{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:12:18Z","timestamp":1788667938738,"version":"build-2803163510"},"reference-count":63,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.82572821, No.82571788, No.82402867 and No.32530058"],"award-info":[{"award-number":["No.82572821, No.82571788, No.82402867 and No.32530058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Postdoctoral Research Fund of West China Hospital, Sichuan University","award":["No.HXBH042"],"award-info":[{"award-number":["No.HXBH042"]}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["No.2026NSFSC1809 and No.2024NSFSC0002"],"award-info":[{"award-number":["No.2026NSFSC1809 and No.2024NSFSC0002"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Musculoskeletal"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Metabolic dysfunction may contribute to osteoarthritis (OA), but routine markers for identifying future OA risk remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine associations of triglyceride-glucose (TyG) and adiposity-integrated TyG indices with hospital-recorded incident OA, and whether these associations differed by cardiometabolic disease (CMD) burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective cohort study using UK Biobank data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 255,232 participants without baseline OA and with complete exposure, covariate, and selected metabolomic data. Baseline TyG, TyG-body mass index (BMI), TyG-waist circumference (WC), and TyG-waist-to-height ratio (WHtR) were analyzed in quartiles. CMD burden was categorized as no CMD, one CMD, or cardiometabolic multimorbidity (CMM). Hospital-recorded incident OA was identified from linked hospital inpatient records using ICD-10 codes M15-M19. Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for demographic, socioeconomic, and lifestyle factors. Restricted cubic spline, stratified, and joint exposure analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During follow-up, 43,554 participants developed OA. Compared with the lowest quartile, the highest quartile was associated with a higher risk of hospital-recorded incident OA for TyG-BMI (HR 2.18, 95% CI 2.12\u20132.24), TyG-WC (HR 2.14, 95% CI 2.08\u20132.21), and TyG-WHtR (HR 2.00, 95% CI 1.94\u20132.06), whereas TyG alone showed only a weak association (HR 1.03, 95% CI 1.00\u20131.06). CMD burden was independently associated with OA risk (one CMD: HR 1.37, 95% CI 1.29-1.46; CMM: HR 1.44, 95% CI 1.31-1.58). Across CMD strata, the strongest associations were observed among participants with CMM, with HRs of 2.05 (95% CI 1.61\u20132.61), 1.99 (95% CI 1.61\u20132.46), and 1.97 (95% CI 1.56\u20132.49) for TyG-BMI, TyG-WC, and TyG-WHtR, respectively. No statistically significant interactions were detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adiposity-integrated TyG indices and greater CMD burden were associated with hospital-recorded incident OA, whereas TyG alone showed only a weak association. Joint-category analyses showed higher observed risk estimates among participants with both characteristics, without evidence of multiplicative interaction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1759720x261485407","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:11:35Z","timestamp":1788430295000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Triglyceride-glucose related indices, cardiometabolic multimorbidity, and risk of incident osteoarthritis: A prospective cohort study in UK Biobank"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1002-4597","authenticated-orcid":false,"given":"Kai-Bo","family":"Sun","sequence":"first","affiliation":[{"name":"West China Hospital of Sichuan 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Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Qi","family":"Xie","sequence":"additional","affiliation":[{"name":"West China Hospital of Sichuan University"},{"name":"West China Hospital"},{"name":"Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Shen","sequence":"additional","affiliation":[{"name":"West China Hospital of Sichuan 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