{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:44:35Z","timestamp":1777877075463,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Inflammatory processes play a central role in rheumatoid arthritis (RA), involving complex interactions among cytokines and blood cell components. Current clinical tools, including the Disease Activity Score (DAS28), and biomarkers such as erythrocyte sedimentation rate and C-reactive protein (CRP), have limitations in monitoring disease activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to assess the utility of routine hematological parameters as potential biomarkers for diagnosing RA and evaluating disease activity in drug-na\u00efve patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this single-center retrospective study, 486 RA patients and 301 age- and sex-matched healthy controls were analyzed. Drug-na\u00efve RA patients (not treated with disease-modifying antirheumatic drugs or glucocorticoids) were selected according to the 2010 American College of Rheumatology\/European League Against Rheumatism criteria. Hematological parameters (white blood cell count and differential, hemoglobin (HGB), platelet count (PLT), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), red cell distribution width (RDW), and mean platelet volume (MPV)) were obtained and calculated from complete blood counts. Disease activity was assessed using the 28-joint DAS28 with CRP. Diagnostic accuracy and association with disease activity were evaluated using receiver operating characteristic (ROC) analysis, correlation tests, and logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Compared with controls, RA patients exhibited distinct hematological profiles, with significantly higher NLR, PLR, and RDW, and lower MPV (all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Multivariate logistic regression identified MPV (odds ratio (OR): 1.315, 95% confidence interval (CI): 1.085\u20131.594,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.005) and age (OR: 0.984, 95% CI: 0.969\u20130.999,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.038) as independent factors associated with moderate-to-high disease activity. MPV showed significant inverse correlations with DAS28-CRP (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u2009\u22120.098,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.031) and CRP (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u2009\u22120.148,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001). ROC analysis demonstrated that NLR had a modest performance (area under the curve (AUC): 0.676) for distinguishing RA patients from controls, and its performance in differentiating disease activity levels was weak (AUC: 0.598).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study suggests that hematological indices, particularly NLR, PLR, and MPV, hold potential as supplementary biomarkers in RA, but not standalone diagnostic tools. MPV emerged as an independent marker associated with higher disease activity, yet its clinical significance requires further validation. These readily available parameters may be integrated as complementary components of a broader diagnostic and monitoring strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x261417917","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:53:22Z","timestamp":1770710002000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of hematological parameters as biomarkers of disease activity in drug-na\u00efve patients with rheumatoid arthritis: a retrospective analysis"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1440-0860","authenticated-orcid":false,"given":"Esra Dilsat","family":"Imrak","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Bal\u0131kesir Ataturk City Hospital, Bal\u0131kesir 10100, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alev","family":"Cetin Duran","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Basic Immunology, Bal\u0131kesir Ataturk City Hospital, Bal\u0131kesir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugur","family":"Ergun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Bal\u0131kesir Ataturk City Hospital, Bal\u0131kesir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihan","family":"Balta","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Antalya City Hospital, Antalya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betul","family":"Koyuncu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Izmir Cigli Training and Research Hospital, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215920"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12582"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13157"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejr.2017.05.001"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-1845-y"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103223441207"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03036"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176460"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26094065"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21649"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2012.01754.x"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00185"},{"issue":"1","key":"e_1_3_4_14_2","article-title":"A study on association between common haematological parameters and disease activity in rheumatoid arthritis","volume":"11","author":"Talukdar M","year":"2017","unstructured":"Talukdar M, Barui G, Adhikari A, et al. A study on association between common haematological parameters and disease activity in rheumatoid arthritis. 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Can mean platelet volume be a surrogate marker of \u0131nflammation in rheumatic diseases? West Indian Med J 2015; 65: 165\u2013169.","journal-title":"West Indian Med J"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.3109\/09537101003663758"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1345-1"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.1.1.1"}],"container-title":["Therapeutic Advances in Musculoskeletal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1759720X261417917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1759720X261417917","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1759720X261417917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:40:29Z","timestamp":1777588829000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1759720X261417917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":41,"alternative-id":["10.1177\/1759720X261417917"],"URL":"https:\/\/doi.org\/10.1177\/1759720x261417917","relation":{},"ISSN":["1759-720X","1759-7218"],"issn-type":[{"value":"1759-720X","type":"print"},{"value":"1759-7218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"article-number":"1759720X261417917"}}