{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:39:18Z","timestamp":1793367558856,"version":"4.5.0"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To analyse the accuracy of plasma calprotectin in patients with rheumatoid arthritis (RA) receiving monoclonal antibodies against IL-6 receptors (anti-rIL-6) or JAK inhibitors (JAKis) in detecting ultrasound (US) synovitis and compare it with acute phase reactants [high-sensitivity C-reactive protein (hs-CRP) and ESR].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>An observational cross-sectional study of RA patients receiving anti-rIL-6 (tocilizumab or sarilumab) or JAKi, (baricitinib or tofacitinib) was made. Plasma calprotectin for the diagnosis of US synovitis [synovial hypertrophy grade (SH)\u2009\u2a7e\u20092 plus power Doppler signal (PD)\u2009\u2a7e\u20091] was analysed using receiver operating characteristic curves (ROCs). The performance of ESR and hs-CRP was also studied. The three ROC curves were compared to determine which had the highest discriminatory power. Associations between plasma calprotectin and US scores were made using correlation analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Sixty-three RA patients were included. Mean plasma calprotectin levels were significantly higher in patients with US synovitis than in those without (0.89\u2009\u00b1\u20090.85 vs 0.30\u2009\u00b1\u20090.12 \u03bcg\/ml; p\u2009=\u20090.0003). A moderate correlation between calprotectin and all US scores (HS score Rho\u2009=\u20090.479; PD score Rho\u2009=\u20090.492; and global score Rho\u2009=\u20090.495) was found. The discriminatory capacity of plasma calprotectin showed an AUC of 0.795 (95% CI: 0.687\u20130.904). The AUC of hs-CRP and ESR was 0.721 and 0.564, respectively. hs-CRP serum levels showed a low positive correlation with the three US scores (Rho\u2009&lt;\u20090.40). After analysis according to the drugs administered, the correlation disappeared in patients receiving anti-rIL-6.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Plasma calprotectin may be a sensitive biomarker of synovial inflammation in RA patients treated with anti-rIL-6 or JAKi.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x221114105","type":"journal-article","created":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T08:32:06Z","timestamp":1663403526000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Plasma calprotectin as a biomarker of ultrasound synovitis in rheumatoid arthritis patients receiving IL-6 antagonists or JAK inhibitors"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5867-8434","authenticated-orcid":false,"given":"Beatriz","family":"Frade-Sosa","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3068-5752","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Ponce","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Inciarte-Mundo","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Cl\u00ednic per a la Recerca Biom\u00e9dica, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Morl\u00e0","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2657-6601","authenticated-orcid":false,"given":"Viginia","family":"Ruiz-Esquide","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mac\u00edas","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetics Department, Hospital Cl\u00ednic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Belen","family":"Azuaga","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan D.","family":"Ca\u00f1ete","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Yague","sequence":"additional","affiliation":[{"name":"Department of Immunology, Hospital Clinic \u2013 CDB, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep M.","family":"Auge","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetics Department, Hospital Cl\u00ednic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8177-702X","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Gomez-Puerta","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Clinic of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8864-3806","authenticated-orcid":false,"given":"Raimon","family":"Sanmarti","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Clinic of Barcelona, Carrer Villarroel 170, Barcelona 08170, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,9,17]]},"reference":[{"key":"bibr1-1759720X221114105","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-216655"},{"key":"bibr2-1759720X221114105","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.08.001"},{"key":"bibr3-1759720X221114105","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key225"},{"key":"bibr4-1759720X221114105","doi-asserted-by":"publisher","DOI":"10.1186\/ar565"},{"key":"bibr5-1759720X221114105","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-021-05815-3"},{"key":"bibr6-1759720X221114105","doi-asserted-by":"publisher","DOI":"10.1002\/art.27740"},{"key":"bibr7-1759720X221114105","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0058-9"},{"key":"bibr8-1759720X221114105","first-page":"2523","volume":"26","author":"Youssef P","year":"1999","journal-title":"J 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