{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T10:59:02Z","timestamp":1793271542611,"version":"4.5.0"},"reference-count":139,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Psoriatic arthritis (PsA) is associated with a higher burden of cardiometabolic disorders, such as hypertension, dyslipidemia, diabetes, obesity, and cardiovascular disease (CVD), compared with the general population. These comorbidities are associated with the severity of disease, and adversely affect treatment outcomes in PsA. Comorbidities lead to increased physician visits and medications for patients and make the selection and maintenance of therapies challenging for physicians. Moreover, CVD is a leading cause of mortality in PsA. Therefore, optimal management of PsA should include not only treating the skin and joint disease, but also identifying comorbidities early, and managing them to improve long-term outcomes. Further studies are needed to understand the complex mechanisms, interactions, and trajectories of cardiometabolic comorbidities in psoriatic disease.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Plain Language Summary<\/jats:title>\n                    <jats:p>Psoriatic arthritis and the association with cardiometabolic disease Psoriatic arthritis (PsA) is associated with a higher incidence and prevalence of cardiometabolic comorbidities compared with the general population, and higher than psoriasis and other inflammatory arthritides, such as rheumatoid arthritis and other spondyloarthritides. Obesity and hyperlipidemia are associated with an increased risk of developing PsA. Cardiometabolic comorbidities in PsA are associated with more severe disease and a lower likelihood of response to therapy. Suggested approaches to improve screening and management of CVD in PsA include education of family physicians and relevant specialists, development of mechanisms to improve communication between the rheumatologists and primary care providers, and novel models of care, including interdisciplinary cardio-rheumatology clinics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x21998279","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T01:38:15Z","timestamp":1614735495000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":74,"title":["Psoriatic arthritis and the association with cardiometabolic disease: a narrative review"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1034-1530","authenticated-orcid":false,"given":"Paras","family":"Karmacharya","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4639-0775","authenticated-orcid":false,"given":"Alexis","family":"Ogdie","sequence":"additional","affiliation":[{"name":"Departments of Medicine\/Rheumatology and Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihi","family":"Eder","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Rheumatology, Women\u2019s College Hospital, University of Toronto, 27 King\u2019s College Cir, Toronto, ON M5S, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"key":"bibr1-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1505557"},{"key":"bibr2-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-7-25"},{"key":"bibr3-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.121500"},{"key":"bibr4-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23094"},{"key":"bibr5-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205675"},{"key":"bibr6-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20627"},{"key":"bibr7-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22926"},{"key":"bibr8-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207980"},{"key":"bibr9-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/714321"},{"key":"bibr10-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20363"},{"key":"bibr11-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-9-48"},{"key":"bibr12-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.169404"},{"key":"bibr13-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23171"},{"key":"bibr14-1759720X21998279","unstructured":"Centers for Disease Control and Prevention. Data & Statistics. Diabetes. National Diabetes Statistics Report, https:\/\/www.cdc.gov\/diabetes\/data\/statistics\/statistics-report.html (2020, accessed 2 August 2020)."},{"key":"bibr15-1759720X21998279","unstructured":"International Diabetes Federation. IDF diabetes atlas. 9th ed, https:\/\/www.diabetesatlas.org\/en\/ (2019, accessed 2 August 2020)."},{"key":"bibr16-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.11.035"},{"key":"bibr17-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2009.02845.x"},{"key":"bibr18-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-020-00206-7"},{"key":"bibr19-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3362-2"},{"key":"bibr20-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2015.07.008"},{"key":"bibr21-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket343"},{"key":"bibr22-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.160861"},{"key":"bibr23-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/580404"},{"key":"bibr24-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12473"},{"key":"bibr25-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03947.x"},{"key":"bibr26-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22185"},{"key":"bibr27-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04528-y"},{"key":"bibr28-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016400"},{"key":"bibr29-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019303"},{"key":"bibr30-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-010-3408-1"},{"key":"bibr31-1759720X21998279","first-page":"2167","volume":"33","author":"Han C","year":"2006","journal-title":"J Rheumatol"},{"key":"bibr32-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.135871"},{"key":"bibr33-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.11.904"},{"key":"bibr34-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken090"},{"key":"bibr35-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1002\/art.24014"},{"key":"bibr36-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1002\/art.22884"},{"key":"bibr37-1759720X21998279","first-page":"877","volume":"35","author":"Eder L","year":"2008","journal-title":"J Rheumatol"},{"key":"bibr38-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05132-1"},{"key":"bibr39-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2018.74021"},{"key":"bibr40-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12921"},{"key":"bibr41-1759720X21998279","unstructured":"Hales CM, Carroll MD, Fryar CD, et al. Prevalence of obesity among adults and youth: United States, 2015\u20132016. Centers for Disease Control and Prevention. National Center for Health Statistics. Products - Data Briefs - Number 288, https:\/\/www.cdc.gov\/nchs\/products\/databriefs\/db288.htm (2019, accessed 2 August 2020)."},{"key":"bibr42-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22536"},{"key":"bibr43-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08707.x"},{"key":"bibr44-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2012.26"},{"key":"bibr45-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1358-1"},{"key":"bibr46-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1089\/met.2009.0124"},{"key":"bibr47-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.5888\/pcd14.160287"},{"key":"bibr48-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-014-8595-z"},{"key":"bibr49-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.141359"},{"key":"bibr50-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210579"},{"key":"bibr51-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0175-0"},{"key":"bibr52-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1002\/art.39494"},{"key":"bibr53-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201299"},{"key":"bibr54-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201273"},{"key":"bibr55-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.4610"},{"key":"bibr56-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21955"},{"key":"bibr57-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17741"},{"key":"bibr58-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18227"},{"key":"bibr59-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.160532"},{"key":"bibr60-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23229"},{"key":"bibr61-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew326"},{"key":"bibr62-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.190219."