{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T21:49:00Z","timestamp":1784929740239,"version":"3.55.0"},"reference-count":39,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The neutrophil-to-lymphocyte ratio (NLR) is a potential surrogate marker for disease activity in many rheumatic diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To study the correlation between NLR and disease activity of systemic lupus erythematosus (SLE) using the SLE disease activity score (SLE-DAS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective, cross-sectional.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Consecutive adult patients who fulfilled the American College of Rheumatology (ACR) or Systemic Lupus International Collaboration Clinic (SLICC) criteria for SLE were recruited between March 2023 and February 2024. SLE activity was assessed by physicians\u2019 global assessment (PGA), SLE-DAS, and SLE disease activity index-2000 (SLEDAI-2K). The calculated NLR was correlated with disease activity indices and serological parameters (anti-dsDNA, C3\/4) by Spearman\u2019s rank correlation. Patients were stratified into SLE-DAS remission, mild, and moderate\/severe disease activity, and a comparison of the NLR was performed among these subgroups by one-way ANOVA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 420 SLE patients were studied (93.1% women, age 31.6\u2009\u00b1\u200913.1\u2009years, SLE duration 15.7\u2009\u00b1\u20098.1\u2009years). Moderate\/severe, mild disease activity and SLE-DAS remission were present in 70 (16.7%), 65 (15.5%), and 285 (67.9%) patients, respectively. SLE-DAS correlated significantly with SLEDAI-2K (rho 0.90;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and PGA (rho 0.60;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The mean NLR of all patients was 3.54\u2009\u00b1\u20094.0 and NLR correlated significantly with SLE-DAS (rho 0.17;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The NLR was significantly higher in patients with active disease in the SLE-DAS renal domain than those in remission (5.17\u2009\u00b1\u20097.11 vs 3.22\u2009\u00b1\u20093.19;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.03). The NLR in patients with moderate\/severe SLE-DAS activity (5.25\u2009\u00b1\u20096.89) was significantly higher than those with mild activity (3.12\u2009\u00b1\u20092.26;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.01) or remission (3.22\u2009\u00b1\u20093.19;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.01). ROC analysis showed that an NLR cut-off of 3.11 showed a sensitivity of 55.6% and specificity of 68.7% in detecting moderate\/severe SLE-DAS activity (area under the curve 0.67 (0.6\u20130.7);\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The NLR is a convenient marker that correlates significantly with disease activity in SLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x251347272","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T06:34:13Z","timestamp":1750314853000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The neutrophil-to-lymphocyte ratio as a surrogate marker for disease activity in systemic lupus erythematosus: a correlation study using the SLE-DAS"],"prefix":"10.1177","volume":"17","author":[{"given":"Mandy Ming Yan","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fung","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pok Oi Hospital, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3696-1228","authenticated-orcid":false,"given":"Chi Chiu","family":"Mok","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00398-2"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-023-00925-5"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211663"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/638413"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000000477"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203320950822"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtauto.2022.100159"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-023-01273-2"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007546"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-024-01689-z"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.25259\/JNRP-2022-4-21"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000038692"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1336456"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214502"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab895"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead132"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2024-eular.2829"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2018.07.008"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.04.006"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.2478\/rir-2023-0029"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-023-03704-z"},{"issue":"2","key":"e_1_3_4_23_2","first-page":"1547","article-title":"Predictive value of the neutrophil-to-lymphocyte ratio and hemoglobin insystemic lupus erythematosus","volume":"16","author":"Yu H","year":"2018","unstructured":"Yu H, Jiang L, Yao L, et al. 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