{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:31:02Z","timestamp":1781721062158,"version":"3.54.5"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Hacettepe University Scientific Research Unit","award":["Project ID: TTU-2020- 18474"],"award-info":[{"award-number":["Project ID: TTU-2020- 18474"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Biomarkers"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background and Aim:<\/jats:bold>\n                    Malignant pleural effusion (MPE) is a common clinical problem. Management options are mainly pleurodesis and drainage, and have remained unchanged for years. Novel therapies that target the molecules responsible for fluid formation are needed to reduce the need for invasive procedures. The aim of this study is to investigate the potential role of MCP-1 in the development of MPE in patients with metastatic pleural malignancies.\n                    <jats:bold>Methods:<\/jats:bold>\n                    Pleural effusion samples (8\u201310\u2005ml) were collected from 100 patients who were divided into three groups: Group 1 (MPE, n\u2009=\u200956), Group 2 (benign exudate, n\u2009=\u200927) and Group 3 (transudate, n\u2009=\u200917). The collected effusions were promptly centrifuged at 4\u00b0C, and the supernatants were stored at \u221280\u00b0C. MCP-1 levels were determined by ELISA kit (USCN, Wuhan).\n                    <jats:bold>Results:<\/jats:bold>\n                    Median MCP-1 levels were found to be significantly different between the three groups (Group 1: 1303\u2005pg\/ml, Group 2: 926\u2005pg\/ml, Group 3: 211\u2005pg\/ml) (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). MCP-1 levels were markedly higher but similar in Group 1 and Group 2, as compared to Group 3. When patients from Group 1 and Group 2 were combined, a positive correlation was observed between pleural fluid MCP-1 and LDH levels (r\u2009=\u20090.38;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.001). Additionally, MCP-1 levels were observed to increase significantly as the volume of pleural fluid increased (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.007).\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    MCP-1 levels were found to be similarly high in both Group 1 (MPE) and Group 2 (Benign exudate), indicating that inflammation accompanying the tumor could play a role in the formation of pleural effusion. This suggests that the development of biological therapies targeting MCP-1 could be a promising approach in the future management of MPE.\n                  <\/jats:p>","DOI":"10.1177\/18758592241293231","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T04:52:43Z","timestamp":1742446363000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["A potential target for the future treatment of malignant pleural effusion: Monocyte chemoattractant protein-1 (MCP-1)"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6688-1427","authenticated-orcid":false,"given":"Fatih","family":"Tekin","sequence":"first","affiliation":[{"name":"Department of Chest Diseases, Hacettepe University Medical Faculty, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Koksal","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Hacettepe University Medical Faculty, Ankara, Turkey"},{"name":"Mesothelioma and Medical Geology Application and Research Center, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z Gunnur","family":"Dikmen","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Hacettepe University Medical Faculty, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevilay","family":"Karahan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Hacettepe University Medical Faculty, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u0131dvan","family":"Bayler","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases, Hacettepe University Medical Faculty, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcu","family":"Anc\u0131n","sequence":"additional","affiliation":[{"name":"Department of Chest Surgery, Hacettepe University Medical Faculty, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkan","family":"Dikmen","sequence":"additional","affiliation":[{"name":"Department of Chest Surgery, Hacettepe University Medical Faculty, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devrim","family":"Akinci","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hacettepe University Medical Faculty, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevgen","family":"Onder","sequence":"additional","affiliation":[{"name":"Mesothelioma and Medical Geology Application and Research Center, Hacettepe University, Ankara, Turkey"},{"name":"Department of Pathology, Hacettepe University Medical Faculty, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136994"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e3283615b67"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000267"},{"key":"e_1_3_5_5_2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0096-5588(20)32384-9","article-title":"Pleural poudrage: a new technic for the deliberate production of pleural adhesions as a preliminary to lobectomy","volume":"4","author":"Bethune N","year":"1935","unstructured":"Bethune N. 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