{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:00:03Z","timestamp":1790420403536,"version":"4.1.0"},"reference-count":58,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"SUBLIMED"},{"name":"Laboratoires Expanscience"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Despite their poor tolerance, especially in the elderly, weak opioids (WO) remain commonly prescribed for patients with knee osteoarthritis (KOA). We compared the efficacy and safety of a new wearable transcutaneous electrical nerve stimulation (W-TENS) device with WO for the treatment of moderate-to-severe, nociceptive KOA chronic pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study was a non-inferiority, multicentric, prospective, randomized, single-blind, controlled, 2-parallel groups Trial. A total of 110 patients with KOA were included (Kellgren-Lawrence radiographic grade \u2a7e2; American College of Rheumatology criteria), with chronic moderate-to-severe nociceptive pain (mean 8-day pain intensity (PI) \u2a7e 4 on an 11-point numerical rating scale), in failure to non-opioid analgesics, including nonsteroidal anti-inflammatory drugs (NSAIDs). Patients with neuropathic pain were excluded. The co-primary endpoints were mean PI at 3 months (M3) and number of potentially treatment-related adverse events (TRAEs). Secondary outcomes included Western Ontario MAC Master University function subscale (range, 0\u201368), additional pain and quality of life measures, and responder rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The non-inferiority of W-TENS was demonstrated in both the per protocol (PP) and intent-to-treat (ITT) populations. At M3, PI in PP population was 3.87 (2.12) compared with 4.66 (2.37) [delta: \u22120.79 (0.44); 95% CI (\u22121.65, 0.08)] in W-TENS and WO groups, respectively. A planned superiority analysis showed a significant superiority of W-TENS over WO on PI at M3 ( p = 0.0124). The number of TRAEs was significantly lower in the W-TENS group ( n = 7) than in the WO group ( n = 36) ( p &lt; 0.001). Other secondary outcomes also favored W-TENS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>W-TENS was more effective and better tolerated than WO in the treatment of chronic nociceptive KOA pain and offers an interesting non-pharmacological analgesic alternative in the management of KOA. Trial Registration: ClinicalTrials.gov: NCT03902340<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x211066233","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:47Z","timestamp":1642550447000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Wearable transcutaneous electrical nerve stimulation (actiTENS\u00ae) is effective and safe for the treatment of knee osteoarthritis pain: a randomized controlled trial\n                    <i>versus<\/i>\n                    weak opioids"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6615-3630","authenticated-orcid":false,"given":"Emmanuel","family":"Maheu","sequence":"first","affiliation":[{"name":"Rheumatology Department, St-Antoine Hospital\u2013APHP, 75011 Paris, FrancePrivate Office, 283, Bd Voltaire, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Soriot-Thomas","sequence":"additional","affiliation":[{"name":"Clinical Research Centre and Orthopaedic and Traumatology Surgery Department, CHU Amiens Picardie, Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Noel","sequence":"additional","affiliation":[{"name":"Rheumatologist, Ramsay Sant\u00e9, H\u00f4pital Priv\u00e9 Jean Mermoz, Centre Orthop\u00e9dique Santy, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Ganry","sequence":"additional","affiliation":[{"name":"Hergan Consulting 4U, Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Lespessailles","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Regional Hospital of Orleans, University of Orl\u00e9ans, Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Cortet","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Centre Hospitalier Universitaire de Lille, 59000 Lille, 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