{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:03:58Z","timestamp":1790946238477,"version":"4.1.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100011096","name":"Jazz Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tremor is reported by people with Parkinson's disease (PwP) as being one of the most troublesome symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the PwP experience of tremor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An internet-based survey of PwP living with tremor was conducted in the US, from September 2023 to March 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Survey responses from 634 respondents (PwP\u2009=\u2009599; care partner\u2009=\u200935) were analyzed. Most (93%) PwP had tremor in their upper extremities and of these, 59% reported \u22652 tremor subtypes (rest\/postural\/kinetic). Overall, 24% reported little or no effect of medication and a further 25% reported that medication only somewhat improved their tremor. At least mild functional impairment due to tremor was reported by 65% of PwP and most indicated that \u22651 daily activity (83%), sensory experience (77%), or psychosocial function (92%) was impacted. Multinomial logistic regression analyses revealed that the odds [95%CI] of reporting severe functional impairment due to tremor (vs. slight) were increased by worse tremor in the dominant hand (4.9 [1.36, 17.72]); presence of OFF-time (4.7 [1.22, 18.30]), number of body parts affected (2.0 [1.45, 2.88]) and lack of medication effect (1.6 [0.30, 8.22]). The presence of all three tremor subtypes was associated with increased odds of being \u201c\n                      <jats:italic toggle=\"yes\">very dissatisfied<\/jats:italic>\n                      \u201d with quality of life (21.5 [2.51, 183.44]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results from this survey demonstrate that tremor in PD is often more than a rest tremor and frequently impacts function and activities of daily living. Medication response is inadequate in about half of cases, highlighting that effective treatment of tremor is an important unmet need.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1877718x251329328","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T03:54:55Z","timestamp":1742788495000},"page":"541-551","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Burden of tremor in Parkinson's disease: A survey study"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6369-1203","authenticated-orcid":false,"given":"Robert A","family":"Hauser","sequence":"first","affiliation":[{"name":"University of South Florida, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara Crowder","family":"Skarpaas","sequence":"additional","affiliation":[{"name":"Jazz Pharmaceuticals, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a","family":"Merriam","sequence":"additional","affiliation":[{"name":"Parkinson &amp; Movement Disorder Alliance, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6866-0538","authenticated-orcid":false,"given":"Jason","family":"Rivera","sequence":"additional","affiliation":[{"name":"Parkinson &amp; Movement Disorder Alliance, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valmira","family":"Hoxhaj","sequence":"additional","affiliation":[{"name":"Jazz Pharmaceuticals, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6574-0604","authenticated-orcid":false,"given":"Luigi M","family":"Barbato","sequence":"additional","affiliation":[{"name":"Jazz Pharmaceuticals, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Chadha-Patel","sequence":"additional","affiliation":[{"name":"ACP Clinical Communications Ltd, Hertfordshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Baladi","sequence":"additional","affiliation":[{"name":"Jazz Pharmaceuticals, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.131045"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540020018011"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.5334\/tohm.552"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-020-00894-7"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx376"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870131303"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13845"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.04.019"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00628"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-140446"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23135"},{"issue":"2","key":"e_1_3_5_14_2","article-title":"Chief complaints of patients with Parkinson's disease","volume":"52","author":"Wendell CM","year":"1999","unstructured":"Wendell CM, Hauser RA, Nagaria MH, et al. Chief complaints of patients with Parkinson's disease. Neurology 1999; 52(Supplement 2): A90\u2013A91.","journal-title":"Neurology"},{"key":"e_1_3_5_15_2","unstructured":"Chapman M. People with Parkinson\u2019s tremor asked to take part in survey https:\/\/parkinsonsnewstoday.com\/news\/parkinsons-tremor-patients-needed-survey-symptom-burden\/. (2024)."},{"key":"e_1_3_5_16_2","unstructured":"Ciccone I. PMD Alliance Survey Aims to Understand Burden of Tremor in Parkinson Disease https:\/\/www.neurologylive.com\/view\/pmd-alliance-survey-aims-understand-burden-tremor-pd. 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