{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:44:12Z","timestamp":1777877052706,"version":"3.51.4"},"reference-count":55,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Randomized clinical trials have demonstrated the efficacy of secukinumab (SECU) in reducing disease activity in psoriatic arthritis (PsA), while real-world studies prove a broader perspective on SECU\u2019s usefulness in everyday clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To assess the effectiveness of SECU by evaluating drug survival and identifying potential predictors of clinical response and treatment discontinuation in patients with moderate-to-severe PsA, using real-world data from the Italian Group for the Study of Early Arthritis (GISEA) registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This longitudinal retrospective study included PsA patients treated with SECU, spanning from May 2016 to November 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data from 1045 PsA patients, including 783 with peripheral-only PsA (perPsA) and 262 with peripheral and axial involvement (mixed PsA) were analyzed. Drug survival was estimated by Kaplan\u2013Meier analysis. Clinical outcomes, including Disease Activity Index for Psoriatic Arthritis (DAPSA), Psoriasis Area Severity Index (PASI), Ankylosing Spondylitis Disease Activity Score (ASDAS, C-Reactive Protein (CRP)-based), and Visual Analogue Scale (VAS) measures, were evaluated at baseline and at 6, 12, and 24\u2009months. Adjusted hazard ratios (aHRs) for discontinuing SECU were determined using multivariate Cox regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>SECU survival at 24\u2009months was 63.24%, significantly higher in mixed PsA compared to perPsA ( p\u2009=\u20090.036). In the overall PsA population, DAPSA scores decreased significantly at 6\u2009months, and further at 24\u2009months (all p\u2009&lt;\u20090.0001). In mixed PsA, ASDAS-CRP scores were significantly reduced at 6\u2009months and remained stable through 24\u2009months (all p\u2009&lt;\u20090.0001). VAS pain scores also improved already at 6\u2009months and continued to improve at 24\u2009months (all p\u2009&lt;\u20090.0001). Higher age (aHR\u2009=\u20090.98, 95% confidence interval (CI): 0.96\u20130.99, p\u2009=\u20090.007) and lower baseline DAPSA scores (aHR\u2009=\u20091.02, 95% CI: 1.01\u20131.03, p\u2009=\u20090.014) were associated with greater persistence of SECU treatment. SECU was well tolerated, with no serious adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>SECU showed sustained clinical improvements in both peripheral and axial involvement of PsA patients over 24\u2009months, with higher persistence observed in mixed PsA patients. Our findings highlight the favorable clinical and safety profile of SECU in real world.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x251315138","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T05:24:47Z","timestamp":1738301087000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and retention rate of secukinumab in psoriatic arthritis across different clinical phenotypes: insights from the Italian GISEA Registry"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4524-9566","authenticated-orcid":false,"given":"Giuseppe","family":"Lopalco","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, Piazza G. Cesare 11, Bari 70124, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Morrone","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola","family":"Atzeni","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Experimental and Internal Medicine, University of Messina, Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Bazzani","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology Unit, ASST Spedali Civili of Brescia, Brescia, Lombardia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco Paolo","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Health Prevention Department, Local Health Authority of Brindisi, Brindisi, Puglia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco Paolo","family":"Cantatore","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, University of Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Caporali","sequence":"additional","affiliation":[{"name":"Dipartimento di Reumatologia e Scienze Mediche, ASST PINI-CTO and Dipartimento di Scienze Cliniche e di Comunit\u00e0, Universit\u00e0 di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Carletto","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, University of Verona, Verona, Veneto, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Cauli","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Public Health, University of Cagliari and Rheumatology Unit, Azienda Ospedaliero Universitaria di Cagliari, Monserrato, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Sole","family":"Chimenti","sequence":"additional","affiliation":[{"name":"Rheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, Roma, Lazio, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Colella","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, ASL Taranto Valle d\u2019Itria Hospital, Martina Franca, Taranto, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Conti","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Addolorata","family":"Corrado","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, University of Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ennio Giulio","family":"Favalli","sequence":"additional","affiliation":[{"name":"Dipartimento di Reumatologia e Scienze Mediche, ASST PINI-CTO and Dipartimento di Scienze Cliniche e di Comunit\u00e0, Universit\u00e0 di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Floris","sequence":"additional","affiliation":[{"name":"Department of Medical Science and Public Health, University of Cagliari and Rheumatology Unit, Azienda Ospedaliero Universitaria di Cagliari, Monserrato, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Fornaro","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Foti","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, A.O.U. Policlinico S. Marco, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Foti","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, A.O.U. Policlinico S. Marco, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Fracassi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, University of Verona, Verona, Veneto, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Frediani","sequence":"additional","affiliation":[{"name":"U.O.C. Reumatologia, Azienda Ospedaliero Universitaria Senese, Siena, Toscana, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Gentileschi","sequence":"additional","affiliation":[{"name":"U.O.C. Reumatologia, Azienda Ospedaliero Universitaria Senese, Siena, Toscana, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Gorla","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology Unit, ASST Spedali Civili of Brescia, Brescia, Lombardia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Gremese","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Praino","sequence":"additional","affiliation":[{"name":"U.O.S. 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