{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:55:16Z","timestamp":1793764516944,"version":"4.6.1"},"reference-count":22,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Children's Orthopaedics"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To assess ultrasonographic features of hip morphology in mucopolysaccharidosis type I Hurler.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Acetabular bony rim, acetabular cartilaginous roof, alpha and beta angles, echogenicity, and hip coverage were analyzed in eight mucopolysaccharidosis type I Hurler syndrome children before and after hematopoietic stem cell gene therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Sixteen hips at baseline, 10 at +12\u2009months, and 10 at + 24\u2009months after hematopoietic stem cell gene therapy were evaluated. The median age was 22, 35, and 45\u2009months at baseline evaluation, +12, and +24\u2009months, respectively. Acetabular bony rim at baseline was angular in 2\/16, rounded in 10\/16, notched in 2\/16, and flattened in 2\/16; at +12\u2009months, angular in 2\/10, rounded in 5\/10, notched in 3\/10; at +24\u2009months, angular in 2\/10, rounded in 3\/10, irregular in 1\/10, and notched in 4\/10. Acetabular cartilaginous roof at baseline was normal in 4\/16, enlarged in 12\/16; at +12\u2009months, enlarged in 10\/10 and at +24\u2009months, enlarged in 8\/10 and normal in 2\/10. Echogenicity of the joint capsule at baseline was normal in 10\/16, increased in 6\/16; at +12\u2009months, normal in 8\/10, increased in 2\/10; at +24\u2009months, normal in 6\/10, increased in 4\/10. The mean femoral head coverage was 60% at baseline (16\/16), 62% at +12\u2009months (10\/10), and 52% at +24\u2009months (2\/10). The mean alpha angle was 60\u00b0 at baseline (16\/16), 64\u00b0 at +12\u2009months (10\/10), and 60\u00b0 (2\/10) at +24\u2009months. The mean beta angle was 67\u00b0 at baseline (16\/16), 65\u00b0 at +12\u2009months (10\/10), and 49\u00b0 at +24\u2009months (8\/10).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Hip morphology of children with mucopolysaccharidosis type I Hurler syndrome before and after hematopoietic stem cell gene therapy can be evaluated by available ultrasound techniques until a median age of 45\u2009months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/18632521251349438","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T07:02:06Z","timestamp":1754895726000},"page":"377-385","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Ultrasonographic hip morphology in mucopolysaccharidosis type I Hurler after hematopoietic stem cell gene therapy"],"prefix":"10.1177","volume":"19","author":[{"given":"Maurizio","family":"De Pellegrin","sequence":"first","affiliation":[{"name":"San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Filisetti","sequence":"additional","affiliation":[{"name":"Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy"},{"name":"\u201cVita-Salute\u201d San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Cossutta","sequence":"additional","affiliation":[{"name":"San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), San Raffaele Scientific Institute, Milan, Italy"},{"name":"Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy"},{"name":"Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Colombo","sequence":"additional","affiliation":[{"name":"Radiology Unit, San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Consiglieri","sequence":"additional","affiliation":[{"name":"Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy"},{"name":"Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Tucci","sequence":"additional","affiliation":[{"name":"Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Aiuti","sequence":"additional","affiliation":[{"name":"San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), San Raffaele Scientific Institute, Milan, Italy"},{"name":"Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy"},{"name":"\u201cVita-Salute\u201d San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Ester","family":"Bernardo","sequence":"additional","affiliation":[{"name":"San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), San Raffaele Scientific Institute, Milan, Italy"},{"name":"Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy"},{"name":"\u201cVita-Salute\u201d San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"e_1_3_2_2_2","volume-title":"The Metabolic and Molecular Basis of Inherited Disease","author":"Neufeld EF","year":"2001","unstructured":"Neufeld EF, Muenzer J. The mucopolysaccharidoses. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The Metabolic and Molecular Basis of Inherited Disease. 8th ed. 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