{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:25:50Z","timestamp":1788963950925,"version":"build-2803163510"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009888","name":"Regione Toscana","doi-asserted-by":"publisher","award":["Registro COVASAKI: sorveglianza di casi di Sindrom"],"award-info":[{"award-number":["Registro COVASAKI: sorveglianza di casi di Sindrom"]}],"id":[{"id":"10.13039\/501100009888","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Neurological manifestations related to SARS-CoV-2 infection in adults have been largely reported since the beginning of the pandemic. Subsequent large-scale studies involving children confirmed the occurrence of neurological symptoms associated with SARS-CoV-2 infection also among paediatric patients, especially in the context of paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS). At this regard, we report the challenging case of a 10-month-old baby with PIMS-TS complicated by acute cerebral oedema successfully treated with intravenous immunoglobulins, corticosteroids and anakinra. Our results, combined with the evidence of larger case series suggest that higher inflammatory burden is more frequent in patients with neuro PIMS-TS. As regards neuroimaging, neuroimmune disorders are found to be more common during acute COVID-19, MERS is more frequent during PIMS-TS. Distinct immune mechanisms may underlie these different types of neurological involvement, which are yet to be understood. Further studies are required to better define the physiopathology of neuro PIMS-TS and its possible therapeutical implications.<\/jats:p>","DOI":"10.1177\/1759720x221139627","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T08:04:03Z","timestamp":1670832243000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Neuro-PIMS-TS: a single case report and review of the literature"],"prefix":"10.1177","volume":"14","author":[{"given":"Antonio","family":"Scarcella","sequence":"first","affiliation":[{"name":"Pediatric Residency, Meyer Children\u2019s University Hospital, University of Florence, Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9784-3543","authenticated-orcid":false,"given":"Maria Vincenza","family":"Mastrolia","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Meyer Children\u2019s University Hospital, University of Florence, Viale Gaetano Pieraccini, 24, Firenze 50139, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Marrani","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Meyer Children\u2019s Hospital, Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Maccora","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Meyer Children\u2019s Hospital, Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Pagnini","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Meyer Children\u2019s Hospital, Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5919-4861","authenticated-orcid":false,"given":"Gabriele","family":"Simonini","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Meyer Children\u2019s University Hospital, University of Florence, Firenze, Italy"},{"name":"NEUROFARBA Department, University of Florence, Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"bibr1-1759720X221139627","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.1467"},{"key":"bibr2-1759720X221139627","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-0702"},{"key":"bibr3-1759720X221139627","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31103-X"},{"key":"bibr4-1759720X221139627","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31094-1"},{"key":"bibr5-1759720X221139627","unstructured":"Royal College of Paediatrics and Child Health. 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