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It seems to be a risk factor for conversion to dementia (PDD) in this population. Amyloid-\u03b2 deposition also predicts progression to PDD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to investigate whether PD patients with apathy showed higher amyloid burden than those without, as well as how these features may influence the rate of progression to dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted an observational cross-sectional and longitudinal study. Forty-eight PD patients were recruited, including 20 with apathy and 28 without it according to the Starkstein Apathy Scale. They underwent clinical and cognitive evaluations and [\n                      <jats:sup>18<\/jats:sup>\n                      F]-Flutemetamol PET. The neuropsychological assessment was repeated after 3 years. The predictive value of apathy and amyloid burden for conversion was assessed via logistic regression. Longitudinal trajectories across neuropsychological tests were modeled with linear mixed-effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with apathy showed worse performance on several cognitive domains. Using disease duration and global cognition Z-score as covariates, amyloid burden was higher in apathetic vs. non-apathetic patients, mainly in the frontal and temporal cortices. Non-apathetic patients did not have regions with higher amyloid burden in comparison with apathetic patients. After 3 years\u2019 follow-up, the conversion rate to worse cognitive state was significantly higher in apathetic (47.4%) vs. non-apathetic (12.0%) patients (p\u2009&lt;\u20090.05). Logistic regression showed that amyloid burden, but not apathy, predicted 3-year cognitive conversion (\u03c7\u00b2\u2009=\u20099.95, p\u2009&lt;\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Apathetic patients exhibit greater amyloid burden and higher cognitive deterioration over time than their non-apathetic counterparts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1877718x251370969","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T18:10:19Z","timestamp":1758132619000},"page":"1452-1464","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Apathy linked to higher amyloid burden and cognitive deterioration in Parkinson's disease"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7411-8106","authenticated-orcid":false,"given":"Carmen","family":"Gasca-Salas","sequence":"first","affiliation":[{"name":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria HM Hospitales, Madrid, Spain"},{"name":"Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain"},{"name":"University CEU-San Pablo, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3469-6395","authenticated-orcid":false,"given":"Roberto","family":"Fern\u00e1ndez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria HM Hospitales, Madrid, Spain"},{"name":"C.E.P. San Carlos, Hospital Universitario El Escorial, San Lorenzo de El Escorial, Madrid, Spain"},{"name":"PhD Program in Health Sciences, University of Alcal\u00e1 de Henares, Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2903-199X","authenticated-orcid":false,"given":"Rafael","family":"Rodr\u00edguez-Rojas","sequence":"additional","affiliation":[{"name":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria HM Hospitales, Madrid, Spain"},{"name":"Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Fern\u00e1ndez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"HM CINAC (Centro Integral de Neurociencias Abarca 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