{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:53:32Z","timestamp":1790776412292,"version":"4.1.0"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The effectiveness of anti-tumour necrosis factor (TNF) therapy in spondyloarthritis is traditionally associated with factors such as age, obesity and disease subtypes. However, less-explored aspects, such as mental health, socioeconomic status and work type may also play a crucial role in determining inflammatory activity and therapeutic response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To identify the most significant factors explaining inflammatory activity levels in patients treated with anti-TNF therapy and to develop an interpretable machine-learning model with good performance and minimal overfitting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This is an observational, cross-sectional and multicentre study with socio-demographical and clinical data extracted from the Registry of Spondyloarthritis of Spanish Rheumatology (REGISPONSER) and Ibero-American Registry of Spondyloarthropathies (RESPONDIA) registries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We selected patients receiving anti-TNF therapy and applied five feature selection methods to identify key factors. We evaluated these factors using 182 machine learning models, and, finally, we selected a decision tree model that offered comparable performance with reduced overfitting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Activity levels appear strongly influenced by quality-of-life indicators, particularly the SF-12 physical and mental components and Ankylosing Spondylitis Quality of Life scores. While factors such as age, weight, years of treatment and age at diagnosis have relevance, they are not necessary to obtain a pruned tree with similar cross-validated mean accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Recognizing the central role of physical and mental well-being in managing disease activity can lead to better therapeutic strategies for chronic disease management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x251332224","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:18:59Z","timestamp":1747268339000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Inflammatory activity levels on patients with anti-TNF therapy: most important factors and a decision tree model based on REGISPONSER and RESPONDIA registries"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7315-6274","authenticated-orcid":false,"given":"David","family":"Castro Corredor","sequence":"first","affiliation":[{"name":"Rheumatology Department, Hospital General Universitario Ciudad Real, Obispo Rafael Torija Street, Ciudad Real 13005, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis \u00c1ngel","family":"Calvo Pascual","sequence":"additional","affiliation":[{"name":"Department of Quantitative Methods, ICADE, Universidad Pontificia de Comillas, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Collantes-Est\u00e9vez","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Cordoba, Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC), C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2309-5837","authenticated-orcid":false,"given":"Clementina","family":"L\u00f3pez-Medina","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Reina Sofia University Hospital, C\u00f3rdoba, Spain"},{"name":"Department of Medical and Surgical Sciences, University of Cordoba, Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC), C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00382"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2022.152078"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.2312"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0291891"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmed.2023.100125"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780341003"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem084"},{"key":"e_1_3_4_9_2","article-title":"Ibero-American Spondylarthritis Registry (RESPONDIA): what is, how came about, who we are and what we do","volume":"4","author":"Vazquez-Mellado J","year":"2008","unstructured":"Vazquez-Mellado J, Font Ugalde P, Mu\u00f1oz Gomariz E, et al. Ibero-American Spondylarthritis Registry (RESPONDIA): what is, how came about, who we are and what we do. Reumatol Cl\u00edn 2008; 4: S17\u2013S22.","journal-title":"Reumatol Cl\u00edn"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040296"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2013.12.006"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138594"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2024-004218"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae549"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab242"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez657"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23465"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25048"},{"issue":"8","key":"e_1_3_4_19_2","first-page":"744","article-title":"Gender-specific differences in the diagnosis and treatment of inflammatory rheumatic diseases","volume":"64","author":"Albrecht K","year":"2023","unstructured":"Albrecht K, Strangfeld A. Gender-specific differences in the diagnosis and treatment of inflammatory rheumatic diseases. Inn Med (Heidelb) 2023; 64(8): 744\u2013751.","journal-title":"Inn Med (Heidelb)"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0279076"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-023-05455-7"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket433"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.38140"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X221111611"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283620e1d"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2021.12.007"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75352-7"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-021-02647-z"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223296"}],"container-title":["Therapeutic Advances in Musculoskeletal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1759720X251332224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1759720X251332224","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1759720X251332224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:40:04Z","timestamp":1777588804000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1759720X251332224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,14]]},"references-count":28,"alternative-id":["10.1177\/1759720X251332224"],"URL":"https:\/\/doi.org\/10.1177\/1759720x251332224","relation":{},"ISSN":["1759-720X","1759-7218"],"issn-type":[{"value":"1759-720X","type":"print"},{"value":"1759-7218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,14]]},"article-number":"1759720X251332224"}}