{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:44:25Z","timestamp":1777877065125,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Chronic non-bacterial osteomyelitis (CNO) is a rare autoinflammatory disease characterized by bone pain and sterile bone inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed at describing clinical presentation, laboratory and imaging features, densitometric assessment, and therapeutic approaches in a monocentric CNO cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Monocentric retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients were included in the Chronic non-bActerial osteoMyELitis: A mOnocentric regisTry (CAMELOT) in case of (i) clinical diagnosis of CNO, (ii) the fulfilment of diagnostic\/classification criteria, (iii) at least one medical visit at our institution between June 2004 and June 2024, and (iv) a follow-up of at least 3\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fifty-one patients were included in the CAMELOT (mean age at onset 11.14\u2009years, 68.6% females). A total of 39.2% of patients presented an autoimmune comorbidity. Bone pain was invariably present; joint involvement was demonstrated in 9.6% of patients. Most subjects (86.3%) had multifocal disease: the median number of bony lesions per patient was 4. Lumbar spine dual-energy X-ray absorptiometry (DXA) was performed in 14 patients (27.4%), showing a reduced bone mineral density (BMD) (\u22121.14\u2009\u00b1\u20091.21\n                      <jats:italic toggle=\"yes\">Z<\/jats:italic>\n                      -score). A total of 18 patients (35.3%) experienced a fracture on a bony lesional site; 14 patients (27.4%) presented vertebral fractures (VFs) at onset, with multiple VFs in 5 cases (35.7%). BMD\n                      <jats:italic toggle=\"yes\">Z<\/jats:italic>\n                      -scores (\u22121.7 vs \u22120.5) were lower in patients with VFs, with a higher rate of \u201clow BMD for age\u201d (37.5% vs 16.7%) compared to patients without VFs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The high prevalence of VF observed in the CAMELOT cohort highlights the importance of enlisting CNO in the diagnostic approach to pediatric patients presenting with VF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x251375183","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T10:01:05Z","timestamp":1760436065000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Vertebral fractures and bone health in patients with chronic non-bacterial osteomyelitis at disease onset: insights from the monocentric CAMELOT cohort"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3787-9632","authenticated-orcid":false,"given":"Cecilia Beatrice","family":"Chighizola","sequence":"first","affiliation":[{"name":"Unit of Pediatric Clinical Rheumatology, ASST G. Pini\u2013CTO, Department of Clinical Sciences and Community Health, University of Milan, Piazza Cardinal Ferrari 1, Milan 20122, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Di Taranto","sequence":"additional","affiliation":[{"name":"Unit of Bone Diseases, ASST G. Pini\u2013CTO, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Amati","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Clinical Rheumatology, ASST G. Pini\u2013CTO, Milan, Italy"},{"name":"Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, Milan, Italy"},{"name":"Unit of Bone Diseases, ASST Gaetano Pini\u2013CTO, Milan, Italy"},{"name":"Unit of Clinical Rheumatology, ASST Gaetano Pini\u2013CTO, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debora","family":"Pireddu","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Clinical Rheumatology, ASST G. Pini\u2013CTO, Milan, Italy"},{"name":"Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, Milan, Italy"},{"name":"Unit of Bone Diseases, ASST Gaetano Pini\u2013CTO, Milan, Italy"},{"name":"Unit of Clinical Rheumatology, ASST Gaetano Pini\u2013CTO, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Costi","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Clinical Rheumatology, ASST G. Pini\u2013CTO, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Baldo","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Clinical Rheumatology, ASST G. Pini\u2013CTO, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Crotti","sequence":"additional","affiliation":[{"name":"Unit of Bone Diseases, ASST G. 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