{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:05:14Z","timestamp":1791270314314,"version":"4.1.0"},"reference-count":181,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["R35GM124677"],"award-info":[{"award-number":["R35GM124677"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Nanobiomedicine"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:p> Excitotoxicity is a primary pathological process that occurs during stroke, traumatic brain injury (TBI), and global brain ischemia such as perinatal asphyxia. Excitotoxicity is triggered by an overabundance of excitatory neurotransmitters within the synapse, causing a detrimental cascade of excessive sodium and calcium influx, generation of reactive oxygen species, mitochondrial damage, and ultimately cell death. There are multiple potential points of intervention to combat excitotoxicity and downstream oxidative stress, yet there are currently no therapeutics clinically approved for this specific purpose. For a therapeutic to be effective against excitotoxicity, the therapeutic must accumulate at the disease site at the appropriate concentration at the right time. Nanotechnology can provide benefits for therapeutic delivery, including overcoming physiological obstacles such as the blood\u2013brain barrier, protect cargo from degradation, and provide controlled release of a drug. This review evaluates the use of nano-based therapeutics to combat excitotoxicity in stroke, TBI, and hypoxia\u2013ischemia with an emphasis on mitigating oxidative stress, and consideration of the path forward toward clinical translation. <\/jats:p>","DOI":"10.1177\/1849543520970819","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T11:20:53Z","timestamp":1604488853000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Nanotherapeutic modulation of excitotoxicity and oxidative stress in acute brain injury"],"prefix":"10.1177","volume":"7","author":[{"given":"Rick","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-7068","authenticated-orcid":false,"given":"Elizabeth","family":"Nance","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, University of Washington, Seattle, WA, USA"},{"name":"Department of Radiology, University of Washington, Seattle, WA, USA"},{"name":"Center on Human Development and Disability, University of Washington, Seattle, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,11,4]]},"reference":[{"key":"bibr1-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000485"},{"key":"bibr2-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.05.010"},{"key":"bibr3-1849543520970819","unstructured":"Peterson AB, Xu L, Daugherty J, et al. Surveillance report of traumatic brain injury-related emergency department visits, hospitalizations, and deaths, United States, 2014. Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, 2019."},{"key":"bibr4-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12727"},{"key":"bibr5-1849543520970819","first-page":"45","volume-title":"Brain Injury Medicine","author":"Coronado V","year":"2012"},{"key":"bibr6-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2015.03.004"},{"key":"bibr7-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-014-1187-1"},{"key":"bibr8-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1422"},{"key":"bibr9-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.4.1007S"},{"key":"bibr10-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011353"},{"key":"bibr11-1849543520970819","doi-asserted-by":"publisher","DOI":"10.3390\/cells8020184"},{"key":"bibr12-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-010-0481-0"},{"key":"bibr13-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0133-09.2009"},{"key":"bibr14-1849543520970819","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00469"},{"key":"bibr15-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1995.52"},{"key":"bibr16-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1186\/1749-7922-4-7"},{"key":"bibr17-1849543520970819","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666170613083606"},{"key":"bibr18-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199705000-00001"},{"key":"bibr19-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2009.24"},{"key":"bibr20-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-015-1622-1"},{"key":"bibr21-1849543520970819","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00199"},{"key":"bibr22-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00139.2004"},{"key":"bibr23-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.10.397"},{"key":"bibr24-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00063.2013"},{"key":"bibr25-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145750"},{"key":"bibr26-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00472.2009"},{"key":"bibr27-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200314172"},{"key":"bibr28-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(98)00035-2"},{"key":"bibr29-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68052038.x"},{"key":"bibr30-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1159\/000489241"},{"key":"bibr31-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.271.5.C1424"},{"key":"bibr32-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-014-9588-2"},{"key":"bibr33-1849543520970819","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-100465"},{"key":"bibr34-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02316-X"},{"key":"bibr35-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.08.015"},{"key":"bibr36-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.01.034"},{"key":"bibr37-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00057.x"},{"key":"bibr38-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2013"},{"key":"bibr39-1849543520970819","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.2.1046"},{"key":"bibr40-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.3968"},{"key":"bibr41-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-018-2104-y"},{"key":"bibr42-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0241-4"},{"key":"bibr43-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2004.01.005"},{"key":"bibr44-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-7-74"},{"key":"bibr45-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2013.89"},{"key":"bibr46-