{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T01:48:19Z","timestamp":1790560099915,"version":"4.1.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Children's Orthopaedics"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the safety of growth-friendly instrumentation for early-onset scoliosis (EOS) in patients with spinal muscular atrophy (SMA) type 1 who received disease-modifying treatment (DMT) and analyze short-term efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective search was conducted between 2017 and 2023. Patients with genetically confirmed SMA type 1 who were surgically treated for spinal deformity and receiving DMTs (nusinersen, risdiplam, or onasemnogene abeparvovec) were included. SMA types 2 and 3 and patients who do not receive DMTs were excluded. Clinical and radiographic data were collected at preoperative, postoperative, and latest follow-up visits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty-eight patients (mean follow-up: 16\u2009months (range 2\u201341)) were included. The mean age at surgery was 60\u2009months (range 29\u201396). Fifteen were treated with dual magnetically controlled growing rods (MCGR), four with unilateral MCGR and a contralateral guided growth system, three with Vertical Expandable Prosthetic Titanium Rib (VEPTR\u00ae) implants, five with self-distracting systems, and one with traditional dual growing rods. The mean amount of correction was 57% (44\u00b0\u00b1\u200917) for scoliosis and 83% (13\u00b0\u00b1\u200911) for pelvic obliquity. The mean T1-12 height gain during surgery was 31\u2009mm (\u00b116\u2009mm), while the mean T1\u2009S1 height gain was 51\u2009mm (\u00b124\u2009mm), and instrumented growth was observed during follow-up. Five patients (18%) developed six serious adverse events: three surgical site infections, two anchor failures, and one rod fracture, and all required unplanned reoperations. No neurologic complication, difficulty during nusinersen injections, or respiratory decline was recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We report that spinal deformity in this population can be safely treated with growth-friendly instrumentation, with similar complication rates when compared with SMA type 2.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/18632521231214780","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T05:49:56Z","timestamp":1701064196000},"page":"26-32","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Safety and efficacy of growth-friendly instrumentation for early-onset scoliosis in patients with spinal muscular atrophy type 1 in the disease-modifying treatment era"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9390-4129","authenticated-orcid":false,"given":"Riza Mert","family":"Cetik","sequence":"first","affiliation":[{"name":"Orthopedics and Traumatology, Pursaklar State Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dror","family":"Ovadia","sequence":"additional","affiliation":[{"name":"Dana-Dwek Children\u2019s Hospital, Tel Aviv Medical Center, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiril","family":"Mladenov","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopaedic Surgery, Children\u2019s Hospital Hamburg-Altona, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moyo C","family":"Kruyt","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkka","family":"Helenius","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Ahonen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopedics and Traumatology, Children\u2019s Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Studer","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, University Children\u2019s Hospital Basel (Universitats Kinderspital beider Basel), Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muharrem","family":"Yazici","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Hacettepe University Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2015.03.010"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90460-3"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2016.12.008"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2016.00007"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S214174"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/088307388900400208"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007742"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3182194937"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0b013e31821722b1"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-020-06564-8"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79821-x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3233\/JND-200533"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000001179"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2018.08.017"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0000000000000275"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-020-06612-3"},{"issue":"4","key":"e_1_3_2_18_2","first-page":"00089","article-title":"One-way self-expanding rod in neuromuscular scoliosis: preliminary results of a prospective series of 21 patients","volume":"6","author":"Gaume M","year":"2021","unstructured":"Gaume M, Hajj R, Khouri N, et al. 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