{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:44:36Z","timestamp":1777877076786,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Body composition is increasingly recognized as an important modulator of chronic inflammation. However, the association between body composition parameters and disease activity in axial spondyloarthritis (axSpA) remains to be clearly established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We aimed to investigate the association between muscle, subcutaneous fat composition assessed via computed tomography (CT) imaging, and disease activity in patients with axSpA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This is a retrospective data registry observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study analyzed 215 patients with axSpA. Body composition parameters were measured from pelvic CT scans. Parameters included the total adipose tissue volume to total skeletal muscle volume ratio (TATV\/TSMV), a single-slice subcutaneous adipose tissue to skeletal muscle area ratio (SAT\/SM), and skeletal muscle (SM) radiodensity. Disease activity was evaluated using the Ankylosing Spondylitis Disease Activity Score (ASDAS). Associations were analyzed using multivariate linear regression and restricted cubic splines (RCS). The probability of achieving major improvement (MI, \u0394ASDAS 2.0) was compared using Kaplan\u2013Meier analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      After adjusting for age, sex, and disease duration, a higher TATV\/TSMV ratio, rather than the single-slice SAT\/SM ratio, was independently associated with increased ASDAS-C-reactive protein (\u03b2\u2009=\u20090.722, 95% confidence interval (CI): 0.215\u20131.231,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.004). SM radiodensity showed an inverse, nonsignificant association (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.48). RCS analysis identified a threshold effect of the TATV\/TSMV ratio on disease activity at 0.65 (nonlinear\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.045). Above this threshold, a higher ratio was significantly associated with elevated ASDAS-CRP (hazard ratio (HR)\u2009=\u20093.64, 95% CI: 1.13\u201311.71,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.029). Patients with a ratio &lt;0.65 had a significantly higher probability of achieving MI (HR\u2009=\u20091.64, 95% CI: 1.04\u20132.59, log-rank\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The pelvic TATV\/TSMV ratio is an independent imaging biomarker associated with higher disease activity and lower odds of clinical improvement in patients with axSpA. A cut-off value of 0.65 may be a promising tool for risk stratification in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x261442029","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:01:35Z","timestamp":1776427295000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of muscle mass, adipose tissue mass, and skeletal muscle radiodensity with disease activity in axial spondyloarthritis"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4923-5882","authenticated-orcid":false,"given":"Ran","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3539-2492","authenticated-orcid":false,"given":"Xin-Yu","family":"Song","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Yong","family":"Wei","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Li","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Er","family":"Wei","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai 200233, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Ming","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai 200233, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31591-4"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138594"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex187"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae133"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0509-6"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-025-09088-8"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001225"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-020-00917-4"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22932"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2014.12.006"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew326"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202812"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2023.103357"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket433"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203643"},{"key":"e_1_3_4_17_2","first-page":"144","article-title":"The role of obesity on inflammation and damage in spondyloarthritis: a systematic literature review on body mass index and imaging","volume":"38","author":"Bakirci S","year":"2020","unstructured":"Bakirci S, Dabague J, Eder L, et al. The role of obesity on inflammation and damage in spondyloarthritis: a systematic literature review on body mass index and imaging. Clin Exp Rheumatol 2020; 38: 144\u2013148.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7678183"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X18783894"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.06.017"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1550-8528.1996.tb00510.x"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.5"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-022-06439-x"},{"key":"e_1_3_4_24_2","first-page":"1163","article-title":"Equivalent cut-off values of Bath Ankylosing Spondylitis Disease Activity Index corresponding to Ankylosing Spondylitis Disease Activity Score cut-off values","volume":"41","author":"Cui R","year":"2023","unstructured":"Cui R, Du Y, Tian N, et al. 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