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However, recent findings indicate that widespread neuronal CI deficiency in the brain is only present in a subpopulation of 20\u201330% of cases. This stratification may be relevant for selecting participants for clinical trials, emphasizing the need for clinically applicable biomarkers. We previously reported CI deficiency in skeletal muscle biopsies of a subpopulation of persons with PD (PwPs), suggesting potential for mitochondrial stratification using extra-neural tissues. Platelets are another tissue previously reported to exhibit mitochondrial respiratory defects in PD. However, studies have generally involved small sample sizes and reported variable results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether platelets exhibit impaired mitochondrial respiratory chain complex activity in PwPs, or in a subpopulation of PwPs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using spectrophotometric activity assays, we assessed CI and complex IV (CIV) activities in platelet samples from 61 PwPs and 31 neurologically healthy controls from a well-characterized prospective cohort. The correlation between activities measured in platelets and skeletal muscle was also explored in 51 of the same individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Platelet CI and CIV activities showed no difference between PwPs and controls at the group level, nor evidence of a subgroup with deficiency of either complex. There was no correlation between complex activities in platelet samples and skeletal muscle biopsies from the same individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on these results, we propose that platelet CI or CIV activities are not sensitive markers of mitochondrial dysfunction in PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1877718x251365253","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T07:07:01Z","timestamp":1755155221000},"page":"1218-1228","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Platelet mitochondrial complex I and IV activities are not reliable stratification biomarkers in Parkinson's disease"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8507-8127","authenticated-orcid":false,"given":"Simon Ulvenes","family":"Kverneng","sequence":"first","affiliation":[{"name":"Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Bergen, Norway"},{"name":"K.G. Jebsen Center for Translational Research in Parkinson's disease, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4652-5203","authenticated-orcid":false,"given":"Sepideh","family":"Mostafavi","sequence":"additional","affiliation":[{"name":"Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Bergen, Norway"},{"name":"K.G. Jebsen Center for Translational Research in Parkinson's disease, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5872-0495","authenticated-orcid":false,"given":"Yana","family":"Mikhaleva","sequence":"additional","affiliation":[{"name":"Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Bergen, Norway"},{"name":"K.G. Jebsen Center for Translational Research in Parkinson's disease, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0298-566X","authenticated-orcid":false,"given":"Gard Aasmund Skulstad","family":"Johanson","sequence":"additional","affiliation":[{"name":"Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Bergen, Norway"},{"name":"K.G. 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Jebsen Center for Translational Research in Parkinson's disease, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6814-9460","authenticated-orcid":false,"given":"Katarina","family":"Lundervold","sequence":"additional","affiliation":[{"name":"Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Bergen, Norway"},{"name":"K.G. 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