{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:38:56Z","timestamp":1790019536754,"version":"4.0.1"},"reference-count":66,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Biomarkers"],"published-print":{"date-parts":[[2025,6]]},"abstract":"\n Background<\/jats:title>\n \n Considering the significance of circRNA-miRNA network underlying cervical cancer (CC) development, this investigation was devised to explore whether and how 6-methyladinosinek (m\n 6<\/jats:sup>\n A)-adjusted hsa_circ_0101308\/miR-224 axis participated in altering chemo-resistance in CC.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Forty-nine pairs of CC tissues and para-cancerous normal tissues were gathered, and CC cell lines, comprising HeLa, HeLa\/DDP, HeLa\/ADM and HeLa\/TAX cell lines, were pre-prepared. Expressions of circRNAs, miRNAs and mRNAs were determined using quantitative reverse transcription-polymerase chain reaction (qRT-PCR), and m\n 6<\/jats:sup>\n A-modification of hsa_circ_0101308 was verified based on methylated RNA immunoprecipitation sequencing (MeRIP-Seq) assay. Among CC cell lines, their chemo-resistance was evaluated through CCK8 assay, and their viability was assessed via MTT assay.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Hsa_circ_0101308 expression markedly dwindled, accompanied by notably elevated expression of miR-224, within CC tissues, when compared with para-cancerous normal tissues (\n P<\/jats:italic>\n \u2009<\u20090.05). Hsa_circ_0101308 sponed miR-224 and suppressed its expression in HeLa cell line (\n P<\/jats:italic>\n \u2009<\u20090.05), and either under-expressed m\n 6<\/jats:sup>\n A-adjusted hsa_circ_0101308 or over-expressed miR-224 strengthened viability of HeLa, HeLa\/DDP, HeLa\/ADM and HeLa\/TAX cell lines (\n P<\/jats:italic>\n \u2009<\u20090.05). Additionally, miR-224 targeted CADM1 and down-regulated its mRNA level (\n P<\/jats:italic>\n \u2009<\u20090.05), which influenced p-PI3K\/PI3K or p-Akt\/Akt ratio (\n P<\/jats:italic>\n \u2009<\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The network combined by m\n 6<\/jats:sup>\n A-adjusted hsa_circ_0101308 and miR-224 interfered with chemo-resistance in CC via acting upon CADM1 and PI3K\/AKT pathway, which was conducive to optimizing CC treatment.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/18758592251341157","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T03:11:09Z","timestamp":1750302669000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Hsa_circ_0101308 adjusted by N6-methyladenosine (m\n 6<\/sup>\n A) impacts chemo-resistance in cervical cancer via sponging miR-224"],"prefix":"10.1177","volume":"42","author":[{"given":"Li","family":"Shang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, People's Hospital affiliated to Hubei University of Medicine, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, People's Hospital affiliated to Hubei University of Medicine, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Taihe Hospital affiliated to Hubei University of Medicine, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0536-7903","authenticated-orcid":false,"given":"Zhuyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, People's Hospital affiliated to Hubei University of Medicine, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32470-X"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-2833"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.artmed.2023.102549"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13061226"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2015.03.235"},{"key":"e_1_3_4_8_2","first-page":"73","article-title":"Combinational therapies for the treatment of advanced cervical cancer","volume":"24","author":"Alfonso D-G","year":"2022","unstructured":"Alfonso D-G. Combinational therapies for the treatment of advanced cervical cancer. Expert Opin Pharmacother 2022; 24: 73\u201381.","journal-title":"Expert Opin Pharmacother"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-1384-3"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2021.04.014"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1960769"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgaa140"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203347"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-021-01361-3"},{"key":"e_1_3_4_15_2","first-page":"2209","article-title":"Reconstruction and analysis of circRNA-miRNA-mRNA network in the pathology of cervical cancer","volume":"41","author":"Yi Y","year":"2019","unstructured":"Yi Y, Liu Y, Wu W, et al. Reconstruction and analysis of circRNA-miRNA-mRNA network in the pathology of cervical cancer. Oncol Rep 2019; 41: 2209\u20132225.","journal-title":"Oncol Rep"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5435333"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23605"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-021-09627-8"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2022.01.013"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107641"},{"key":"e_1_3_4_21_2","first-page":"1","article-title":"Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus","volume":"10","author":"Zhao J","year":"2019","unstructured":"Zhao J, Lee EE, Kim J, et al. Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus. Nat Commun 2019; 10: 1\u201312.","journal-title":"Nat Commun"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.03.020"},{"key":"e_1_3_4_23_2","first-page":"1","article-title":"Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus","volume":"10","author":"Zhao J","year":"2019","unstructured":"Zhao J, Lee EE, Kim J, et al. Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus. Nat Commun 2019; 10: 1\u201312.","journal-title":"Nat Commun"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11743"},{"key":"e_1_3_4_25_2","article-title":"Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA","volume":"113","author":"Zhang C","year":"2016","unstructured":"Zhang C, Samanta D, Lu H, et al. Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA. Proc Natl Acad Sci U S A 2016; 113: E2047\u2013E2056.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.16"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0410-6"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.02.013"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.02.059"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.2217\/epi-2015-0019"},{"key":"e_1_3_4_31_2","first-page":"4826","article-title":"Identification of potential immune-related circRNA-miRNA-mRNA regulatory network in cutaneous squamous cell carcinoma","volume":"11","author":"Wei Y","year":"2021","unstructured":"Wei Y, Yang X, Gao L, et al. Identification of potential immune-related circRNA-miRNA-mRNA regulatory network in cutaneous squamous cell carcinoma. Am J Cancer Res 2021; 11: 4826\u20134843.","journal-title":"Am J Cancer Res"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.632359"},{"key":"e_1_3_4_33_2","first-page":"450","article-title":"MicroRNA-224 modulates chemosensitivity of breast cancer cells to docetaxel by apoptosis inhibitor 5","volume":"26","author":"Zhang J","year":"2021","unstructured":"Zhang J, Lu Y, Zhang Y, et al. MicroRNA-224 modulates chemosensitivity of breast cancer cells to docetaxel by apoptosis inhibitor 5. J B.U.ON. 2021; 26: 450\u2013458.","journal-title":"J B.U.ON."},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.157"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01268-5"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04193-7"},{"key":"e_1_3_4_37_2","first-page":"7407086","article-title":"miR-486 promotes the invasion and cell cycle progression of ovarian cancer cells by targeting CADM1","volume":"2021","author":"Li C","year":"2021","unstructured":"Li C, Wang Y, Wang H, et al. miR-486 promotes the invasion and cell cycle progression of ovarian cancer cells by targeting CADM1. Anal Cell Pathol (Amst) 2021; 2021: 7407086.","journal-title":"Anal Cell Pathol (Amst)"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2019_190106N18"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_3_4_40_2","first-page":"300060523116801","article-title":"Effect of CADM1 on TPF-induced chemotherapy in laryngeal squamous cell carcinoma","volume":"51","author":"Jiani N","year":"2023","unstructured":"Jiani N, Lianhe L, Fuxian T, et al. Effect of CADM1 on TPF-induced chemotherapy in laryngeal squamous cell carcinoma. J Int Med Res 2023; 51: 3000605231168017\u20133000605231168017.","journal-title":"J Int Med Res"},{"key":"e_1_3_4_41_2","article-title":"NCBI GEO: archive for functional genomics data sets\u2013update","volume":"41","author":"Tanya B","year":"2013","unstructured":"Tanya B, E WS, Pierre L, et al. NCBI GEO: archive for functional genomics data sets\u2013update. Nucleic Acids Res 2013; 41: D991\u2013D995.","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109717"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1501"},{"key":"e_1_3_4_44_2","first-page":"1111","article-title":"Cervical cancer: a meta-analysis, therapy and future of nanomedicine","volume":"14","author":"Venkatas J","year":"2020","unstructured":"Venkatas J, Singh M. Cervical cancer: a meta-analysis, therapy and future of nanomedicine. ecancermedicalscience 2020; 14: 1111.","journal-title":"ecancermedicalscience"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13051168"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204152"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20181641"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-020-03745-3"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01436-z"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102547"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01444"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.027"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12651-2"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.03.020"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.5676"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2013.10.014"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2014.3311"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.157"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.125"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-020-01701-z"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11725"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/jog.15576"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2019.1634578"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.688794"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1977053"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0303"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-015-0404-z"}],"container-title":["Cancer Biomarkers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/18758592251341157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/18758592251341157","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/18758592251341157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:11:25Z","timestamp":1777385485000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/18758592251341157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":66,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1177\/18758592251341157"],"URL":"https:\/\/doi.org\/10.1177\/18758592251341157","relation":{},"ISSN":["1574-0153","1875-8592"],"issn-type":[{"value":"1574-0153","type":"print"},{"value":"1875-8592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"article-number":"18758592251341157"}}