{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T06:28:49Z","timestamp":1786343329639,"version":"build-2736575974"},"reference-count":38,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100009673","name":"Gun och Bertil Stohnes Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009673","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018713","name":"Center for Innovative Medicine","doi-asserted-by":"publisher","award":["FoUI-973826"],"award-info":[{"award-number":["FoUI-973826"]}],"id":[{"id":"10.13039\/501100018713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018713","name":"Center for Innovative Medicine","doi-asserted-by":"publisher","award":["FoUI-975387"],"award-info":[{"award-number":["FoUI-975387"]}],"id":[{"id":"10.13039\/501100018713","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Regional Agreement on Medical Training and Clinical Research (ALF) between Karolinska Institutet and Region Stockholm","award":["RS2021-0855"],"award-info":[{"award-number":["RS2021-0855"]}]},{"DOI":"10.13039\/100009389","name":"Stiftelsen Promobilia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009389","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Augusta and Petrus Hedlunds Stiftelse"},{"name":"Aina B\u00f6rjesons Stiftelse"},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2016-01965"],"award-info":[{"award-number":["2016-01965"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2022-00636"],"award-info":[{"award-number":["2022-00636"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004875","name":"Norrbacka-Eugeniastiftelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004875","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008443","name":"ParkinsonF\u00f6rbundet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008443","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Speech and voice symptoms are common in Parkinson's disease, yet predictors of response to behavioral speech interventions are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify predictors of responsiveness to a speech and communication group-intervention (HiCommunication) and contextualize findings against active controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This secondary analysis of a randomized controlled trial included intervention completers. Responders were defined for voice intensity (increase \u22652 decibels) and voice quality (Acoustic Voice Quality Index decrease \u22650.54). Nineteen baseline clinical, motor, cognitive, perceptual, and acoustic variables were entered into Random Forest classifiers. Primary models excluded the baseline value of the target domain; baseline-including variants were sensitivity analyses. Performance was evaluated using Cohen's kappa, precision, recall, and specificity; key predictors were examined using partial dependence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In HiCommunication (n\u2009=\u200935), the primary voice intensity model showed moderate agreement (kappa\u2009=\u20090.57; precision\u2009=\u20090.79; recall\u2009=\u20090.90; specificity\u2009=\u20090.64). Higher baseline perceptual ratings of reduced loudness and overall speech deviation, as well as higher Acoustic Voice Quality Index values, were associated with a higher predicted probability of improvement in voice intensity, whereas higher levodopa equivalent daily dose was associated with a lower response probability; postural instability\/gait difficulty or tremor-dominant motor phenotypes showed higher response probability than the indeterminate phenotype. Voice quality models were below chance without baseline Acoustic Voice Quality Index but reached kappa 0.38 when included. Active control models showed low performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clinically accessible baseline measures predicted improvement in voice intensity following HiCommunication with moderate accuracy. Perceptual ratings may support expectation-setting and individualized planning of group-based speech intervention in Parkinson's disease, but findings require replication.<\/jats:p>\n                    <jats:p>ClinicalTrials.gov ID: NCT03213873, doi: 10.1177\/1545968321999053<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Plain Language Title<\/jats:title>\n                    <jats:p>Who benefits most from group-based speech and communication therapy in Parkinson's disease? This study explored whether simple clinical and speech measures collected before treatment can help predict which people with Parkinson's disease are most likely to improve their voice loudness after participating in an intensive group-based speech and communication program.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1877718x261453191","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T12:27:53Z","timestamp":1779712073000},"page":"965-979","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Baseline predictors of response to a group-based speech and communication intervention in Parkinson's disease: A secondary analysis of a randomized controlled trial"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6317-898X","authenticated-orcid":false,"given":"Hanna","family":"Steurer","sequence":"first","affiliation":[{"name":"Karolinska Institutet"},{"name":"Stockholms Sjukhem"},{"name":"Uppsala University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellika","family":"Schalling","sequence":"additional","affiliation":[{"name":"Karolinska Institutet"},{"name":"Uppsala University"},{"name":"Uppsala University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Franz\u00e9n","sequence":"additional","affiliation":[{"name":"Stockholms Sjukhem"},{"name":"Karolinska Institutet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joakim K\u00f6rner","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Karolinska Institutet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5891-445X","authenticated-orcid":false,"given":"Franziska","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Karolinska Institutet"},{"name":"Karolinska University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afj053"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1044\/2017_AJSLP-16-0087"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1044\/2023_AJSLP-23-00274"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcae235"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269215520976267"},{"key":"e_1_3_3_7_2","first-page":"3366870","article-title":"Lee Silverman voice treatment to improve speech in Parkinson's disease: a systemic review and meta-analysis","volume":"2021","author":"Pu T","year":"2021","unstructured":"Pu T, Huang M, Kong X, et al. Lee Silverman voice treatment to improve speech in Parkinson's disease: a systemic review and meta-analysis. Parkinsons Dis 2021; 2021: 3366870. 2022\/01\/25.","journal-title":"Parkinsons Dis"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14399"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27460"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2008\/019)"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2150"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2025.06.015"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1044\/2024_AJSLP-24-00222"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-017-1676-0"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.22360"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318203e7d0"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25816"},{"key":"e_1_3_3_18_2","first-page":"850596","article-title":"Effect of deep brain stimulation on speech performance in Parkinson's disease","volume":"2012","author":"Skodda S","year":"2012","unstructured":"Skodda S. Effect of deep brain stimulation on speech performance in Parkinson's disease. Parkinsons Dis 2012; 2012: 850596\u2013850510.","journal-title":"Parkinsons Dis"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29282"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-025-08420-3"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.14194"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-019-1520-2"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968314567150"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-021-00269-5"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-12-111"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360.0602.85"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-012-2649-0"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010933404324"},{"key":"e_1_3_3_29_2","first-page":"18","article-title":"Classification and regression by randomForest","volume":"2","author":"Liaw A","year":"2002","unstructured":"Liaw A, Wiener M. Classification and regression by randomForest. R News 2002; 2: 18\u201322.","journal-title":"R News"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-018-2264-5"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22340"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24893"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","unstructured":"Stebbins GT Goetz CG Burn DJ et al. How to identify tremor dominant and postural instability\/gait difficulty groups with the movement disorder society unified Parkinson's disease rating scale: comparison with the unified Parkinson's disease rating scale. 2013; 28: 668\u2013670. DOI: 10.1002\/mds.25383","DOI":"10.1002\/mds.25383"},{"key":"e_1_3_3_36_2","volume-title":"Dysartri - bed\u00f6mning och intervention : vid f\u00f6rv\u00e4rvade neurologiska talst\u00f6rningar hos vuxna","author":"Hartelius L","year":"2015","unstructured":"Hartelius L. Dysartri - bed\u00f6mning och intervention : vid f\u00f6rv\u00e4rvade neurologiska talst\u00f6rningar hos vuxna. Lund: Studentlitteratur, 2015."},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9450.2008.00653.x"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcomdis.2009.12.004"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012878"}],"container-title":["Journal of Parkinson\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1877718X261453191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1877718X261453191","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1877718X261453191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T05:45:26Z","timestamp":1786340726000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1877718X261453191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1177\/1877718X261453191"],"URL":"https:\/\/doi.org\/10.1177\/1877718x261453191","relation":{},"ISSN":["1877-7171","1877-718X"],"issn-type":[{"value":"1877-7171","type":"print"},{"value":"1877-718X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]}}}