{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:04:03Z","timestamp":1793127843450,"version":"4.5.0"},"reference-count":47,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III (ISCIII), Ministry of Health, Spain, Red de Enfermedades Inflamatorias","award":["RD21\/0002\/0001"],"award-info":[{"award-number":["RD21\/0002\/0001"]}]},{"DOI":"10.13039\/501100008530","name":"Fondo Europeo de Desarrollo Regional","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Switching between therapies is a recommended strategy for psoriatic arthritis (PsA) patients who experience treatment failure; however, studies including real-life data are scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To assess the incidence rate (IR) of switching between biologics and targeted synthetic disease-modifying anti-rheumatic drugs (b\/tsDMARDs) due to inefficacy in PsA, and to compare the risk of switching due to inefficacy across different b\/tsDMARDs groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A longitudinal retrospective study, spanning from 2007 to 2022, was conducted on patients with PsA treated with b\/tsDMARDs at an outpatient rheumatology clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The primary outcome was switching between b\/tsDMARDs due to inefficacy. The independent variable was the exposure to b\/tsDMARDs during follow-up. As covariates, clinical, treatment-related, and sociodemographic variables were considered. Survival techniques were run to estimate the IR of switching due to inefficacy per 100 patients*year and confidence interval at 95% (95% CI). Cox multivariate regression analyses were run to assess the risk of b\/tsDMARDs switching due to inefficacy, expressed as hazard ratio (HR) and 95% CI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In all, 141 patients were included, with 893.09 patients*year follow-ups. 52.48% of them were females in their fifties. In total, 262 courses of treatment were recorded. During the study period, 56 patients presented 121 switches and 103 related to inefficacy (IR: 11.53 (9.51\u201313.98)). Tumor necrosis factor-alpha inhibitors (TNFi) showed the lowest IR. In the bivariate analysis, all b\/tsDMARDs had more risk of switching compared to TNFi (HR: anti-lL-17 vs TNFi: 2.26 (1.17\u20134.36); others vs TNFi: 3.21 (1.59\u20136.45)); however, this statistical significance was no longer present in the multivariate analysis once adjustments were made for the covariates. Still, the final model achieved statistical significance in the following variables: gender, clinical symptoms, prescription year, therapy courses, glucocorticoids, and sulfasalazine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this study, we did not find differences in the rate of switching due to inefficacy among different groups of b\/tsDMARDs. Other concomitant treatments, sociodemographic, and clinical variables were identified as risk factors for switching due to inefficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x241273083","type":"journal-article","created":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T07:23:45Z","timestamp":1725089025000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Switching related to inefficacy in biologics and targeted synthetic therapies for psoriatic arthritis: a comparative real-life study"],"prefix":"10.1177","volume":"16","author":[{"given":"Dalifer","family":"Freites-Nu\u00f1ez","sequence":"first","affiliation":[{"name":"Rheumatology Department, Hospital Cl\u00ednico San Carlos, IdISSC, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7142-0545","authenticated-orcid":false,"given":"Leticia","family":"Leon","sequence":"additional","affiliation":[{"name":"Leon Musculoskeletal Pathology Group, Rheumatology Department, IdISSC, Hospital Cl\u00ednico San Carlos, Madrid, Spain"},{"name":"Faculty of Health Sciences - HM Hospitals, University Camilo Jos\u00e9 Cela, Calle Mart\u00edn Lagos, s\/n. Madrid 28040, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Toledano","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Cl\u00ednico San Carlos, IdISSC, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Candelas","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Cl\u00ednico San Carlos, IdISSC, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Martinez","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Cl\u00ednico San Carlos, IdISSC, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Rodriguez-Laguna","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Cl\u00ednico San Carlos, IdISSC, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rubio","sequence":"additional","affiliation":[{"name":"Medicine Department, Universidad Complutense de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6126-8786","authenticated-orcid":false,"given":"Benjamin","family":"Fernandez-Gutierrez","sequence":"additional","affiliation":[{"name":"Medicine Department, Universidad Complutense de Madrid, Madrid, Spain"},{"name":"Musculoskeletal Pathology Group, Rheumatology Department, IdISSC, Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Abasolo","sequence":"additional","affiliation":[{"name":"Musculoskeletal Pathology Group, Rheumatology Department, IdISSC, Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,31]]},"reference":[{"key":"bibr1-1759720X241273083","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.17-1-65"},{"key":"bibr2-1759720X241273083","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1505557"},{"key":"bibr3-1759720X241273083","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2015.07.001"},{"key":"bibr4-1759720X241273083","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30830-4"},{"key":"bibr5-1759720X241273083","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3579(94)80024-3"},{"key":"bibr6-1759720X241273083","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-021-00349-1"},{"key":"bibr7-1759720X241273083","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205207"},{"key":"bibr8-1759720X241273083","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217163"},{"key":"bibr9-1759720X241273083","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3899\/jrheum.211043","volume":"49","author":"Coates LC","year":"2022","journal-title":"J Rheumatol"},{"key":"bibr10-1759720X241273083","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-022-00798-0"},{"key":"bibr11-1759720X241273083","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140876"},{"key":"bibr12-1759720X241273083","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102902"},{"key":"bibr13-1759720X241273083","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2021-002074"},{"key":"bibr14-1759720X241273083","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.708168"},{"key":"bibr15-1759720X241273083","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.02.001"},{"key":"bibr16-1759720X241273083","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.03.008"},{"key":"bibr17-1759720X241273083","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"},{"key":"bibr18-1759720X241273083","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181577654"},{"key":"bibr19-1759720X241273083","unstructured":"Freeman DH. 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