{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:41:46Z","timestamp":1790804506910,"version":"4.1.0"},"reference-count":53,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Interstitial lung disease (ILD) is the leading cause of mortality in systemic sclerosis (SSc).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We performed an overview of the diagnostic approaches, follow-up and treatment strategies used in France for the management of SSc-associated ILD (SSc-ILD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design: Structured nationwide online survey.Methods:<\/jats:title>\n                    <jats:p>A structured nationwide online survey was submitted to participants via the French Medical Societies for Internal Medicine and Pneumology, and research groups on SSc-ILD from May 2018 to June 2020. The 79 multiple-choice and 9 open-ended questions covered the screening of ILD at baseline, monitoring of patients with established SSc-ILD and its management. Fourteen optional vignettes exploring different clinical phenotypes of SSc-ILD were submitted to evaluate therapeutic decisions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      All of the 93 participants screened SSc patients for ILD at baseline with 83 (89%) participants relying on a systematic chest computed tomography (CT) scan. Pulmonary function tests (PFT) were prescribed by 87 (94%) participants at baseline and during follow-up. Treatment was started based on abnormal PFT (95%), chest CT scan characteristics (89%), worsening dyspnoea (72%) and drop in SpO\n                      <jats:sub>2<\/jats:sub>\n                      during 6-min walk tests (66%). First-line therapy was cyclophosphamide (CYC) (89%), mycophenolate mofetil (MMF) (83%) and prednisone (73%). Rituximab as second-line immunosuppressive therapy (41%) was preferred to antifibrotic agents (18%), and a median daily prednisone dose of 10\u2009mg (interquartile range, 10\u201315) was prescribed by 73% participants. Extensive SSc-ILD with worsening PFT (95%), regardless of diffusing capacity for carbon monoxide values and skin extension, were more likely to be treated, and CYC was favoured over MMF ( p\u2009&lt;\u20090.01). Extensive SSc-ILD with disease duration of less than 5\u2009years was also a criterium for treatment initiation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This overview of practices in diagnosis, follow-up and treatment of SSc-ILD in France describes real-life management of patients. It highlights heterogeneity in this management and gaps in current strategies that should be addressed to improve and harmonize clinical practices in SSc-ILD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x231159712","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T05:02:46Z","timestamp":1683608566000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Systemic sclerosis associated interstitial lung disease: a survey of current practices in France"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8436-4009","authenticated-orcid":false,"given":"Am\u00e9lie","family":"Nicolas","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology, Centre de R\u00e9f\u00e9rence des Maladies Auto-immunes Syst\u00e9miques Rares du Nord et Nord-Ouest de France (CeRAINO), University Hospital of Lille, Rue Michel Polonovski, H\u00f4pital Huriez, CHU Lille, F-59000 Lille, France"},{"name":"Univ. Lille, U1286 \u2013 INFINITE \u2013 Institute for Translational Research in Inflammation, Lille, France"},{"name":"INSERM, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Leroy","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, University Hospital of Nice, Nice, France"},{"name":"C\u00f4te d\u2019Azur University, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Mouthon","sequence":"additional","affiliation":[{"name":"Reference Centre for Systemic Autoimmune Diseases, Cochin Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurdagul","family":"Uzunhan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, Avicenne Hospital, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Cottin","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, Louis Pradel Hospital, Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arsene","family":"Mekinian","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology, Saint-Antoine Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"Queyrel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology, University Hospital of Nice, Nice, France"},{"name":"C\u00f4te d\u2019Azur University, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Hachulla","sequence":"additional","affiliation":[{"name":"Univ. Lille, U1286 \u2013 INFINITE \u2013 Institute for Translational Research in Inflammation, Lille, France"},{"name":"INSERM, Paris, France"},{"name":"CHU Lille, D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, Centre de R\u00e9f\u00e9rence des Maladies Auto-immunes"},{"name":"Syst\u00e9miques Rares du Nord et Nord-Ouest de France (CeRAINO), Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Gachet","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Gustave Dron Hospital, Tourcoing, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Launay","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology, Centre de R\u00e9f\u00e9rence des Maladies Auto-immunes Syst\u00e9miques Rares du Nord et Nord-Ouest de France (CeRAINO), University Hospital of Lille, Rue Michel Polonovski, H\u00f4pital Huriez, CHU Lille, F-59000 Lille, France"},{"name":"Univ. Lille, U1286 \u2013 INFINITE \u2013 Institute for Translational Research in Inflammation, Lille, France"},{"name":"INSERM, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihal","family":"Martis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology, University Hospital of Nice, Nice, France"},{"name":"C\u00f4te d\u2019Azur University, Nice, France"},{"name":"INSERM U1065 \u2013 Mediterranean Centre for Molecular Medicine, Control of gene expression (COdEX), Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Groupe Orphalung, Groupe Francophone de Recherche sur la Scl\u00e9rodermie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"bibr1-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-010-8198-y"},{"key":"bibr2-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2018.08.005"},{"key":"bibr3-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00005512"},{"key":"bibr4-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000551"},{"key":"bibr5-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.066068"},{"key":"bibr6-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1002\/art.38029"},{"key":"bibr7-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.2147\/OARRR.S226695"},{"key":"bibr8-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30480-1"},{"key":"bibr9-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(19)30144-4"},{"key":"bibr10-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1002\/art.40130"},{"key":"bibr11-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes289"},{"key":"bibr12-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1002\/art.38390"},{"key":"bibr13-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1002\/art.34482"},{"key":"bibr14-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213201"},{"key":"bibr15-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209909"},{"key":"bibr16-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-0980-7"},{"key":"bibr17-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2018.1427064"},{"key":"bibr18-1759720X231159712","first-page":"1064","volume":"35","author":"B\u00e9rezn\u00e9 A","year":"2008","journal-title":"J Rheumatol"},{"key":"bibr19-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000592"},{"key":"bibr20-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1517-z"},{"key":"bibr21-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzg031"},{"key":"bibr22-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.136929"},{"key":"bibr23-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200706-877OC"},{"key":"bibr24-1759720X231159712","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken271"},{"key":"bibr25-1759720X231159712","unstructured":"Hachulla E, Agard C, Allanore Y, et al. 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