{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T04:05:37Z","timestamp":1783915537225,"version":"3.55.0"},"reference-count":47,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the National Key R&D Program of China","award":["2022YFC2704201"],"award-info":[{"award-number":["2022YFC2704201"]}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515110333"],"award-info":[{"award-number":["2023A1515110333"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515013045"],"award-info":[{"award-number":["2024A1515013045"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M744070"],"award-info":[{"award-number":["2023M744070"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024T171074"],"award-info":[{"award-number":["2024T171074"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273365"],"award-info":[{"award-number":["82273365"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82403524"],"award-info":[{"award-number":["82403524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Medical Science and Technology Research Foundation","award":["A2024280"],"award-info":[{"award-number":["A2024280"]}]},{"name":"Science and Technology Plan of Guangdong Province","award":["2023A0505050102"],"award-info":[{"award-number":["2023A0505050102"]}]},{"name":"Guangzhou Science and Technology Program","award":["2024B03J1336"],"award-info":[{"award-number":["2024B03J1336"]}]},{"name":"Sun Yat-sen University Clinical Research Foundation of 5010 Project","award":["2017006"],"award-info":[{"award-number":["2017006"]}]},{"name":"Postdoctoral Fellowship Program of CPSF","award":["GZC20233282"],"award-info":[{"award-number":["GZC20233282"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Biomarkers"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>Early detection of ovarian cancer, particularly high-grade serous ovarian cancer (HGSOC), remains challenging due to the lack of reliable biomarkers. This study investigated the potential of tRNA-derived small RNAs (tsRNAs) as non-invasive diagnostic biomarkers using liquid biopsy. Using qRT-PCR, we analyzed the relative Ct values of selected tsRNAs in plasma samples from healthy controls and patients with early- and late-stage HGSOC. A logistic regression model constructed using the relative Ct value of the selected tsRNA demonstrated high sensitivity and specificity for distinguishing ovarian cancer patients from healthy controls, including those with early-stage disease. The model was validated in a multi-center cohort, and analysis confirmed the dysregulation of this tsRNA in tumor tissue compared to normal tissue. These findings suggest that this single plasma tsRNA may serve as a promising biomarker for early HGSOC detection, supporting its potential clinical utility pending further mechanistic studies.<\/jats:p>","DOI":"10.1177\/18758592261463300","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:50:44Z","timestamp":1783745444000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel diagnostic model for early-stage high-grade serous ovarian cancer based on serum tRNA-derived fragments"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0820-0765","authenticated-orcid":false,"given":"Xueyuan","family":"Zhao","sequence":"first","affiliation":[{"name":"Sun Yat-sen University"},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases, Guangzhou, Guangdong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Wen","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University"},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases, Guangzhou, Guangdong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jia","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University"},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases, Guangzhou, Guangdong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yuan","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University"},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases, Guangzhou, Guangdong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linna","family":"Chen","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University"},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases, Guangzhou, Guangdong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songlin","family":"Liu","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University"},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases, Guangzhou, Guangdong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolin","family":"Fan","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University"},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases, Guangzhou, Guangdong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongye","family":"Jiang","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University"},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases, Guangzhou, Guangdong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyun","family":"Pan","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University"},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases, Guangzhou, Guangdong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhong","family":"Yao","sequence":"additional","affiliation":[{"name":"Sun Yat-sen University"},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases, Guangzhou, Guangdong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-023-00617-9"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002580"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2018.07.003"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.10.032"},{"issue":"5","key":"e_1_3_7_7_2","first-page":"619","article-title":"New Therapies for Ovarian Cancer","volume":"17","author":"O'Malley DM","year":"2019","unstructured":"O'Malley DM. New Therapies for Ovarian Cancer. J Natl Compr Canc Netw 2019; 17(5.5): 619\u2013621, PMID: 31117037. https:\/\/doi.org\/10.6004\/jnccn.2019.5018","journal-title":"J Natl Compr Canc Netw"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-021-02149-x"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2024.126782"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-02193-1"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01739-5"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00955-6"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1706908114"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2021.06.023"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02101-z"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25179567"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2024.104504"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.31722"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2023.148097"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.11.058"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-021-00652-7"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1109\/TPAMI.2019.2901688"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.7632"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70012"},{"key":"e_1_3_7_25_2","article-title":"Immunotherapy for ovarian cancer: towards a tailored immunophenotype-based approach","volume":"4","author":"Ghisoni E","year":"2024","unstructured":"Ghisoni E, Morotti M, Sarivalasis A, et al. Immunotherapy for ovarian cancer: towards a tailored immunophenotype-based approach. Nat Rev Clin Oncol 2024; 4. https:\/\/doi.org\/10.1038\/s41571-024-00937-4, Epub ahead of print. PMID: 39232212.","journal-title":"Nat Rev Clin Oncol"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04510-8"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-02086-3"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-018-0063-0"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.224"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-06937-z"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2021.188503"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-016-0309-1"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2021.12.009"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-00306-0"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2020.01.012"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2020.104381"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2019.107458"},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231912041"},{"key":"e_1_3_7_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-020-00211-7"},{"key":"e_1_3_7_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.07.026"},{"key":"e_1_3_7_41_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-2797"},{"key":"e_1_3_7_42_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.80054"},{"key":"e_1_3_7_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01499-8"},{"key":"e_1_3_7_44_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01588-8"},{"key":"e_1_3_7_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2024.1346852"},{"key":"e_1_3_7_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2022.11.033"},{"key":"e_1_3_7_47_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14010024"},{"key":"e_1_3_7_48_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5594081"}],"container-title":["Cancer Biomarkers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/18758592261463300","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/18758592261463300","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/18758592261463300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T03:46:54Z","timestamp":1783914414000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/18758592261463300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":47,"alternative-id":["10.1177\/18758592261463300"],"URL":"https:\/\/doi.org\/10.1177\/18758592261463300","relation":{},"ISSN":["1574-0153","1875-8592"],"issn-type":[{"value":"1574-0153","type":"print"},{"value":"1875-8592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"article-number":"18758592261463300"}}