{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:44:37Z","timestamp":1777877077310,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100022720","name":"Health Bureau","doi-asserted-by":"publisher","award":["The Health and Medical Research Fund Project NO: 0"],"award-info":[{"award-number":["The Health and Medical Research Fund Project NO: 0"]}],"id":[{"id":"10.13039\/100022720","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Rheumatoid arthritis is a chronic inflammatory disease with progressive joint destruction resulting in functional loss. High-resolution peripheral quantitative CT (HR-pQCT) is a novel technique for detailed volumetric assessment of joint space morphology and bone erosions. We hypothesized that effective control of inflammation in early rheumatoid arthritis (ERA) patients who can achieve sustained simple disease activity index (SDAI) remission will have less progression of joint damage and functional loss than patients who cannot achieve sustained SDAI remission (SDI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To elucidate the effects of achieving SDI on the progression of joint space outcomes in patients with ERA assessed using HR-pQCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This was a prospective study with 109 participants receiving 1-year tight-control treatment aiming at SDAI remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 109 patients received 1-year tight-control treatment aiming at SDAI remission. SDI was defined as achieving SDAI remission at months 6, 9, and 12. The primary outcome was the change in joint space size and volume at metacarpophalangeal joints 2\u20134, determined using HR-pQCT at 12\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At 12\u2009months, HR-pQCT image analysis showed that 14 out of 109 (12.8%) patients achieved SDI (SDI group). No significant differences in changes in joint space and erosion parameters were observed between the SDI and non-SDI groups. Erosion volume was reduced significantly in both groups. While new erosions (0% vs 16%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.338) and erosion progression (0% vs 27.3%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.592) were only observed in the non-SDI group, partial erosion healing was numerically more frequently observed in the SDI group (27.3% vs 10.3%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.260). At baseline, disease activity parameters were positively correlated with joint space parameters, while after 12\u2009months, a negative correlation emerged between disease activity parameters and both mean joint space width (JSW) and minimum JSW.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although HR\u2011pQCT did not show a significant difference in joint damage progression at 12\u2009months between patients with and without sustained remission, the overall cohort\u2014managed with a tight-control strategy targeting SDAI remission\u2014exhibited minimal bone and joint damage progression over 1\u2009year.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x261439714","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:24:40Z","timestamp":1775780680000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of achieving simple disease activity index remission on joint space outcomes progression in early rheumatoid arthritis: an exploratory study using high-resolution peripheral quantitative computed tomography"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6898-8045","authenticated-orcid":false,"given":"Qihan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho","family":"So","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac T.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingzhao","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sze-Lok","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tin-Yuet","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Qin","sequence":"additional","affiliation":[{"name":"Bone Quality and Health Centre, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian W.","family":"Hung","sequence":"additional","affiliation":[{"name":"Bone Quality and Health Centre, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F","family":"Griffith","sequence":"additional","affiliation":[{"name":"Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kitty","family":"Kwok","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen Elizabeth Hospital, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Yim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tseung Kwan O Hospital, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Medicine, Princess Margaret Hospital, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ka Lai Violet","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack J. 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