{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:12:13Z","timestamp":1782519133572,"version":"3.54.5"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Hormonal changes in menopause might interact with the presentation of underlying autoimmune diseases, such as systemic sclerosis (SSc).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Our study aimed to evaluate the association of (1) current menopausal status, (2) early menopause, and (3) disease onset during fertile or post-menopausal age on SSc clinical phenotype in a large SSc cohort from the Italian Systemic sclerosis Progression INvestiGation (SPRING-SIR) registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Female SSc patients from the SPRING-SIR registry, fulfilling the American College of Rheumatology (ACR)\/European Alliance of Associations for Rheumatology (EULAR) 2013 classification criteria, with data on SSc disease onset, menopausal status, and menopausal age, were eligible. SSc onset was categorized as pre-menopausal if SSc onset happened &gt;1\u2009year before menopause or as post-menopausal onset if it occurred &gt;1\u2009year after menopause. An early menopause was defined by a menopausal age &lt;45\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Descriptive statistics and regression models were built to test the association between current menopausal status, pre-menopausal disease onset, and early menopause with SSc-related features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At baseline, 1157\/1538 (75%) patients were in menopause, 632 (50.4%) had a pre-menopausal SSc onset, and 130 (14.4%) reported an early menopause. Post-menopausal patients had more frequent limited cutaneous SSc, anti-centromere antibody positivity, interstitial lung disease, and gastrointestinal manifestations. Pre-menopausal onset cases showed more frequent diffuse cutaneous involvement and peripheral vasculopathy. Patients with early menopause had more frequent peripheral vasculopathy and interstitial lung disease, being early menopause an independent risk factor for digital ulcers and lower diffusing capacity of the lung for carbon monoxide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Current post-menopausal status and early menopause may impact SSc presentation, being associated with vascular and gastrointestinal manifestations. Menopausal status and age should therefore be thoroughly addressed, aiming at better disease management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x251354898","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T07:18:06Z","timestamp":1752477486000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Menopause in systemic sclerosis: the impact on clinical presentation in a multicenter cross-sectional analysis from the National Registry of the Italian Society for Rheumatology (SPRING-SIR)"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6784-2235","authenticated-orcid":false,"given":"Martina","family":"Orlandi","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilia","family":"Giuggioli","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clodoveo","family":"Ferri","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy"},{"name":"Rheumatology Clinic \u201cMadonna dello Scoglio\u201d Cotronei, Crotone, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"De Angelis","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Riccieri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7479-4462","authenticated-orcid":false,"given":"Fabio","family":"Cacciapaglia","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Precision and Regenerative Medicine-Ionian Area, University of Bari \u201cAldo Moro,\u201d Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Laura","family":"Bosello","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli- IRCCS \u2013 Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Codullo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, Universit\u00e0 di Pavia, Pavia, Italy"},{"name":"Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Bajocchi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, S. Maria Hospital-USL, IRCCS Institute, Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Dagna","sequence":"additional","affiliation":[{"name":"Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, and Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Campochiaro","sequence":"additional","affiliation":[{"name":"Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, and Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"De Luca","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, S. Maria Hospital-USL, IRCCS Institute, Reggio Emilia, Italy"},{"name":"Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, and Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5042-1282","authenticated-orcid":false,"given":"Giovanni","family":"Zanframundo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Therapeutics, Universit\u00e0 di Pavia, Pavia, Italy"},{"name":"Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Foti","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, AOU Policlinico San Marco, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Cuomo","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine \u2013 University of Campania \u2013 Luigi Vanvitelli University, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alarico","family":"Ariani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Internal Medicine and Rheumatology, Azienda Ospedaliero Universitaria di Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Rosato","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Girelli","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rheumatology Unit, Ospedale GB Morgagni\u2013L Pierantoni, Forl\u00ec, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Zanatta","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, AOU Policlinico San Marco, Catania, Italy"},{"name":"Department of Rheumatology, University of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Cavazzana","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy"},{"name":"Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ingegnoli","sequence":"additional","affiliation":[{"name":"Division of Clinical Rheumatology, ASST Pini, Department of Clinical Sciences &amp; Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, Research Center for Environmental Health, Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"De Santis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Murdaca","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Genoa and Allergology and Clinical Immunology Unit, Ospedale San Bartolomeo Sarzana, Sarzana, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Abignano","sequence":"additional","affiliation":[{"name":"Department of Health Science, University of Basilicata, Potenza, Italy Rheumatology Unit, San Carlo Hospital, Potenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Petitti","sequence":"additional","affiliation":[{"name":"Rheumatology Unit ASO S. Crotea e Carle Hospital, Cuneo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Della Rossa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Caminiti","sequence":"additional","affiliation":[{"name":"Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Iuliano","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, San Camillo\u2013Forlanini Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Ciano","sequence":"additional","affiliation":[{"name":"Local Health Department, Hospital of Ariano Irpino, Ariano Irpino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Beretta","sequence":"additional","affiliation":[{"name":"Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca\u2019 Granda, Ospedale Maggiore Policlinico di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Bagnato","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ennio","family":"Lubrano","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University of Molise, Campobasso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilenia","family":"De Andres","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Azienda Ospedaliera di Rilievo Nazionale ed Alta Specializzazione Garibaldi, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Giollo","sequence":"additional","affiliation":[{"name":"Rheumatology Section, Department of Medicine, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Saracco","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Mauriziano-Umberto I Hospital, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Agnes","sequence":"additional","affiliation":[{"name":"Division of Rehabilitation, Department of Medicine, Torino, ASL TO5, Carmagnola (TO), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Cipolletta","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Lumetti","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Spinella","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Magnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Visalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Iandoli","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, S. Maria Hospital-USL, IRCCS Institute, Reggio Emilia, Italy"},{"name":"Department of Precision Medicine \u2013 University of Campania \u2013 Luigi Vanvitelli University, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"Gigante","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Rheumatology Department, IRCCS Ospedale Galeazzi, Sant\u2019Ambrogio, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Pigatto","sequence":"additional","affiliation":[{"name":"UOC Medicina Generale, Ospedale San Bassiano, Bassano del Grappa (VI), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Lazzaroni","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy"},{"name":"Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Franceschini","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy"},{"name":"Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Generali","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan and Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianna","family":"Mennillo","sequence":"additional","affiliation":[{"name":"Department of Health Science, University of Basilicata, Potenza, Italy Rheumatology Unit, San Carlo Hospital, Potenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Barsotti","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University of Pisa, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppa","family":"Pagano Mariano","sequence":"additional","affiliation":[{"name":"Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Furini","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna, Ferrara, Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licia","family":"Vultaggio","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna, Ferrara, Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Parisi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Azienda Ospedaliera Universitaria Citt\u00e0 Della Salute e della Scienza di Torino, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Lisa","family":"Peroni","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Azienda Ospedaliera Universitaria Citt\u00e0 Della Salute e della Scienza di Torino, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerolamo","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medical Specialities, Local Health Trust 3, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Fusaro","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Azienda Ospedaliera Universitaria Citt\u00e0 Della Salute e della Scienza di Torino, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Domenico","family":"Sebastiani","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, San Camillo\u2013Forlanini Hospital, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Govoni","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna, Ferrara, Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7442-1110","authenticated-orcid":false,"given":"Salvatore","family":"D\u2019Angelo","sequence":"additional","affiliation":[{"name":"Department of Health Science, University of Basilicata, Potenza, Italy Rheumatology Unit, San Carlo Hospital, Potenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Cozzi","sequence":"additional","affiliation":[{"name":"UOC Medicina Generale, Ospedale San Bassiano, Bassano del Grappa (VI), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0548-4983","authenticated-orcid":false,"given":"Andrea","family":"Doria","sequence":"additional","affiliation":[{"name":"Rheumatology Department, IRCCS Ospedale