{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:00:46Z","timestamp":1781100046197,"version":"3.54.1"},"reference-count":44,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Clinical Research Program of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine","award":["Grant No. JYLJ202205"],"award-info":[{"award-number":["Grant No. JYLJ202205"]}]},{"name":"Cross-disciplinary Research Fund of Shanghai Ninth People's Hospital","award":["JYJC202304"],"award-info":[{"award-number":["JYJC202304"]}]},{"name":"the Medical-Engineering Cross-Research Fund","award":["Grant No: YG2024QNA23 and YG2022QN056"],"award-info":[{"award-number":["Grant No: YG2024QNA23 and YG2022QN056"]}]},{"name":"the Shanghai Municipal Commission of Health and Family Planning","award":["Grant No. 172"],"award-info":[{"award-number":["Grant No. 172"]}]},{"name":"Fundamental research program funding of Ninth People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine","award":["JYZZ185"],"award-info":[{"award-number":["JYZZ185"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Biomarkers"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to identify DNA repair\u2013related genes causally affecting OCC risk by integrating multi-omics data using summary data\u2013based Mendelian randomization (SMR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>SMR analyses were performed using GWAS, mQTL, eQTL, and pQTL data. Causal associations were assessed via SMR and HEIDI tests, and colocalization analysis identified shared genetic variants. Findings were validated in the FinnGen_OCC cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study identified 160 methylation sites (96 genes), 30 eQTLs, and 2 pQTLs linked to OCC. Colocalization confirmed 96 mQTLs, 20 eQTLs, and 2 pQTLs (GPN1, HNRNPAB). Five mQTLs (ANK1, HLA C, TERT, TUBB, VHL) replicated in FinnGen. Integration of mQTL and eQTL data highlighted VHL, TP73, and JMJD1C, implicating DNA methylation\u2013mediated regulation. Multi-omics and tissue analyses identified VHL as the most consistent risk gene, supported by colocalization, TCGA HNSC transcriptomic validation (P &lt; 0.01), and DepMap functional data. GEN1 and POU5F1 expression in salivary gland tissue also associated with OCC risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This multilayer SMR study reveals causal links between DNA repair\u2013related genes and OCC, highlighting VHL as a key driver and suggesting targets for early detection and precision therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/18758592261455209","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:53:31Z","timestamp":1780923211000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative multi-omics analysis-based Mendelian randomization identifies association of DNA repair\u2013related genes with oral cancer"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3253-7489","authenticated-orcid":false,"given":"Jingbo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology, Shanghai Jiaotong University, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqing","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shanghai Jiaotong University, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilong","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shanghai Jiaotong University, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmin","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China"},{"name":"Department of Otorhinolaryngology, National Health Commission Key Laboratory of Otorhinolaryngology (Shandong University), Jinan 250012, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6958-5022","authenticated-orcid":false,"given":"Ying","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shanghai Jiaotong University, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shanghai Jiaotong University, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","unstructured":"Sankaranarayanan R Ramadas K Amarasinghe H et al. 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