},{"key":"bibr63-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204448"},{"key":"bibr64-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140021"},{"key":"bibr65-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21711"},{"key":"bibr66-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195123"},{"key":"bibr67-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.171034"},{"key":"bibr68-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2018.1528000"},{"key":"bibr69-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217251."},{"key":"bibr70-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010058"},{"key":"bibr71-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206624"},{"key":"bibr72-1759720X21998279","first-page":"769","volume-title":"Lancet","volume":"382","author":"Coxib and Traditional NSAID Trialists\u2019 (CNT) Collaboration","year":"2013"},{"key":"bibr73-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209775"},{"key":"bibr74-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.125476"},{"key":"bibr75-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.878"},{"key":"bibr76-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02429.x"},{"key":"bibr77-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2008.02.006"},{"key":"bibr78-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1185\/03007990903162465"},{"key":"bibr79-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2369-1"},{"key":"bibr80-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1186\/s41927-020-00138-3"},{"key":"bibr81-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1002\/art.34335"},{"key":"bibr82-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.2502"},{"key":"bibr83-1759720X21998279","first-page":"899","volume":"12","author":"Wu JJ","year":"2013","journal-title":"J Drugs Dermatol"},{"key":"bibr84-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10774.x"},{"key":"bibr85-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2001"},{"key":"bibr86-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.094839"},{"key":"bibr87-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1002\/art.40389"},{"key":"bibr88-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205267"},{"key":"bibr89-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212189"},{"key":"bibr90-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080314"},{"key":"bibr91-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.5603\/KP.a2015.0028"},{"key":"bibr92-1759720X21998279","first-page":"S11","volume":"20","author":"Lautermann D","year":"2002","journal-title":"Clin Exp Rheumatol"},{"key":"bibr93-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2019.05.005"},{"key":"bibr94-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015343"},{"key":"bibr95-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2019.82678"},{"key":"bibr96-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1159\/000365760"},{"key":"bibr97-1759720X21998279","volume":"71","author":"Koppikar S","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"bibr98-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-020-01349-3"},{"key":"bibr99-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.4081\/monaldi.2018.934"},{"key":"bibr100-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1177\/0003319717699329"},{"key":"bibr101-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23611"},{"key":"bibr102-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707914"},{"key":"bibr103-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912388"},{"key":"bibr104-1759720X21998279","first-page":"932","volume":"13","author":"Wu JJ","year":"2014","journal-title":"J Drugs Dermatol"},{"key":"bibr105-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1002\/art.40366"},{"key":"bibr106-1759720X21998279","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/j.1468-3083.2012.04705.x","volume":"27","author":"Langley RG","year":"2013","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"bibr107-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.07.679"},{"key":"bibr108-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.006283"},{"key":"bibr109-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14964"},{"key":"bibr110-1759720X21998279","first-page":"1002","volume":"16","author":"Bissonnette R","year":"2017","journal-title":"J Drugs Dermatol"},{"key":"bibr111-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.0001"},{"key":"bibr112-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2019.06.021"},{"key":"bibr113-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17454"},{"key":"bibr114-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.03.024"},{"key":"bibr115-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-018-0651-5"},{"key":"bibr116-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-020-00209-4"},{"key":"bibr117-1759720X21998279","first-page":"45","volume":"63","author":"Hu T","year":"2017","journal-title":"Can Fam Physician"},{"key":"bibr118-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.06.035"},{"key":"bibr119-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14557"},{"key":"bibr120-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208174"},{"key":"bibr121-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203433."},{"key":"bibr122-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170025"},{"key":"bibr123-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1002\/art.40925"},{"key":"bibr124-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205506"},{"key":"bibr125-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.113696"},{"key":"bibr126-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.190261"},{"key":"bibr127-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170379"},{"key":"bibr128-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2015-000152"},{"key":"bibr129-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.2217\/ijr.15.45"},{"key":"bibr130-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202812"},{"key":"bibr131-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12460"},{"key":"bibr132-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2012.05.002"},{"key":"bibr133-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21197"},{"key":"bibr134-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12886"},{"key":"bibr135-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12629"},{"key":"bibr136-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.11.003"},{"key":"bibr137-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"bibr138-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.03.010"},{"key":"bibr139-1759720X21998279","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211253"}],"container-title":["Therapeutic Advances in Musculoskeletal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1759720X21998279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1759720X21998279","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1759720X21998279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:38:10Z","timestamp":1777588690000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1759720X21998279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":139,"alternative-id":["10.1177\/1759720X21998279"],"URL":"https:\/\/doi.org\/10.1177\/1759720x21998279","relation":{},"ISSN":["1759-720X","1759-7218"],"issn-type":[{"value":"1759-720X","type":"print"},{"value":"1759-7218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"1759720X21998279"}}