},{"key":"bibr3-1759720X211034063","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.010769"},{"key":"bibr4-1759720X211034063","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcmj.2012.09.002"},{"key":"bibr5-1759720X211034063","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32279-7"},{"key":"bibr6-1759720X211034063","first-page":"159","volume":"35","author":"Loza E","year":"2008","journal-title":"J 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