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CD-30 was up-regulated in metastatic CC, BLC was up-regulated in metastatic LCC and CD-40L was down-regulated in metastatic RCC. MDC and MMP-1 were positively associated, while IL-9 and VEGF-A were negatively associated with lymph nodes invasion in CC. Up-regulation of IL-12p70 and MMP-1 in LCC with lymph nodes invasion contrasted with down-regulation of IL-9 and MIP-1beta. IL-23, I-TAC, and SDF-1\u03b1 were negatively associated with resistant CC to Folfox chemotherapy, and I-TAC was down-regulated in resistant LCC. IL-2 and FGF-2 were down-regulated, while APRIL was up-regulated in resistant RCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study revealed significant differences in serum protein levels between LCC and RCC emphasizing the importance to explore novel theranostic biomarkers for CC, associated with resistance or sensitivity to chemotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/18758592251329321","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T10:46:30Z","timestamp":1744713990000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Protein Profiling as theranostic biomarkers for Left- and Right-Sided Colon Cancer using Luminex\n                    <sup>\u00ae<\/sup>\n                    technology"],"prefix":"10.1177","volume":"42","author":[{"given":"Amani","family":"Attia","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Sciences of Tunis (FST), Laboratory of Mycology, Pathologies and Biomarkers (LR16ES05), University of Tunis El Manar (UTM), Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azza","family":"Habel","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences of Tunis (FST), Laboratory of Mycology, Pathologies and Biomarkers (LR16ES05), University of Tunis El Manar (UTM), Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weili","family":"Xu","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mouna","family":"Stayoussef","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences of Tunis (FST), Laboratory of Mycology, Pathologies and Biomarkers (LR16ES05), University of Tunis El Manar (UTM), Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amel","family":"Mezlini","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Salah Azaiez Oncology Institute, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anis","family":"Larbi","sequence":"additional","affiliation":[{"name":"Beckman Coulter Life Sciences, Ville pinte, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Besma","family":"Yaacoubi-Loueslati","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences of Tunis (FST), Laboratory of Mycology, Pathologies and Biomarkers (LR16ES05), University of Tunis El Manar (UTM), Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells11233744"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-06784-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4236\/jct.2023.146024"},{"key":"e_1_3_3_6_2","first-page":"173","article-title":"Does antiaggregant administration lead to early diagnosis in proximal colon cancer?","volume":"4","author":"Aday U","year":"2017","unstructured":"Aday U, Gundes E, Ciyiltepe H, et al. 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