{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T11:54:43Z","timestamp":1793361283492,"version":"4.5.0"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The value of normal C-reactive protein (CRP) in psoriatic arthritis (PsA) is debatable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To test the hypothesis that CRP is frequently normal in contemporary real-world PsA patients, despite active disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>In this cross-sectional study, patients were divided into two groups: CRP\u2009\u2a7d\u20090.5\u2009mg\/dl (normal) and CRP\u2009&gt;\u20090.5\u2009mg\/dl (increased). Having as dependent variable the CRP status, these groups were compared for disease-related features, including composite disease activity indices [clinical Disease Activity in PSoriatic Arthritis (cDAPSA) and minimal disease activity (MDA)] and patient-reported outcomes (PROs). Agreement between CRP status and cDAPSA\/MDA scores was calculated (Cohen\u2019s kappa).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data from consecutive PsA patients attending two outpatient rheumatology clinics (January 2019\u2013June 2021) were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>From 128 patients enrolled (51.6% females; mean\u2009\u00b1\u2009standard deviation age: 53.4\u2009\u00b1\u200911.7\u2009years; 23.4%, 48.4% and 64.1% treated with glucocorticoids, conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) and biologic DMARDs, respectively), two-thirds (66.4%, n\u2009=\u200985) had normal CRP values. CRP status was not associated with any of the disease-related parameters and PROs, but only with ESR [odds ratio: 1.04 (95% confidence interval: 1.01\u20131.06), p\u2009=\u20090.005]. Among patients with normal CRP, 45.9% (39\/85) were on non-MDA state, while 21.2% (18\/85) had cDAPSA-moderate and 5.9% (5\/85) had cDAPSA-high disease activities. Conversely, 54.2% (39\/72) of patients on non-MDA state and 52.3% (23\/44) of those with cDAPSA-moderate or cDAPSA-high disease activity had normal CRP values. Cohen\u2019s kappa between normal CRP and MDA, cDAPSA-remission, and cDAPSA-remission\/low disease activity was \u20130.26, \u20130.21 and \u20130.22, respectively, displaying total disagreement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Normal CRP in PsA should not be used as surrogate marker of remission or low\/MDA, therefore needs to be interpreted with caution in clinical decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x221122417","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T03:06:23Z","timestamp":1662347183000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Normal C-reactive protein in active psoriatic arthritis: results from real-world clinical practice"],"prefix":"10.1177","volume":"14","author":[{"given":"Chrysoula G.","family":"Gialouri","sequence":"first","affiliation":[{"name":"Joint Academic Rheumatology Program, Rheumatology Unit, First Department of Propaedeutic Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerasimos","family":"Evangelatos","sequence":"additional","affiliation":[{"name":"Joint Academic Rheumatology Program, Rheumatology Unit, First Department of Propaedeutic Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Pappa","sequence":"additional","affiliation":[{"name":"Joint Academic Rheumatology Program, Rheumatology Unit, First Department of Propaedeutic Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Karamanakos","sequence":"additional","affiliation":[{"name":"Joint Academic Rheumatology Program, Rheumatology Unit, First Department of Propaedeutic Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexios","family":"Iliopoulos","sequence":"additional","affiliation":[{"name":"Rheumatology Department, 417 Army Shared Fund Hospital NIMTS, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2238-0975","authenticated-orcid":false,"given":"Maria G.","family":"Tektonidou","sequence":"additional","affiliation":[{"name":"Joint Academic Rheumatology Program, Rheumatology Unit, First Department of Propaedeutic Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros P.","family":"Sfikakis","sequence":"additional","affiliation":[{"name":"Joint Academic Rheumatology Program, Rheumatology Unit, First Department of Propaedeutic Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4932-7023","authenticated-orcid":false,"given":"George E.","family":"Fragoulis","sequence":"additional","affiliation":[{"name":"Joint Academic Rheumatology Program, Rheumatology Unit, First Department of Propaedeutic Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75 Str, Athens 11527, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"bibr1-1759720X221122417","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00293-y"},{"key":"bibr2-1759720X221122417","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X20976975"},{"key":"bibr3-1759720X221122417","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-021-05774-9"},{"key":"bibr4-1759720X221122417","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-021-00420-x"},{"key":"bibr5-1759720X221122417","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05065-9"},{"key":"bibr6-1759720X221122417","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215960"},{"key":"bibr7-1759720X221122417","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211998"},{"key":"bibr8-1759720X221122417","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2021-001756"},{"key":"bibr9-1759720X221122417","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"},{"key":"bibr10-1759720X221122417","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207507"},{"key":"bibr11-1759720X221122417","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.102053"},{"key":"bibr12-1759720X221122417","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2012.031"},{"key":"bibr13-1759720X221122417","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"bibr14-1759720X221122417","first-page":"52","volume":"59","author":"Punzi 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