{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:43:31Z","timestamp":1777481011305,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Biomarkers"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gastric cancer is the 4th most common and 3rd deadliest cancer worldwide. Research has shown that PDCD2-like (PDCD2L) is elevated in several tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the relationship between PDCD2L expression and gastric cancer prognosis and its function in gastric cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Immunohistochemical staining and immunoblotting were performed to examine the expression of PDCD2L. The effect of PDCD2L on gastric cancer cells were evaluated by a series of in vitro cellular function experiments and in vivo proliferation experiments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PDCD2L was found to be overexpressed in gastric cancer tissues compared to non-tumor tissues, and its higher levels were associated with worse prognosis. In vitro experiments showed that reducing PDCD2L expression in gastric cancer cells led to decreased proliferation, migration, and invasion, with a similar effect observed in animal models. Knockdown of PDCD2L also resulted in lower expression of cell cycle- and motility-related proteins, while upregulation of PDCD2L had the opposite effect. Additionally, NGS analysis revealed that PDCD2L knockdown reduced the expression of RFX1, a gene linked to cell proliferation and migration, suggesting that PDCD2L and RFX1 together promote cancer progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PDCD2L could serve as a biomarker for gastric cancer prognosis and a potential therapeutic target.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/18758592251374857","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T12:21:16Z","timestamp":1756815676000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["PDCD2L overexpression represents an unfavorable prognostic marker and its inhibition shows promising therapeutic potential for gastric cancer"],"prefix":"10.1177","volume":"42","author":[{"given":"Ding-Ping","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan"},{"name":"Department of Food Science and Technology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Chao","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan"},{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsuan-Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nai-Weng","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You-Cheng","family":"Hseu","sequence":"additional","affiliation":[{"name":"Department of Cosmeceutics, China Medical University, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Feng","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Lang","family":"Fang","sequence":"additional","affiliation":[{"name":"TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"Department of Pathology, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-Yuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_3_3_3_2","first-page":"49","article-title":"Gastric cancer: clinical features, screening, diagnosis, treatment, and prevention","volume":"14","author":"Ramachandran R","year":"2024","unstructured":"Ramachandran R, Grantham T, Parvataneni S, et al. Gastric cancer: clinical features, screening, diagnosis, treatment, and prevention. J Community Hosp Intern Med Perspect 2024; 14: 49\u201357.","journal-title":"J Community Hosp Intern Med Perspect"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2024.01.003"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242015321"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/1354750X.2023.2206984"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-023-01429-7"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.22105"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.17130"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05822.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05481.x"},{"key":"e_1_3_3_12_2","article-title":"De-novo and acquired resistance to immune checkpoint targeting","volume":"12","author":"Syn NL","year":"2017","unstructured":"Syn NL, Teng MWL, Mok TSK, et al. De-novo and acquired resistance to immune checkpoint targeting. Lancet Oncol 2017; 12: e731\u2013e741.","journal-title":"Lancet Oncol"},{"key":"e_1_3_3_13_2","first-page":"1177","article-title":"PDCD5 Regulates cell proliferation, cell cycle progression and apoptosis","volume":"15","author":"Li P","year":"2018","unstructured":"Li P, Fei H, Wang L, et al. PDCD5 Regulates cell proliferation, cell cycle progression and apoptosis. Oncol Lett 2018; 15: 1177\u20131183.","journal-title":"Oncol Lett"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.31235"},{"key":"e_1_3_3_15_2","first-page":"241","article-title":"PDCD6 Promotes hepatocellular carcinoma cell proliferation and metastasis through the AKT\/GSK3\u03b2\/\u03b2-catenin pathway","volume":"36","author":"Wen SY","year":"2023","unstructured":"Wen SY, Liu YT, Wei BY, et al. PDCD6 Promotes hepatocellular carcinoma cell proliferation and metastasis through the AKT\/GSK3\u03b2\/\u03b2-catenin pathway. Biomed Environ Sci 2023; 36: 241\u2013252.","journal-title":"Biomed Environ Sci"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14235986"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5025"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204206"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1108"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1995.14.189"},{"key":"e_1_3_3_21_2","first-page":"10894","article-title":"Programmed cell death 2 functions as a tumor suppressor in osteosarcoma","volume":"8","author":"Yang Y","year":"2015","unstructured":"Yang Y, Jin Y, Du W. Programmed cell death 2 functions as a tumor suppressor in osteosarcoma. Int J Clin Exp Pathol 2015; 8: 10894\u201310900.","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2023.101106"},{"key":"e_1_3_3_23_2","first-page":"2173","article-title":"PDCD2 Sensitizes HepG2 cells to sorafenib by suppressing epithelial-mesenchymal transition","volume":"19","author":"Liu H","year":"2019","unstructured":"Liu H, Wang M, Liang N, et al. PDCD2 Sensitizes HepG2 cells to sorafenib by suppressing epithelial-mesenchymal transition. Mol Med Rep 2019; 19: 2173\u20132179.","journal-title":"Mol Med Rep"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.24484"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-022-02525-x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00361"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.09.034"},{"key":"e_1_3_3_28_2","first-page":"1116","article-title":"PDCD5 Inhibits osteosarcoma cell metastasis via targeting TGF-\u03b21\/Smad signaling pathway and is associated with good prognosis","volume":"11","author":"Zhao H","year":"2019","unstructured":"Zhao H, Peng C, Lu X, et al. PDCD5 Inhibits osteosarcoma cell metastasis via targeting TGF-\u03b21\/Smad signaling pathway and is associated with good prognosis. Am J Transl Res 2019; 11: 1116\u20131128.","journal-title":"Am J Transl Res"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204040"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2018.12.001"},{"key":"e_1_3_3_31_2","first-page":"2717","article-title":"A novel mechanism driving poor-prognostic gastric cancer: overexpression of the transcription factor Kr\u00fcppel-like factor 16 promotes growth and metastasis of gastric cancer through regulating the Notch pathway","volume":"11","author":"Sun DP","year":"2021","unstructured":"Sun DP, Tian YF, Lin CC, et al. A novel mechanism driving poor-prognostic gastric cancer: overexpression of the transcription factor Kr\u00fcppel-like factor 16 promotes growth and metastasis of gastric cancer through regulating the Notch pathway. Am J Cancer Res 2021; 11: 2717\u20132735.","journal-title":"Am J Cancer Res"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11030694"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-024-01044-x"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-01952-6"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.4137\/CIN.S7226"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-022-00794-w"}],"container-title":["Cancer Biomarkers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/18758592251374857","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/18758592251374857","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/18758592251374857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:11:25Z","timestamp":1777385485000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/18758592251374857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1177\/18758592251374857"],"URL":"https:\/\/doi.org\/10.1177\/18758592251374857","relation":{},"ISSN":["1574-0153","1875-8592"],"issn-type":[{"value":"1574-0153","type":"print"},{"value":"1875-8592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"article-number":"18758592251374857"}}