{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T07:50:35Z","timestamp":1785657035902,"version":"3.56.0"},"reference-count":52,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011772","name":"novartis farmac\u00e9utica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011772","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To evaluate, in a multicentric Italian cohort of axial spondyloarthritis (axSpA) patients on Secukinumab (SEC) followed for 24 months: (1) the long-term effectiveness and safety of SEC; (2) the drug retention rate and low disease activity (LDA) measured as Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)\u2009&lt;\u20094\/Ankylosing Spondylitis Disease Activity Score (ASDAS)\u2009&lt;\u20092.1 and very low disease activity (VLDA) measured as BASDAI\u2009&lt;\u20092\/ASDAS\u2009&lt;\u20091.3; (3) any differences in outcomes according to line of biological treatment (na\u00efve\/non-na\u00efve), gender (male\/female), subtype of axSpA [radiographic axSpA (r-axSpA)\/non-radiographic axSpA (nr-axSpA)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Consecutive axSpA patients treated with SEC were evaluated prospectively. Disease characteristics, previous\/ongoing treatments, comorbidities, and follow-up duration were collected. Disease activity\/functional\/clinimetric scores and biochemical-values were recorded at baseline (T0), 6 (T6), 12 (T12), and 24 (T24) months. Effectiveness was evaluated over-time with descriptive statistics; multivariate Cox and logistic regression models were used to evaluate predictors of drug discontinuation and LDA at T6. Infections and adverse events were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total 249 patients (47.8% male; median age 51) were enrolled; 40.9% had HLA-B27; 53.8% had r-axSpA, and 46.2% nr-axSpA. SEC was prescribed in 28.9% na\u00efve and in 71.1% non-na\u00efve patients. SEC effectiveness was shown as an improvement in several outcomes, such as ASDAS [T0\u2009=\u20093.5 (2.9\u20134.4) versus T24\u2009=\u20091.9 (1.2\u20132.4); p\u2009=\u20090.02] and BASDAI [T0\u2009=\u20096.5 (5.0\u20137.5) versus T24\u2009=\u20092.8 (1.8\u20134.0); p\u2009=\u20090.03]. At T24, na\u00efve patients showed better physical functioning and lower disease activity than non-na\u00efve. After 24 months of treatment, 90.7% of na\u00efve and 75.3% of non-na\u00efve patients achieved LDA (BASDAI\u2009&lt;\u20094). Treatment was discontinued in 24.5% patients, mainly due to primary\/secondary loss of effectiveness, and in 6.8% due to adverse events. Retention rate at T24 was 75% in the whole population, with some difference depending on gender ( p\u2009=\u20090.002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In a real-life clinical setting, SEC proved to be safe and effective in axSpA, mainly in na\u00efve-patients, with a notable drug retention rate. No differences were observed between r-axSpA and nr-axSpA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x221090310","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T03:23:07Z","timestamp":1651202587000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Effectiveness and safety of secukinumab in axial spondyloarthritis: a 24-month prospective, multicenter real-life study"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9683-8873","authenticated-orcid":false,"given":"Roberta","family":"Ramonda","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Medicine (DIMED), University of Padova, Via Giustiniani, 2, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariagrazia","family":"Lorenzin","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine (DIMED), University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1343-1729","authenticated-orcid":false,"given":"Maria","family":"Sole Chimenti","sequence":"additional","affiliation":[{"name":"Rheumatology, Allergology and Clinical Immunology, Department of \u2018Medicina dei Sistemi\u2019, University of Rome \u2018Tor Vergata\u2019, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7442-1110","authenticated-orcid":false,"given":"Salvatore","family":"D\u2019Angelo","sequence":"additional","affiliation":[{"name":"Rheumatology Institute of Lucania (IReL), Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Potenza Local Health System, Potenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Marchesoni","sequence":"additional","affiliation":[{"name":"Rheumatology, Humanitas San Pio X, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Salvarani","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Internal Medicine, Azienda USL-IRCCS, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy"},{"name":"University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6189-5328","authenticated-orcid":false,"given":"Ennio","family":"Lubrano","sequence":"additional","affiliation":[{"name":"Academic Rheumatology Unit, Dipartimento di Medicina e Scienze per la Salute \u2018Vincenzo Tiberio\u2019, University of Molise, Campobasso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Costa","sequence":"additional","affiliation":[{"name":"Rheumatology Research Unit, Department of Clinical Medicine and Surgery, School of Medicine and Surgery, University of Naples FEDERICO II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ylenia","family":"Dal Bosco","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, A.O.U. 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