Galeazzi, Sant\u2019Ambrogio, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Salvarani","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, S. Maria Hospital-USL, IRCCS Institute, Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0474-5344","authenticated-orcid":false,"given":"Florenzo","family":"Iannone","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Precision and Regenerative Medicine-Ionian Area, University of Bari \u201cAldo Moro,\u201d Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Guiducci","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bellando-Randone","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Matucci-Cerinic","sequence":"additional","affiliation":[{"name":"Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, and Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2813-2083","authenticated-orcid":false,"given":"Cosimo","family":"Bruni","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital Zurich, University of Zurich, R\u00e4mistrasse 100, 8091, Zurich, Switzerland"},{"name":"Department of Experimental and Clinical Medicine, University of Florence, Via delle Oblate 4, Florence 50139, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1386.043"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0503-4"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2019.07.007"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.11.006"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102494"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-021-08910-0"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.210794"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac660"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(22)00193-X"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-021-05997-w"},{"key":"e_1_3_4_12_2","article-title":"Sex and time to diagnosis in systemic sclerosis: an updated analysis of 1,129 patients from the Canadian scleroderma research group registry","volume":"32","author":"Delisle VC","year":"2014","unstructured":"Delisle VC, Hudson M, Baron M, et al. Sex and time to diagnosis in systemic sclerosis: an updated analysis of 1,129 patients from the Canadian scleroderma research group registry. Clin Exp Rheumatol 2014; 32(6 Suppl 86): S-10-4.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar4587"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90576-6"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02208027"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2004.08.006"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2023-003380"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04221.x"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/03009740600844498"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead497"},{"key":"e_1_3_4_21_2","first-page":"50","article-title":"Development of systemic sclerosis in transgender females: a case series and review of the literature","volume":"36","author":"Campochiaro C","year":"2018","unstructured":"Campochiaro C, Host LV, Ong VH, et al. Development of systemic sclerosis in transgender females: a case series and review of the literature. Clin Exp Rheumatol 2018; 36(Suppl 113: 4): 50\u201352.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098"},{"key":"e_1_3_4_23_2","first-page":"40","article-title":"Systemic sclerosis Progression INvestiGation (SPRING) Italian registry: demographic and clinico-serological features of the scleroderma spectrum","volume":"38","author":"Ferri C","year":"2020","unstructured":"Ferri C, Giuggioli D, Guiducci S, et al. Systemic sclerosis Progression INvestiGation (SPRING) Italian registry: demographic and clinico-serological features of the scleroderma spectrum. Clin Exp Rheumatol 2020; 38(Suppl 125: 3): 40\u201347.","journal-title":"Clin Exp Rheumatol"},{"issue":"2","key":"e_1_3_4_24_2","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"LeRoy EC","year":"1988","unstructured":"LeRoy EC, Black C, Fleischmajer R, et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 1988; 15(2): 202\u2013205.","journal-title":"J Rheumatol"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2024.07.040"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209768"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2009.08.003"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05522-5"},{"key":"e_1_3_4_31_2","unstructured":"Ministero della salute https:\/\/www.salute.gov.it\/portale\/donna\/dettaglioContenutiDonna.jsp?lingua=italianoid=4485area=Salute%20donnamenu=prevenzione; https:\/\/theramex.it\/wp-content\/uploads\/2018\/11\/slider-numeri-e-fatti-menopausa-3.jpg (2022 accessed 4 June 2024)."},{"key":"e_1_3_4_32_2","first-page":"375","article-title":"Pulmonary arterial hypertension incidence in patients with systemic sclerosis treated with Bosentan for digital ulcers: evidence from the SPRING-SIR Registry","volume":"52","author":"Cacciapaglia F","year":"2025","unstructured":"Cacciapaglia F, De Angelis R, Ferri C, et al. Pulmonary arterial hypertension incidence in patients with systemic sclerosis treated with Bosentan for digital ulcers: evidence from the SPRING-SIR Registry. J Rheumatol 2025; 52: 375\u2013382.","journal-title":"J Rheumatol"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq321"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05296.x"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(00)80060-9"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(98)70137-1"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00708-5"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-12-199412150-00005"}],"container-title":["Therapeutic Advances in Musculoskeletal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1759720X251354898","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1759720X251354898","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1759720X251354898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:40:08Z","timestamp":1777588808000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1759720X251354898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":37,"alternative-id":["10.1177\/1759720X251354898"],"URL":"https:\/\/doi.org\/10.1177\/1759720x251354898","relation":{},"ISSN":["1759-720X","1759-7218"],"issn-type":[{"value":"1759-720X","type":"print"},{"value":"1759-7218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"article-number":"1759720X251354898"}}