{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:06:02Z","timestamp":1787785562507,"version":"build-2784847793"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients with idiopathic inflammatory myopathies (IIMs) are at risk of reduced bone mineral density (BMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To compare the prevalence of reduced BMD between patients with IIMs and controls and to determine its risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This was a single-center case-control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>BMD was assessed by dual-energy X-ray absorptiometry. The prevalence of reduced BMD in IIM patients and age-and sex-matched non-rheumatological controls was compared. The BMD results of female IIM were also compared to age-matched female rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients. Independent factors associated with reduced BMD in IIM patients were identified by multivariate analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 230 patients (IIM: 65, non-rheumatological controls: 65, RA: 50, SLE: 50) were recruited. The mean age of IIM patients was 58.6\u2009\u00b1\u200911.0\u2009years and 76.9% were females. Significantly, more IIM patients had reduced BMD (73.8% versus 43.1%, p\u2009=\u20090.043) and osteoporosis (29.2% versus 13.8%, p\u2009=\u20090.033) than non-rheumatological controls. Multivariate analysis confirmed that IIM was independently associated with reduced BMD (OR: 2.12, p\u2009=\u20090.048, 95% CI: 1.01\u20134.46). The prevalence of reduced BMD was not significantly different between IIM, RA, and SLE patients but the mean hip BMD was the lowest in the IIM group (0.641\u2009\u00b1\u20090.152\u2009g\/cm\n                      <jats:sup>2<\/jats:sup>\n                      versus 0.663\u2009\u00b1\u20090.102g\/cm\n                      <jats:sup>2<\/jats:sup>\n                      in the RA group versus 0.708\u2009\u00b1\u20090.132\u2009g\/cm\n                      <jats:sup>2<\/jats:sup>\n                      in the SLE group, p\u2009=\u20090.035). Lower body mass index and more advanced age were independently associated with lower BMD in IIM patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Reduced BMD was more prevalent in IIM patients than in non-rheumatological controls. Hip BMD was lower in patients with IIMs than RA or SLE. Close monitoring and early treatment are encouraged especially in patients with risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x231181968","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T02:51:20Z","timestamp":1689562280000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Reduced bone mineral density in patients with idiopathic inflammatory myopathies: a case-control study"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1636-5384","authenticated-orcid":false,"given":"Iris Yan Ki","family":"Tang","sequence":"first","affiliation":[{"name":"Division of Rheumatology and Clinical Immunology, Department of Medicine, The University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Luk","sequence":"additional","affiliation":[{"name":"Department of Medicine and Geriatrics, Kwong Wah Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Geriatrics, Kwong Wah Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Medicine and Geriatrics, Kwong Wah Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Lao","sequence":"additional","affiliation":[{"name":"Department of Medicine and Geriatrics, Kwong Wah Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho","family":"So","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong 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