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.06.008"},{"key":"bibr47-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1177\/1545968313491007"},{"key":"bibr48-1849543520970819","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00172"},{"key":"bibr49-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(02)00164-3"},{"key":"bibr50-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707697200"},{"key":"bibr51-1849543520970819","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.12.122"},{"key":"bibr52-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1159\/000446160"},{"key":"bibr53-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2012.2712"},{"key":"bibr54-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1038\/nature10841"},{"key":"bibr55-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.506048"},{"key":"bibr56-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9488-4"},{"key":"bibr57-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2554"},{"key":"bibr58-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.677922"},{"key":"bibr59-1849543520970819","unstructured":"Leufkens PW. 2-iminobiotin formulations and uses thereof. Google Patents, 2015."},{"key":"bibr60-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/318087"},{"key":"bibr61-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1159\/000355621"},{"key":"bibr62-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184643"},{"key":"bibr63-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.08.032"},{"key":"bibr64-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.03.090"},{"key":"bibr65-1849543520970819","doi-asserted-by":"publisher","DOI":"10.2217\/cnc-2016-0016"},{"key":"bibr66-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2008.11.077"},{"key":"bibr67-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1080\/17461391.2018.1500644"},{"key":"bibr68-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2011.2228"},{"key":"bibr69-1849543520970819","first-page":"89","volume-title":"Chapter 7\u2014Challenges and barriers","author":"Elizabeth Nance MM","year":"2019"},{"key":"bibr70-1849543520970819","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S36111"},{"key":"bibr71-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2009.06.022"},{"key":"bibr72-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2004.10.017"},{"key":"bibr73-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioeng.2004.12.003"},{"key":"bibr74-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1021\/la904114u"},{"key":"bibr75-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.06.031"},{"key":"bibr76-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.2.1.3"},{"key":"bibr77-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-011-0125-x"},{"key":"bibr78-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2017.10.001"},{"key":"bibr79-1849543520970819","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00040"},{"key":"bibr80-1849543520970819","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082721"},{"key":"bibr81-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(98)00085-4"},{"key":"bibr82-1849543520970819","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00021"},{"key":"bibr83-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1080\/10611860290031877"},{"key":"bibr84-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3330"},{"key":"bibr85-1849543520970819","doi-asserted-by":"crossref","first-page":"e10153","DOI":"10.1002\/btm2.10153","volume":"5","author":"Nowak M","year":"2019","journal-title":"Bioeng Transl Med"},{"key":"bibr86-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2019.08.008"},{"key":"bibr87-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.03.007"},{"key":"bibr88-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003594"},{"key":"bibr89-1849543520970819","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2013.801050"},{"key":"bibr90-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.05.020"},{"key":"bibr91-1849543520970819","doi-asserted-by":"publisher","DOI":"10.7150\/thno.23459"},{"key":"bibr92-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1021\/mp500108p"},{"key":"bibr93-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc31463k"},{"key":"bibr94-1849543520970819","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01348"},{"key":"bibr95-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2006.01.003"},{"key":"bibr96-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00321"},{"key":"bibr97-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-008-8232-1"},{"key":"bibr98-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-116947"},{"key":"bibr99-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.209"},{"key":"bibr100-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1007\/BF00968993"},{"key":"bibr101-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.9.1312"},{"key":"bibr102-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410210604"},{"key":"bibr103-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.02.038"},{"key":"bibr104-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.07.044"},{"key":"bibr105-1849543520970819","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13036-020-0226-8","volume":"14","author":"Liao R","year":"2020","journal-title":"J Biol Eng"},{"key":"bibr106-1849543520970819","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.11.32"},{"key":"bibr107-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.362"},{"key":"bibr108-1849543520970819","doi-asserted-by":"publisher","DOI":"10.7150\/thno.19979"},{"key":"bibr109-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.12.009"},{"key":"bibr110-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03309-4"},{"key":"bibr111-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1080\/87559129.2013.853772"},{"key":"bibr112-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026498209874"},{"key":"bibr113-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.10.012"},{"key":"bibr114-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120238"},{"key":"bibr115-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1039\/C8TB00107C"},{"key":"bibr116-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.06.060"},{"key":"bibr117-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1444"},{"key":"bibr118-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201203780"},{"key":"bibr119-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay9751"},{"key":"bibr120-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1021\/bk-2011-1083.ch009"},{"key":"bibr121-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1403.015"},{"key":"bibr122-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.01.129"},{"key":"bibr123-1849543520970819","first-page":"3099","volume":"7","author":"Zha