{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:44:43Z","timestamp":1777877083564,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI23\/00046"],"award-info":[{"award-number":["PI23\/00046"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"instituto de salud carlos iii","doi-asserted-by":"publisher","award":["PI24\/00554"],"award-info":[{"award-number":["PI24\/00554"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Red de Investigaci\u00f3n RICORS","award":["RD24\/0007\/0031"],"award-info":[{"award-number":["RD24\/0007\/0031"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Interleukin 8 (IL-8) is a chemokine involved in the pathogenesis of rheumatoid arthritis (RA). However, the clinical significance of its circulating levels remains poorly defined, partly due to technical challenges in measuring IL-8 in serum. Consequently, data on the relationship between serum IL-8 concentrations and specific disease manifestations in RA are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>In this study, we aimed to investigate the associations between serum IL-8 levels and clinical, serological, and cardiovascular features in patients with RA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 216 RA patients were recruited. They underwent comprehensive evaluations, including disease-related characteristics and disease activity indices. Moreover, complete lipid profile, insulin resistance indices, metabolic syndrome criteria, and carotid ultrasound for carotid stiffness, intima-media thickness and carotid plaque detection were assessed. The SCORE2 \u2013Systemic Cardiovascular Risk Estimation\u2013 was also calculated. IL-8 serum levels were measured using Simoa (Single Molecule Array) technique. A multivariable linear regression analysis was performed to examine the associations between disease characteristics and IL-8.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>C-reactive protein and IL-6 were significantly associated with higher IL-8 levels after multivariable adjustment. Likewise, disease activity scores were independently and positively correlated with higher serum IL-8 concentrations after adjustment for covariates. In contrast, rheumatoid factor and anti-citrullinated protein antibodies positivity showed no association with IL-8 levels. With respect to cardiovascular features, higher SCORE2 and carotid intima media thickness values were positively related to increased IL-8 concentrations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Serum IL-8 levels are independently and positively associated with disease activity scores in patients with RA. These findings suggest that IL-8 may have potential as a biomarker in this population but requires prospective validation and comparison with standard markers. The observed relationship between IL-8 levels and the SCORE2 risk calculator suggests a potential association between IL-8 and cardiovascular disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x261436835","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T09:51:15Z","timestamp":1776678675000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum interleukin-8 levels relate to disease activity in patients with rheumatoid arthritis"],"prefix":"10.1177","volume":"18","author":[{"given":"Diamela","family":"Le\u00f3n-Cabrera","sequence":"first","affiliation":[{"name":"Division of Rehabilitation, Hospital Universitario de Canarias, Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"Quevedo-Abeledo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Hospital Doctor Negr\u00edn, Las Palmas de Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Almeida-Santiago","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Hospital Doctor Negr\u00edn, Las Palmas de Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Garc\u00eda-Barrera","sequence":"additional","affiliation":[{"name":"Division of Immunology, Hospital Ram\u00f3n y Cajal, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa M.","family":"Villar","sequence":"additional","affiliation":[{"name":"Division of Immunology, Hospital Ram\u00f3n y Cajal, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Quiroga-Colina","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier Gonzalo","family":"Ocejo-Vinyals","sequence":"additional","affiliation":[{"name":"Department of Immunology, Hospital Universitario Marqu\u00e9s de Valdecilla, IDIVAL, Santander, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Javier-Ormaz\u00e1bal","sequence":"additional","affiliation":[{"name":"Division of Rehabilitation, Hospital Universitario de Canarias, Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7924-7406","authenticated-orcid":false,"given":"Miguel \u00c1.","family":"Gonz\u00e1lez-Gay","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Av. de los Reyes Cat\u00f3licos, 2, Madrid 28040, Spain"},{"name":"Department of Medicine and Psychiatry, University of Cantabria, Santander, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0197-5267","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Ferraz-Amaro","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Hospital Universitario de Canarias, Tenerife, Santander 38320, Spain Department of Internal Medicine, University of La Laguna (ULL), Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.155828"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2016.1240766"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.2741\/2853"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000350282"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.020529"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2023.07.014"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.7326\/AITC201901010"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30173-8"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000470"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2008.02.001"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.07.026"},{"key":"e_1_3_4_13_2","first-page":"2013","article-title":"Metabolic syndrome in rheumatoid arthritis","author":"Ferraz-Amaro I","year":"2013","unstructured":"Ferraz-Amaro I, Gonz\u00e1lez-Juanatey C, L\u00f3pez-Mejias R, et al. 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