{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T19:46:35Z","timestamp":1787255195036,"version":"build-2736575974"},"reference-count":52,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"AHA Cardio-Oncology SFRN CAT-HD Center grant","award":["857078"],"award-info":[{"award-number":["857078"]}]},{"name":"Boston University Chobanian and Avedesian School of Medicine","award":["Center of Cross Organ Vascular Pathology and by th"],"award-info":[{"award-number":["Center of Cross Organ Vascular Pathology and by th"]}]},{"name":"NIH","award":["R01HL166608"],"award-info":[{"award-number":["R01HL166608"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Biomarkers"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a leading cause of morbidity and mortality in cancer patients. Prostate cancer is associated with an elevated risk of VTE, yet the molecular drivers remain poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we employed high-throughput proteomic profiling using the SomaLogic platform to analyze plasma from 85 prostate cancer patients, including 43 with and 42 without VTE. Samples were collected at cancer diagnosis, with VTE diagnosed at a mean of 96.8 months later.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Principal component analysis showed modest proteomic separation between groups. Differential expression analysis identified enriched pathways in VTE patients, including hemostasis (TIMP1, JAM2, TMX3, F3, and ESAM), cell adhesion (CXCL12, CCL11, CCN5, COL18A1, and ADGRB1) and cell proliferation (TIMP1, REG1B, REG1A, CRLF2, and ALDH1A2). Receiver Operating Characteristic analysis using top fifteen proteins achieved an area under the curve of 0.859, indicating strong predictive value for VTE in this cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We identified a specific cluster of circulating proteins associated with development of VTE in patients with prostate cancer. This work deepens understanding of systemic mediators of cancer-associated VTE and, pending validation in other cohorts, paves the way for improved risk stratification and long-term monitoring in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/18758592251390251","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T17:14:05Z","timestamp":1764954845000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A panel of plasma proteins associated with venous thromboembolism in patients with prostate cancer"],"prefix":"10.1177","volume":"42","author":[{"given":"Asha","family":"Jose","sequence":"first","affiliation":[{"name":"Renal Section, Department of Medicine, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA 02118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Lu","sequence":"additional","affiliation":[{"name":"Computational Biomedicine, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA 02118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Computational Biomedicine, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA 02118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"La","sequence":"additional","affiliation":[{"name":"Veterans Affairs Boston Healthcare System, Boston MA 02118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Young","sequence":"additional","affiliation":[{"name":"Veterans Affairs Boston Healthcare System, Boston MA 02118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Michael","family":"Gaziano","sequence":"additional","affiliation":[{"name":"Veterans Affairs Boston Healthcare System, Boston MA 02118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathanael R","family":"Fillmore","sequence":"additional","affiliation":[{"name":"Veterans Affairs Boston Healthcare System, Boston MA 02118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katya","family":"Ravid","sequence":"additional","affiliation":[{"name":"Department of Medicine and Whitaker Cardiovascular Institute, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA 02118, USA"},{"name":"Department of Biochemistry and Cell Biology, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA 02118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipul C","family":"Chitalia","sequence":"additional","affiliation":[{"name":"Renal Section, Department of Medicine, Boston University Chobanian &amp; Avedisian School of Medicine, Boston, MA 02118, USA"},{"name":"Veterans Affairs Boston Healthcare System, Boston MA 02118, USA"},{"name":"Institute of Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-024-03735-x"},{"key":"e_1_3_3_3_2","first-page":"5026","article-title":"Venous thromboembolism in cancer patients: still looking for answers","volume":"18","author":"Iorga RA","year":"2019","unstructured":"Iorga RA, Bratu OG, Marcu RD, et al. 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