YY","year":"2012","journal-title":"Int J Nanomedicine"},{"key":"bibr124-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(02)00056-1"},{"key":"bibr125-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/567073"},{"issue":"3","key":"bibr126-1849543520970819","first-page":"218","volume":"4","author":"Kim YO","year":"2008","journal-title":"Mol Cell Toxic"},{"key":"bibr127-1849543520970819","first-page":"378","volume":"15","author":"Vani JR","year":"2016","journal-title":"EXCLI J"},{"key":"bibr128-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1417047112"},{"key":"bibr129-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1038\/srep33808"},{"key":"bibr130-1849543520970819","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.15.51"},{"key":"bibr131-1849543520970819","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00199"},{"key":"bibr132-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1021\/nn302615f"},{"key":"bibr133-1849543520970819","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S157210"},{"key":"bibr134-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1134\/S199507801406010X"},{"key":"bibr135-1849543520970819","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00523"},{"key":"bibr136-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002482"},{"key":"bibr137-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12313"},{"key":"bibr138-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.637090"},{"key":"bibr139-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2018.03.020"},{"key":"bibr140-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2015.11.019"},{"key":"bibr141-1849543520970819","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00233"},{"key":"bibr142-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2013.02.005"},{"key":"bibr143-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1007\/s00709-013-0516-9"},{"key":"bibr144-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b11013"},{"key":"bibr145-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.208"},{"key":"bibr146-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.07.009"},{"key":"bibr147-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-005-0649-1"},{"key":"bibr148-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.118.254961"},{"key":"bibr149-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2014.274"},{"key":"bibr150-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2020.102208"},{"key":"bibr151-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-019-00098-8"},{"key":"bibr152-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000102702.39608.82"},{"key":"bibr153-1849543520970819","doi-asserted-by":"publisher","DOI":"10.4103\/bc.bc_28_17"},{"key":"bibr154-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-019-0916-0"},{"key":"bibr155-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.08.025"},{"key":"bibr156-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1113\/JP274928"},{"key":"bibr157-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22016"},{"key":"bibr158-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.499822"},{"key":"bibr159-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.163"},{"key":"bibr160-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00347-6"},{"key":"bibr161-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199710200-00033"},{"key":"bibr162-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306284"},{"key":"bibr163-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-014-0319-5"},{"key":"bibr164-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100003097"},{"key":"bibr165-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1159\/000452859"},{"key":"bibr166-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2017.51"},{"key":"bibr167-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1620579114"},{"key":"bibr168-1849543520970819","doi-asserted-by":"publisher","DOI":"10.2741\/3677"},{"key":"bibr169-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199605000-00014"},{"key":"bibr170-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2012.11.026"},{"key":"bibr171-1849543520970819","first-page":"1627","volume":"71","author":"Konstantinidis A","year":"2011","journal-title":"J Trauma"},{"key":"bibr172-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1906661"},{"key":"bibr173-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310519"},{"key":"bibr174-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1038\/srep23430"},{"key":"bibr175-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20741"},{"key":"bibr176-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2013.03.038"},{"key":"bibr177-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23843"},{"key":"bibr178-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1063\/1.5117299"},{"key":"bibr179-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1516-2"},{"key":"bibr180-1849543520970819","first-page":"120","volume":"19","author":"Buetler TM","year":"2004","journal-title":"News Physiol Sci"},{"key":"bibr181-1849543520970819","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-018-0357-8"}],"container-title":["Nanobiomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1849543520970819","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1849543520970819","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1849543520970819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T03:31:53Z","timestamp":1728358313000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1849543520970819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":181,"alternative-id":["10.1177\/1849543520970819"],"URL":"https:\/\/doi.org\/10.1177\/1849543520970819","relation":{},"ISSN":["1849-5435","1849-5435"],"issn-type":[{"value":"1849-5435","type":"print"},{"value":"1849-5435","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,1]]},"article-number":"1849543520970819"}}