{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:44:27Z","timestamp":1777877067418,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["The Health and Labour Sciences Research Grants for"],"award-info":[{"award-number":["The Health and Labour Sciences Research Grants for"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cartilage damage in rheumatoid arthritis (RA) is commonly evaluated by joint space narrowing (JSN) on conventional radiograph (CR). Cross-sectional studies suggest that ultrasound (US) can directly assess finger-joint cartilage damage; however, whether it can sufficiently evaluate cartilage changes over time remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to investigate temporal changes in cartilage damage in patients with RA using US.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A single-center, retrospective observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Fifty-three patients with RA underwent US scans of finger joints and CR of both hands at baseline and 1\u2009year later. Cartilage thickness was measured at the bilateral second to fifth metacarpophalangeal and proximal interphalangeal joints, and cartilage damage was semiquantitatively scored using recorded US images. JSN was scored on CR using the van der Heijde-modified Sharp method. Patients were grouped by disease activity over 1\u2009year, assessed by Disease Activity Score of 28 joints with C-reactive protein. Continuous variables were analyzed using the Mann\u2013Whitney\n                      <jats:italic toggle=\"yes\">U<\/jats:italic>\n                      or Wilcoxon signed-rank test. Correlations were assessed using Spearman\u2019s rank correlation coefficients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Median patient age and disease duration were 68 and 6.3\u2009years, respectively. Baseline total cartilage thicknesses of 16 joints ranged from 3.1 to 9.1\u2009mm (median, 6.5\u2009mm). Total semiquantitative scores were 0\u201322 (median, 5). Cartilage thickness (rho, \u22120.63;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and semiquantitative (rho, 0.67;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) scores were significantly correlated with JSN scores. Patients with sustained moderate-to-high disease activity showed greater cartilage thickness reduction (median, \u22126.2%) than others (median, \u22121.2%;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.004), although semiquantitative (21.6% vs 16.7%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.74) and JSN (0% vs 0%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.68) scores remained unchanged. The two groups differed significantly in the amount of change (\u22120.4 vs \u22120.1\u2009mm,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>US detected cartilage damage progression in RA over 1\u2009year, supporting its usefulness for longitudinal assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x251414604","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:50:52Z","timestamp":1769154652000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound evaluation of finger joint cartilage damage progression in patients with rheumatoid arthritis"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4173-0651","authenticated-orcid":false,"given":"Takehisa","family":"Ogura","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Toho University, 2-22-36 Ohashi, Meguroku, Tokyo 153-8515, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2114-9190","authenticated-orcid":false,"given":"Chihiro","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Toho University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Hirata","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Toho University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuto","family":"Minegishi","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Toho University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Toho University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayaka","family":"Takenaka","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Toho University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaharu","family":"Katagiri","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Toho University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuto","family":"Takakura","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Toho University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reina","family":"Maezawa","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Toho University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4330-5782","authenticated-orcid":false,"given":"Hideto","family":"Kameda","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Toho University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-203158"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780140605"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21207"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq437"},{"key":"e_1_3_4_6_2","article-title":"Optimal use of MRI in clinical trials, clinical care and clinical registries of patients with rheumatoid arthritis","volume":"32","author":"\u00d8stergaard M","year":"2014","unstructured":"\u00d8stergaard M, M\u00f8ller-Bisgaard S. Optimal use of MRI in clinical trials, clinical care and clinical registries of patients with rheumatoid arthritis. Clin Exp Rheumatol 2014; 32 (Suppl. 85): S-17\u2013S-22.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar4202"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.161433"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205585"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.165.2.7618560"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2021.02.010"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2025.102072"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-023-00286-2"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138461"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92442-2"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.054205"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24101"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1245386"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-014-0437-5"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez153"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcm.2016.02.012"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.10.015"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5466"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.24424"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key443"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab472"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-018-0751-8"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbr.2016.03.007"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206289"},{"key":"e_1_3_4_33_2","article-title":"The reliability of ultrasound in the assessment of hyaline cartilage in rheumatoid arthritis and healthy metacarpal heads","volume":"43","author":"Cipolletta E","year":"2022","unstructured":"Cipolletta E, Filippucci E, Di Matteo A, et al. The reliability of ultrasound in the assessment of hyaline cartilage in rheumatoid arthritis and healthy metacarpal heads. Ultraschall Med 2022; 43: e65\u2013e72.","journal-title":"Ultraschall Med"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.105117"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/9kzptz"}],"container-title":["Therapeutic Advances in Musculoskeletal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1759720X251414604","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1759720X251414604","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1759720X251414604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:40:28Z","timestamp":1777588828000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1759720X251414604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":34,"alternative-id":["10.1177\/1759720X251414604"],"URL":"https:\/\/doi.org\/10.1177\/1759720x251414604","relation":{},"ISSN":["1759-720X","1759-7218"],"issn-type":[{"value":"1759-720X","type":"print"},{"value":"1759-7218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"1759720X251414604"}}